For New Year’s Day, I’m republishing the top 10 articles I wrote in 2013. Well, actually top 9, plus 1 from 2012 that just keeps going.
#8. This article was published on 26 September 2013, and has had nearly 6000 views. This was one of the most difficult articles I’ve ever written. Anyone who thinks that the immune system is so simple that they can make broad proclamations about what does what to the immune system simply lacks any real education in immunology. And only vaccinations can really boost the immune system.
One of the most ubiquitous pseudoscientific claims that I keep hearing from the junk medicine crowd is that this supplement or that food “boosts” the immune system. These type of claims ignore one basic physiological fact: the immune system is a complex interconnected network of organs, cells, and molecules that prevents invasion of the body by hundreds of thousands, if not millions of pathogens every day. And no matter how much individuals try to trivialize how complicated the immune system is by claiming that downing a few tablets of echinacea will boost the immune system to prevent colds (it doesn’t), it doesn’t make it science.
And it isn’t that simple.
Using the Graham Coghill’s Science Red Flags, which are indicators of either bad science or unscientific nonsense (and which I’ve used with respect to GMOs), let’s do a quick review of a few outlandish claims of the junk medicine horde. I just cherry picked a few, because their pseudoscience is not the focus of this article. I don’t have that much time to find all the “immune system” rubbish on the internet!
The pseudoscience of boosting the immune system
|The Red Flag||What “immune booster” proponents say|
|The ‘scientifically proven’ subterfuge.||Apparently, without actually showing us any evidence, individuals like to state that this food or that supplement is “scientifically proven” to boost your immune system. Setting aside the semantic point that science doesn’t “prove” anything, it provides evidence in support or refutation of a hypothesis, and the body of evidence is used to support a scientific principle, where is the body of evidence?|
|Empty edicts – absence of empirical evidence||Yes, you’ll read this all the time. The claim of “it is widely known that XYZ boosts your immune system.” Widely know? By whom? Unless it’s widely known in the narrow mind of the Health Ranger, and his anti-scientific and junk medicine pushing claims about what boosts the immune system.|
|Anecdotes, testimonials and urban legends||Anecdotes are de facto evidence of the pseudoscience pushing crowd. The problem is that anecdotes don’t equal data, and more anecdotes doesn’t equal better data. You hear this all the time from your friends, TV commercials, or nonsense posted on your Facebook wall. You know it, when you see it, “I took XYZ, and I never got the flu.” Or worse yet, I’ve heard from my mother’s friend’s cousin’s hairdresser that XYZ prevents colds. Let me remind everyone anecdotes do not equal evidence, and more anecdotes do not make more evidence.|
|Stressing status and appealing to authority||One of their common ploys of the junk medicine crowd is to employ the Argument from False or Misleading Authority, which is when someone provides an argument from an authority, but on a topic outside of the particular authority’s expertise or on a topic on which the authority is not disinterested. Furthermore, arguments from authority are judged not on the fact that individual is an authority, but on the quality and quantity of evidence supporting the authority’s conclusions. Here, someone tries to convince us of the immune boosting properties of certain foods. One of the coauthors is an RD (registered dietician), which is not a scientific degree. Again, there is no evidence that any of the foods listed does anything for the immune system.
|Devious deception in displaying data: Cherry picking||Junk Medicine pushers love Cherry Picking. They will focus on one or two legitimate studies (or worse yet, only a part of the a study), while ignoring the body of evidence. Science does not function by inventing a conclusion and finding only data (or research) that supports the conclusion; in fact, good science examines the peer-reviewed data and find where it leads.|
|Duplicity and distraction||This is the False Dichotomy logical fallacy, which states that there are only two possible, and usually opposite, positions from which to choose. Either take this supplement, eat this food, or drink this juice, or you will die a horrific death because your immune system will just quit working. Uh no. That’s not what we know about the immune system.|
|Appeals to ancient wisdom – trusting traditional trickery||In the world of foods, somehow there’s a belief that our ancestors ate better and healthier. And some go back to 10-20,000 years ago to try to convince everyone that the “Paleolithic diet” is the right one. Or that somehow our ancestors ate better, organic foods. Or that farmers knew better how to farm in the 13th century. In fact, food is better today because we have better transportation systems which means there’s less spoilage and generally healthier. Humans today not only live longer today, we live more productive active lives. Although there are lots of reasons for this (vaccinations, sanitation, medicines), one of the reasons is more and better food. Our ancestors had pests, wars, plagues (which killed laborers), and many other issues that made food worse. Children died younger and from disease we just don’t, and they were supposedly eating that wonderful immune boosting food. I guess not.|
|Technobabble and tenuous terminology: the use of pseudo scientific language||In this tactic, people use invented terms that sound “sciencey” or co-opt real science terms and apply them incorrectly, and it’s one of the fundamental tenets of pseudoscience. Despite all of these outlandish claims about various things “boosting the immune system,” no one provides a plausible pathway for it. I wrote an article about people misunderstanding of a study that used banana extract placed inside the abdomen of rodents. Foreign bodies in the abdominal cavity will nearly always induce an immune response, the bananas are irrelevant. And then junk medicine gang went crazy happy over this study, stating that bananas have a small protein called TNF that has some robust effects (many of them quite negative and deadly) on the immune system. Well bananas don’t have TNF, and even if it did, you couldn’t absorb it after eating a banana, and even if you could absorb it, you couldn’t eat enough bananas to have a physiological effect.|
|Conflating correlation with causation: rooster syndrome||The infamous Post hoc ergo propter hoc logical fallacy, which is essentially a belief that because a second event follows the first, the first event must be the cause of the second. So eat your broccoli kids, because 10 people who ate their broccoli didn’t get cancer.|
|Banishing boundaries and pushing panaceas – applying models where they don’t belong||Those who use this tactic take a model that works under certain conditions and try to apply it more widely to circumstances beyond its scope, where it does not work. My aforementioned banana article is a perfect example of this boundary issue. The authors of the original article induced the production of TNF (a natural response of the body to foreign substances) by essentially grinding up bananas and placing it in the the abdominal cavity of rodents. Then they measured TNF (tumor necrosis factor) levels. But the woo-pushing gang, went crazy over the study. Dismissing all of the data and methodology of the article, they claimed BANANAS BOOST THE IMMUNE SYSTEM TO CURE CANCER. No it doesn’t. And TNF is a poorly name protein in the immune system, since it doesn’t kill cancer cells. And too much of it can be quite dangerous to your health. (By the way, this banana cancer meme is completely zombified, I get hundreds of hits to the article every day).|
|Appeal to nature – the authenticity axiom||“Boosting the immune system” believers push the Appeal to Nature, which is the belief or suggestion that “natural” is always better than “unnatural”. It assumes that “nature” is good, and “unnatural” is not. Yoni Freedhof, an MD and Professor of Family Medicine, recently wrote that, believing that nature is good, and chemicals are bad, “is arrogant because it suggests that the entirety of the natural world has been created purely as a service to humankind – that somehow the earth and everything on it grows simply for our pleasure or our consumption.” There is nothing in nature that is necessarily and inherently better than something invented by mankind, but the believers want to believe that everything natural must be better for humans. Because you know that evolution happened just to benefit Homo sapiens.|
The science of the immune system
Now comes the science part of the article. I, and others, always complain that the junk science world massively oversimplifies the mechanisms of the immune system. They make it sound like there is just one pathetic, weak, hardly functional little organ called the “immune system” that apparently can be knocked out if you drink the wrong water.
But in fact, the immune system is a huge, complex, interrelated bunch of biomolecules, cells, tissues and organs, usually all working in harmony. And it’s pretty resilient. If the immune system was such a weakling, we would all be dead from pathogens before we made it to our 5th year of life. And there is a reason, why we make it past your 5th year of life, but I’ll get to that.
So, if someone says “this boosts your immune system,” your first question must be “which of the thousands of different parts? Your second question should probably be “do you have a peer-reviewed article that supports that wild claim?”
OK, here we go. Basic immunology:
Parts of the Immune System
Innate–This is the immune system’s ability to prevent or detect foreign material, then eliminate it without a specific physiological response of the body. It is the body’s quick and initial response to disease causing organisms (pathogens) which invade our body. The innate response either directly prevents an infection or slows it sufficiently for the slower but more effective and selective adaptive Immune system to activate. But it isn’t a simple system, the innate immune system is extremely complex, consisting of:
- Anatomical barriers–These consist of physical barriers. The skin itself is impermeable to pathogens providing defenses like a solid wall. Our nasal passage is lined with mucous that is constantly moved into the stomach catching pathogens and killing them. Our eyes are covered in caustic tears and our mouths in saliva which contains a variety of enzymes. all these ensure that the vast majority of pathogens are killed before they can even enter an area where they can cause harm.
- Inflammation–This response include the symptoms we associate with inflammation, fever, swelling, increased blood flow, and other activities, is due to the localized response of the body to the presence of a foreign body or pathogen. It’s main purpose is to provide a physical barrier to control the spread of infection and to heal damaged tissue in the region. Damaged cells release an array of chemical factors which cause pain and blood vessels to become more permeable. This response then attracts phagocytes, cells which recognize and consume foreign or dead tissue. Inflammation is normally a healthy response to injury or pathogen invasion, but in some autoimmune diseases, such as rheumatoid arthritis, it can be painful and debilitating.
- Complement System–This system is group of biochemicals, produced by the liver, that helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the immune system that is not adaptable and does not change over the course of an individual’s lifetime. However, it can be recruited and brought into action by the adaptive immune system.
- Cells–Mostly white blood cells (WBC) are involved in the innate immune system:
- Mast Cells - A group of cells that mediate the inflammatory response. Although they are often associated with allergies, they are a critical part of the immune response.
- Phagocytes - Large cells that move like amoeba. They “eat” other cells by surrounding them with their plasma membranes producing “bubbles” in which they can release enzymes safely without damaging other cells. They also have a “clean-up” role to remove the body’s dead and dying cells.
- Macrophages - Large phagocytic cells that efficiently consume multiple pathogens. Heavily motile and actively cross from the blood stream into tissue to hunt down pathogens. They kill by manufacturing and releasing free-radical oxygen in a local area.
- Neutrophils/Eosinophils/Basophils - A group of similar cells that are the “first responders” to migrate to an inflammation site. They appear at the site of a wound within a few minutes of trauma.
- Natural Killer Cells - These cells recognize the body’s own cells that are infected by viruses or are cancerous. They then induce controlled cell death to halt the spread of the infected or cancerous cells. Recent research shows that Natural Killer Cells also play a role in the adaptive immune response.
- Dendritic Cells and Gamma/Delta T Cells - These are the bridge between the innate and adaptive systems and their main role is antigen presentation. They harvest antigenic proteins from damaged pathogens and present them to T-Cells, which allows them to find and attack the pathogens.
Adaptive–The dendritic cells, from the innate immune system, activate the body’s adaptive (or acquired) immune system. The adaptive immune system is composed of highly specialized, systemic cells and processes that eliminate or prevent pathogen growth. In acquired immunity, pathogen-specific receptors are “acquired” during the lifetime of the organism (whereas in innate immunity pathogen-specific receptors are already encoded in the germline). The acquired response is said to be “adaptive” because it prepares the body’s immune system for future pathogenic challenges. In some cases, the acquired immune response can be maladaptive when it results in autoimmunity. Antibodies, produced by B-lymphocyte cells, are the main weapon of the body’s immune system to battle pathogens. It is a larger response than innate immunity and once sensitized to an antigen, the adaptive immune system often fights of diseases even before we can exhibit symptoms of disease. Immunizations introduce the pathogen’s antigen to the adaptive immune system so that it can form those pathogen-specific receptors and, thereby, are able to quickly and efficiently respond to an attack by a pathogen.
- Cells involved –There are three types of cells involved with the adaptive immune response:
T – Lymphocytes (also known as T-cell) - The main role of the cell is to recognise cells infected by viruses and trigger the apoptotic pathway that destroys the cell and its viral contamination. Since viruses only replicate inside cells by hijacking the cell’s manufacturing process, this apoptosis kills the virus (and the host cell) and phagocytes swoop in to consume the destroyed cell debris and digest the contents. The antigen of the viral cell is recognised by surface antibodies on the T-Lymphocyte, which activate it. There are also helper T-Cells whose role is control and organisation of the apoptosis response to the infected cells.
B – Lymphocytes - The main role of these cells is to produce humoral (free floating) antibodies that recognise pathogens and mark them for destruction by other cells. This process occurs by activating the complement system and by causing the pathogen to become “sticky” but only with other pathogens. This causes them to clump together and make them easier to kill by T-cells.
Memory Cells - After an infection has passed (and most of the T-cells and B-cells have died), a few do remain in circulation to remember the antigens of the pathogens who attacked. In future infections these are rapidly activated to produce a humoral response which quickly destroys any new infections even before they produce any symptoms. There are two types of these cells: Memory B cells, which, produce the antibodies that recognize the pathogens, and Memory T cells, which remember the viral antigens that infect cells.
Note: in Infants, there is a version of the immune system called passive immunity. Certain classes of antibodies can cross the placental barrier and can be absorbed through milk particularly the colostrum (first milk). These give the new born baby the same range of protection as the mother. However, the baby’s immune system does not develop its own adaptive immune response from these antibodies, and eventually must be presented with one of the millions of antigens it inhales every day to form its own adaptive immune system.
The innate and adaptive immune systems are pretty freaking awesome, but it’s not perfect. Pathogens have evolved over a billion years or so in response to other organisms’ immune systems, so they have developed all kinds of tricks to avoid being massacred by the human immune system. The influenza virus is one of the experts of quickly evolving to change itself almost annually to avoid the immune system. HPV (human papillomavirus) avoids the immune system by actually integrating itself into the human DNA.
So, we have an effective and highly aggressive immune system already. So obviously there are ways to boost this system. Right?
The scientific evidence for boosting the immune system
So, there’s the awesome complexity of the immune system. There is a multitude of immune system related cells, each produced in different areas of the body, each with a different responsibility. Some of these cells produces literally millions of different antibodies, each with a separate responsibility to attack diseases.
And precisely what substance could make that highly complex system work better? In general, the immune system is an on/off type of network. It’s either working perfectly well, or it isn’t, and we know the precise conditions that might cause the immune system to start working less perfectly.
According to The US National Institute of Allergy and Infectious Diseases; the Harvard Medical School; The European Federation of Immunological Societies; the University of Rochester Medical Centre; and Science-Based Medicine, we can conclude that:
- There are some chronic conditions, such as stress and malnutrition (I’m not talking about not enough oranges, but large, long-term calorie deficits), that can reduce the performance of your immune system.
- There are a few chronic diseases that can have an impact on the quality of the immune response, diabetes being one of the more prevalent, but there are many others.
- Some people are born with impaired immune systems. Some may acquire an immune deficiency as a result of certain diseases (HIV/AIDS being the most famous). Even some medical treatments, like chemotherapy or immunosuppresive therapies, can weaken or even destroy the immune system. An infection does not weaken the immune system; in fact, the sick feeling you have during a cold or other disease, can be a part of the immune response.
- Almost everyone has a perfect and highly effective immune systems–there is no way to make it better. OK, there might be one way, but it will take some thought to figure it out.
- In fact, there are reasons why we shouldn’t have a too powerful immune systems. For example, overactive immune systems are responsible for allergic conditions such as asthma and eczema. And there’s a type of runaway immune response known as a ‘cytokine storm‘ which is responsible for causing deaths in severe flu pandemics.
- The immune system can become misdirected and start attacking the cells of the host body. This immune system error can cause autoimmune diseases such as arthritis and Type 1 diabetes.
- There is little evidence that a normally functioning immune system can be ‘boosted’.
- ‘Boosting’ the immune system is probably not a good idea. Allergic reactions give us an indication of what happens when our immune systems are overactive.
There is a way to boost the immune system
So what we need is a way of beating diseases at their own game. A way of acquiring immunity to diseases without the disease itself. Let me think of a way, it’ll come to me.
That way is vaccination. Despite the complexity of the innate and adaptive immune systems, vaccinations are among the simplest medical procedures ever: we take known antigens and inject them into the body. The body’s adaptive immunity system recognizes these antigenic particles of the pathogen, and produce an immune response as if there were a real threat. Then the memory cells stick around to attack subsequent infections. Every infection your immune system stops actually increases the quality and speed of your immune response.
As long as we have been vaccinated, the adaptive immune system can respond quickly to a pathogen, prior to its having a long-lasting deleterious effect on the body or becoming infectious and spreading to others. No one makes the claim that vaccines are 100% effective, but as long as the vast majority of individuals are immune to a disease, it has a lower chance of spreading.
No we can’t boost the immune system with a handful of supplements or eating organic foods. The one way we make the immune system work better is through the scientific trick of vaccination, which maneuvers our bodies into thinking that it has fought of a disease when in reality it has not. Then it is ready to fight the disease when it shows up.
So there you go. You can’t strengthen your immune system with a bunch of supplements. But you can make it more powerful, better prepared to save you and your children’s lives with vaccinations. And science supports that statement.
If you need to search for scientific information and evidence about vaccines try the Science-based Vaccine Search Engine.
- Arina A, Murillo O, Dubrot J, Azpilikueta A, Alfaro C, Pérez-Gracia JL, Bendandi M, Palencia B, Hervás-Stubbs S, Melero I. Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer. Expert Opin Biol Ther. 2007 May;7(5):599-615. Review. PubMed PMID: 17477799.
- Clark IA. The advent of the cytokine storm. Immunol Cell Biol. 2007 Jun;85(4):271-3. PubMed PMID: 17551531.
- Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clin Exp Immunol. 2007 Feb;147(2):227-35. Review. PubMed PMID: 17223962; PubMed Central PMCID: PMC1810472.
- Janeway CA Jr, Travers P, Walport M, et al. Immunobiology: The Immune System in Health and Disease. 5th edition. New York: Garland Science; 2001. The complement system and innate immunity.
- Lohman RJ, Cotterell AJ, Barry GD, Liu L, Suen JY, Vesey DA, Fairlie DP. An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats. FASEB J. 2012 Jul;26(7):2877-87. doi: 10.1096/fj.11-201004. Epub 2012 Mar 30. PubMed PMID: 22467762.
Note: I have, without any conscience, liberally stolen the idea for this article, and some of the supporting information from fellow blogger and Australian Graham Coghill of the most excellent blog, Science or Not.