Andrew Wakefield sues BMJ for claiming MMR study was fraudulent | Society | guardian.co.uk.
Poor Andy. He writes a fraudulent article in The Lancet, which the prestigious journal eventually has to withdraw and his co-authors disown the same article. Brian Deer, a journalist for the Sunday Times of London, uncovers the fraud and publishes it in the British Medical Journal. Andy tries to sue Deer in UK courts, but essentially loses and has to pay all court costs and legal fees. Eventually, Andy is stripped of his medical license in the UK.
So, I guess the only choice of a fraud is to sue those who told the truth. Yes, this would be an ironic, even funny story, except for the deaths of children who should have been vaccinated against preventable diseases but weren’t because the parents heard about Andrew Wakefield’s fraudulent story.
Update from Missouri | NCSE.
The chief sponsor of this bill says the “jury is still out on evolution.” Uh, what jury is that? The one in Kitzmiller v. Dover, where a Federal Judge ruled that Intelligent Design is not science? Or the scientific community that say’s evolution is basically a fact? Or that intelligent design was “designed” to circumvent the Establishment Clause of the First Amendment to the US Constitution.
In case anyone forgot, that clause states:
Congress shall make no law respecting an establishment of religion.
So, Intelligent Design is a religious doctrine. The State of Missouri (well, at least some do) want to have that religious doctrine taught in public schools (run and funded by the State of Missouri). Sounds like they might have a legal challenge ahead.
This is my continuing multi-part discussion about how pseudoscience uses logical fallacies, strawman arguments, and other rhetoric to make its case, rather than real science. Just click on the links to read Part 1, Part 2, and Part 3.
The other day I engaged in a discussion with a well-meaning pharmacist who claimed that vitamin C could treat colds and prevent other diseases like “cancer” (I always get annoyed by people who lump all cancers together, when there are over 200 different cancers, all of which have different histologies, genetics, and causes). Of course, there are a number of well-controlled clinical trials that show that vitamin C has no effect on the common cold and has no effect on cancers so far studied (see this, this, this and this).
During our discussion, she said “science should be neutral,” with the implication that I wasn’t neutral. I happen to agree, science should be neutral and it should balanced. But science should be based upon the scientific method not rhetoric and not using science-y words, at which the writers of Star Trek were well-versed.
So, when I say that I am (or any evidence-based real scientist), “scientifically neutral”, that means I’m willing to weigh the evidence and publications on real scientific issues. I am not a geologist nor a paleontologist, but I was studying biochemistry when the earliest theories on what caused the Cretaceous-Tertiary extinction event 65.5 million years ago, where all the dinosaurs (well, not all, since technically modern birds are surviving dinosaurs from a cladistic point of view) and some 75% of all extant genera died out or were killed. In 1980, Luis Alvarez, a brilliant theoretical physicist whose career was extraordinary, along with his son, Walter Alvarez (a geologist), and Frank Asaro, published an article that describe a sedimentary layer across the world that included a rare element, iridium, usually found in extraterrestrial objects like meteors and comets. The layer fell right at the geological boundary layer that defines the extinction event, so they proposed that the dinosaurs were wiped out by a huge comet or asteroid.
Today, this accepted as a scientific theory with tons of confirming evidence (although some scientists aren’t fully convinced, though they still propose some natural event). But at the time, it was ridiculed, and scientific meetings were quite energetic in discussions. The point is that the impact theory displaced the prevailing scientific theory of the extinction event (well, there were several). One theory replaced another not by rhetoric or appeals to antiquity (that one theory was around forever) or anything else. In fact, one scientific hypothesis was replaced by another and eventually developed into a solid theory.
We should be neutral in science, reviewing the evidence, then coming to conclusions. The Alvarez father-son team provided that, and eventually there was overwhelming evidence with the finding and dating of the Chicxulub impact crater in the Yucatan Peninsula of Mexico.
Using scientific neutrality, vitamin C doesn’t work, not because I have an opinion, but because there is no science supporting its efficacy. There are some articles that support its use in preventing or treating colds, or megadoses for curing cancer, but those articles are in low-impact (meaning obscure) journals or with poorly designed, or non-blinded trials. My friendly neighborhood pharmacist was stating that I should be neutral between real science and well, nothing at all. That’s not balance, that’s a close-mindedness to science and the scientific method. That’s using opinion as the balance to scientific knowledge. The only thing that should balance scientific knowledge is more scientific knowledge.
Don’t fall for the trap that you should be “open-minded” or neutral to anti-science or pseudoscience. Open-mindedness and neutrality are expectations that you will balance real scientific evidence, not treat the rhetoric as if it has equal weight to scientific method.
NIH Director Calls for Rigorous Evaluation of Integrative Medicine to Provide Evidence of Efficacy – The ASCO Post.
Francis Collins, Director of the National Institutes of Health, wants to continue finding complementary and alternative medicine (CAM) modalities in cancer because they are popular? So, we ignore the fact that most CAM has no basis in science (basic principles biology, chemistry, physiology and physics are misunderstood or even dismissed)? We ignore the fact that there is no CAM therapy has ever been shown to work?
Collins, you’re much smarter than me, better educated, and more successful in medicine. So, are you deluded? Well, I actually have an answer to that (your fundamentalist Christian beliefs), but I’ll keep it to myself. Oh, I guess I didn’t.
A year without polio in India > Media room > Global Polio Eradication Initiative.
In two years, India went from the country with the most cases of polio to one with zero cases. They didn’t do this with magic water or pseudoscience, but good old fashioned vaccines.
A second antievolution bill in Missouri | NCSE.
Right after I pushed the “publish” button, I saw a second news article about Missouri. Apparently, there’s nothing really important going on in Missouri, so they decided to write two bills to add religious teaching in schools of Missouri.
This is sad, because Missouri is one of the top states in the USA for science education.
“Intelligent design” bill in Missouri | NCSE.
Not that anyone needs reminding, but just in case, Intelligent design is not scientific, it is not a scientific theory, and it is religion. In Kitzmiller v Dover Area School District, the US District Court held that:
Teaching intelligent design in public school biology classes violates the Establishment Clause of the First Amendment to the Constitution of the United States (and Article I, Section 3 of the Pennsylvania State Constitution) because intelligent design is not science and “cannot uncouple itself from its creationist, and thus religious, antecedents.
It cost the Dover Area School District over $1 million to defend this lawsuit, money that probably could have been spent on textbooks, teachers, and new computers. I believe in the aftermath, all school board members who supported the teaching of Intelligent design were ousted by voters. That’s how democracy I suppose.
The bill states:
If scientific theory concerning biological origin is taught in a course of study, biological evolution and biological intelligent design shall be taught. Other scientific theory or theories of origin may be taught.
Just a tiny point, and I can’t expect much out of Missouri’s legislators, but the theory of evolution does not discuss the origin of life. The theory of abiogenesis does, and that’s more chemistry and physics than biologists. Biological evolution, or modern evolutionary synthesis, is based on a mountain of evidence. The theory isn’t used in the sense of a random guess, but a scientific one with a foundation in scientific method and piles of evidence. It is falsifiable (but has not been falsified) and has itself evolved into a power predictor of how populations of organisms change over time.
Intelligent design is not falsifiable (in that it requires an all powerful creator) and is not scientific. It is based on no evidence, just ideology and rhetoric. It fails as science once the bright light of criticism is shone on it.
Well, I don’t know how Missouri’s legislature is organized, but I hope they’re intelligent enough not to do this. But if they do, expect several lawsuits. And they’ll lose them all.
I use Twitter not only to tweet about my favorite sports teams, but to see what’s being said in science, medicine, politics, and anything interesting. I actually have a list (you can read by list if you want) that I call “Pseudoscience” that are tweets from the biggest anti-science medical people around. Today, I received the following tweet:
So that lead me to a post at “Natural News” (OK, I’ll admit that my skeptical radar fired up) entitled, “Medical journal openly questions science, ethics of HPV vaccinations.” As an aside, Natural News’ url for the article is “vaccinations_quack_science_medical_journals.html”; not very subtle are they?
First a little background is necessary before starting this story. Gardasil (Merck’s brand name) is a vaccine against human papillomavirus (HPV), a sexually transmitted virus. In early stages, HPV only results in mild symptoms like warts in the genital and anal areas, but in some cases can lead to cervical cancers. The vaccine not only prevents the transmission of the disease but seems to reduce the long-term risks of cancer.
But, I digress. Imagine my reaction to the article. “Oh no, HPV vaccinations are unethical!!!!!” Call the police. I’ve been all wrong about vaccines. Oh wait, let me look up the original article, because even very unbiased news sources like the Wall Street Journal and New York Times sometimes get medicine wrong. Let me run over to the article before I post my mea culpa about vaccines.
The article, Human papillomavirus (HPV) vaccine policy and evidence-based medicine: Are they at odds?, published in the Annals of Medicine in December 2011. The authors, Tomljenovic and Shaw are associated with the University of British Columbia, Department of Ophthalmology. I don’t want to degenerate into some sort strawman fallacy, but I question why two individuals in a medical specialty, ostensibly involved with the eyes, are so obsessed with vaccines. Furthermore, they have a long history of anti-vaccination papers, most published in low impact journals. For example, they recently published an article correlating aluminum with autism, though the correlation is specious and providing no causality. One of the worst mistakes of research is conflating causality and correlation.
Moving on to the article, their abstract states:
All drugs are associated with some risks of adverse reactions. Because vaccines represent a special category of drugs, generally given to healthy individuals, uncertain benefits mean that only a small level of risk for adverse reactions is acceptable. Furthermore, medical ethics demand that vaccination should be carried out with the participant’s full and informed consent. This necessitates an objective disclosure of the known or foreseeable vaccination benefits and risks. The way in which HPV vaccines are often promoted to women indicates that such disclosure is not always given from the basis of the best available knowledge. For example, while the world’s leading medical authorities state that HPV vaccines are an important cervical cancer prevention tool, clinical trials show no evidence that HPV vaccination can protect against cervical cancer. Similarly, contrary to claims that cervical cancer is the second most common cancer in women worldwide, existing data show that this only applies to developing countries. In the Western world cervical cancer is a rare disease with mortality rates that are several times lower than the rate of reported serious adverse reactions (including deaths) from HPV vaccination. Future vaccination policies should adhere more rigorously to evidence-based medicine and ethical guidelines for informed consent.
I won’t go through each point, but a couple are important to refute:
- Uncertain benefits. The Centers for Disease Control disagrees.
- Clinical trials show no evidence that HPV vaccination can protect against cervical cancer. This is partially true, since HPV-related cancers can take from 15-25 years to arise. Epidemiological data takes time. However, we know that HPV is the cause for several types of cervical and other cancers, so preventing HPV is a logical choice to make, given the prevalence of the virus.
- Vaccination polices should adhere more rigorously to evidence-based medicine. It does already. Pretty strongly. Anti-vaccination, as best as I can tell, is based on fraudulent journal articles (see anything by Andrew Wakefield).
HPV vaccine is safe and efficacious. If you need more information on the HPV vaccine safety, the good researchers at Science Based Medicine did a great article called, The HPV Vaccine (Gardasil) Safety Revisited.
Let me make this clear. Every single medical procedure, pharmaceutical, and device has some risk associated with it. Can you get an infection at the injection site? Yes! Can you be allergic to the injection? Yes! Can it cause paralysis? No. Can it cause a broken leg? No, though if you did a random study, you’d find a large percentage of young girls who broke their legs within six months of being vaccinated, so obviously correlation is equivalent to causation. Or it doesn’t.
If Tomljenovic and Shaw could prove either no benefit with some measurable risk, or little benefit with large risk, then there is an ethical issue with the HPV vaccine. But actually, there is a high level of benefit with almost no risk, or risk that actually is imaginary rather than shown in evidence based medicine. You see, just because you use “evidence-based” in your article title, it doesn’t mean you actually follow it.
HPV vaccine should be recommended for all young men and women (yes, I said men too), reducing the future risk of cancer and it’s burden to the family, individual and health-care system.
No, it doesn’t have to do with covered bridges, old growth forests, or a vintage Harley-Davidson motorcycle.
Hostess, makers of Twinkies (immortalized in the since debunked urban myth that they have an indefinite shelf life), Ding Dongs and other comfort foods, is part of the culture of America. You drive into any convenience store, and there are shelves of the stuff. I admit to not either liking or having a Twinkie in years (quite possibly since college), but I know exactly how they taste.
And Eastman Kodak, once the power of Rochester, NY, and whose ubiquitous yellow and red film was everywhere. Now, we think of film as being quaint (though in Hollywood, Kodak still makes a significant percentage of film stock, since many top filmmakers still prefer film to digital). I learned how to develop Ektachrome and Kodachrome slides, taking almost all my photos on slides up until the early 2000’s. In fact, I was cleaning out some old boxes, and I found several rolls of exposed Kodachrome, which I could have developed, but the cost was too high, and given the 10 year old age, I wasn’t sure that I’d get good quality.
Anyways, these two brand names are part of the cultural memory of the United States. But they are disappearing, for Hostess, because we should be eating less processed, high sugar foods, and Kodak, because they stumbled in the transition from analog to digital (though they hold many of the key patents in digital photography and filmmaking).
I guess Whole Foods and Apple are their replacements these days, but they’ll be replaced by something new and better when the next generation replaces us.
Polling pastors on evolution–National Center for Science Education
There are a few interesting points regarding this poll:
- The poll was commissioned by LifeWay Christian Resources of the Southern Baptist Convention, a rather conservative Christian denomination. I’m concerned about the inherent bias.
- Protestants in various parts of the country have different beliefs about science and evolution. This poll may be biased towards Southern US churches, where more literal beliefs in biblical myth is more prevalent.
- Of course, this polling does not include anyone outside of the US.
- The first question was “I believe god used evolution created people”. About 24% agreed with that, over 72% disagreed. Of course, that’s a loaded question, because a pastor might accept evolution and not think a god was involved, but it’s hard to tell without the real data.
- Interestingly, only 46% thought the earth was 6000 years old, whereas 43% disagreed (although, not sure if they thought it was 4.5 billion or something else).
- One minor, but very annoying point. One does not believe in evolution, since belief implies acceptance with or in spite of evidence. Evolution is a theory (and in science, a theory is essentially a fact) based on mountains of evidence. It does not require evidence, it requires acceptance of the evidence, or rejection of the evidence based on denialism, ignorance, or belief in an alternative explanation–or all three.
There are churches that accept evolution as is. Jews, Catholics, and most mainstream Protestants (such as Anglicans) were, of course, excluded from this poll, and would have skewed it toward “pastors” supporting evolution. Of course, anti-evolution (or evolution denialism) is so prevalent these days, we probably shouldn’t be surprised by this poll.
By the way, if you aren’t, follow the National Center for Science Education. They keep everyone updated on important issues in science education in the USA.