2012 Top Ten list for new drug approvals

pharmaceutical researchThe US Food and Drug Administration recently announced (pdf) that it had cleared 35 new drugs during 2012, of which 31 were novel therapies. This is in addition to the literally hundreds of approvals for changes in already approved drugs for changes in packaging, manufacturing, and dozens of other reasons. 

In no particular order, here are the top 10 most interesting of the approvals based on my subjective viewpoint, which includes innovativeness, seriousness of disease, and other random factors. In others, no different in importance than all those end-of-year top 10 movie lists. So here we go:
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How science deniers use false equivalency to pretend there’s a debate

Science vs BSIf you read a news article, Google a scientific topic, or watch TV, you’d think that some scientific principles were actually being debated by scientists. From listening to the screaming and yelling, you’t think that scientists aren’t sure about evolution, vaccines, global warming, and the age of the earth (or even the age of the universe). There are even those who think there’s a debate that HIV doesn’t cause AIDS.

Part of the problem is that the public falls for the false equivalency logical fallacy. They think that to be balanced, both sides of a scientific argument are equivalent in quality of opinion and evidence. But rarely is this true, especially in scientific principles that have been well-studied and supported by a massive amount of evidence. 

Part of the problem is that some people think that science is unapproachable and too hard to comprehend. It isn’t. Now, that doesn’t mean it’s easy, because it shouldn’t be.

To become a world class architect and designing a skyscraper isn’t easy, but we, non-architects, can observe what we see, and accept that the building isn’t going to topple over in a hurricane. Do we presume to know how the foundation has to be built to support the building? Or what materials are used to give flexibility in a wind, but strong enough to not collapse? Mostly, we don’t, we trust that there isn’t a massive conspiracy to build unsafe skyscrapers because architects are being paid off by Big Concrete to use cheaper materials. 
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Circumcision–separating science from opinion

Circumcision is one topic that certainly brings up more emotion than just about any medical procedure. In fact, the same level of rhetoric is used for and against circumcision that one hears with regards to vaccines, or even abortion. Recently, the city of San Francisco attempted to ban the practice, but a judge ruled that only the state could regulate medical procedures. During the summer, a German court banned circumcision for religious purposes, though a German court banning a Jewish practice must have blown up irony meters across the world.

In any discussion about circumcision, there is general consensus that female circumcision, or female genital mutilation, is an abhorrent non-medical procedure that is simply an anti-female procedure in many male-dominated societies. We’re not talking about that, and any comparison between male and female circumcision is a strawman argument. It is also clear that part of the anti-circumcision argument centers around secularism and atheism, because male circumcision is integral to both the practice ofJudaism and Islam. That is a valid argument, and there could even be a concern that unskilled individuals performing ritual circumcisions could cause serious complications. I personally could care less about religious rituals as long as they don’t harm anyone, so this is where we need to determine what the evidence tell us. 
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Vaccine denialists hate Bill Gates

One of the world’s leading sponsors of vaccine research and bringing healthcare (including vaccinations) to underdeveloped countries is the Bill & Melinda Gates Foundationlocated in Seattle, Washington. There is nothing more admirable and moral than a person who has built incredible wealth, and then decides to give it back to the world in a way that cannot be measure monetarily. Bill Gates’ foundation is working to eradicate polio and HIV in countries where they are the some of the leading causes of death. 
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Anti-vaccine lunatic proud to spread infection to unsuspecting children

That is a screen shot from a Facebook posting on July 14, 2012 where a mother describes how she took her child, infected with chickenpox (Varicella zoster), to a baseball game. And she bragged how she probably infected others (probably most were vaccinated, which indicates he level of understanding of immunizations). She was so proud of attempting to infect others with her son’s chickenpox that she had to tell everyone about it. The stupidity of her actions were beyond comprehension by me.
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Gates contributes $750 million to Global Fund

Gates contributes $750 million to Global Fund | Vaccine News Daily.

Bill Gates, founder and former chairman of Microsoft, is contributing a huge amount of money to the Global Fund to Fight AIDS, Tuberculosis, and Malaria.  The Global Fund provides grants (through an application process) to evidence-based  and cost-effective healthcare interventions for infectious diseases.  They are large supporter of vaccines as the primary step to prevent infectious diseases.

I’ve never been a fan of Microsoft, but I think Bill Gates’ legacy is probably going to be more about his charitable work than Microsoft Windows.  And his contribution to the Global Fund, about which there are unsubstantiated rumors (my assumption is that Gates wouldn’t have contributed $1.00 if they were true) regarding their finances, is critical to their strategy of eliminating infectious diseases.  Global Fund’s success is documented:

New HIV infections are declining in many of the countries most affected by the epidemic. More and more countries are in a position to target the elimination of malaria from their territories. The world is on course to halve TB mortality by 2015 in comparison with 1990.

Since its inception in 2002, the Global Fund to Fight AIDS, Tuberculosis and Malaria has been a major engine driving this remarkable progress.

We should applaud Bill Gates and the Global Fund.

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