“False balanced” reporting of autism-vaccine manufactroversy

In the real world of science-based medicine, the link between autism and vaccines (particularly, the MMR vaccine for measles, mumps and rubella) has been thoroughly debunked, quashed, and discredited. In the delusional world of the vaccine denialists, the link between autism and vaccines is based on MrAndy Wakefield‘s paper alleging a connection between MMR and autism that has been retracted by the Lancet medical journal.

Then why is there even a debate about this manufactroversy (a manufactured or invented controversy)? Well, researchers actually examined this false controversy in a recently published article, by Graham Dixon and Christopher Clarke of Cornell University, in Health Education Research. They investigated how the news media and journalists try to “falsely balance” their reporting about the debunked link between vaccines and autism. The journalists create this false balance, “despite a strong medical and scientific consensus backed by rigorous epidemiological studies indicating no link between autism and vaccines.” Dixon and Clarke also state that “research suggests that journalists in the United Kingdom and United States often report this controversy by presenting claims both for and against a link in a relatively ‘balanced’ fashion. In some cases, so-called ‘falsely balanced’ reporting fails to mention which claim is supported by a scientific consensus.” An overwhelming scientific consensus, by the way.
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Big Pharma supports the antivaccine movement–the real conspiracy

Expensive medicineOne of the ongoing memes, beliefs and fabrications of the vaccine deniers is somehow, somewhere, in some Big Pharma boardroom, a group of men in suits choose the next vaccine in some magical way, and foist it upon the world just to make billions of dollars. And while magically concocting the vaccine brew, these pharmaceutical execs ignore ethics and morals just to make a profit on hapless victims worldwide.

The vaccine deniers pollute the internet with their screeds about the profits of vaccines. One of them said, “measles expert Offit has already made millions of dollars profit from his ties to vaccines and the measles MMR vaccine maker Merck.” Using a childish ad hominem, the article calls him, Dr. Paul “For Profit” Offit. Seriously, that’s how you’re going to “prove” that vaccines are a Big Pharma conspiracy? 

You can find whole threads of tedious commentary about vaccine profits on any typical anti-vaccine forum. One of the more illogical claims is that “maybe vax companies see vaccines as more of an investment? Break mostly even on what the vaxes cost to make and sell, but make a bank load of money on treating all the chronic problems they cause!” Of course, that would be a business strategy that would be laughed out of the secret Big Pharma boardroom, because they know that vaccines don’t cause chronic problems. The vaccines prevent it. 
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Consequences of not vaccinating–Report 3

Vaccines already savedIf you don’t follow the news out of Wales on a regular basis, then you might not know that that there is an epidemic of measles in that part of the UK. According to Public Health-Wales, there have been 886 cases of measles from 1 November 2012 through 22 April 2013. This compares to around 0-3 cases per year in the late 90′s and early 00′s. The numbers have slowly risen to peak at 159 cases in 2009. The slow increase in number of measles cases correlates with the drop in MMR vaccine uptake to around 89% by age 5, far below the 95% level that Public Health-Wales has established for MMR vaccinations.

Measles (also called rubeola, not to be confused with rubella, or German measles) is a respiratory disease caused by the measles virus. Measles virus normally grows in the cells that line the back of the throat and lungs. Measles is spread through respiration (contact with fluids from an infected person’s nose and mouth, either directly or through aerosol transmission), and is highly contagious—90% of people without immunity sharing living space with an infected person will catch it. There is no specific treatment for the disease.
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Consequences of not vaccinating a child–Report 2

Angelina at five, just before onset of SSPE

I am creating a new series, “Consequences of not vaccinating a child”, documenting individual or large group cases, where children are specifically harmed by not being vaccinated. I first published this story in May 2012, but I thought it would be fitting to republish it now, along with some updates.

One of the memes of the vaccine denialists is that childhood diseases, like measles or whooping cough, are not dangerous. In fact, some parents have set up “pox parties” to deliberately expose their children to these diseases, because anti-vaccine lunatics believe (with all evidence against their beliefs, typical of any science denialist) that natural immunity is better than a vaccine induced immunity. Not only is that an Appeal to Nature fallacy, but it shows ignorance on how immunity occurs. 

Measles (also called rubeola, not to be confused with rubella, or German measles) is a respiratory disease caused by the measles virus. Measles virus normally grows in the cells that line the back of the throat and lungs. Measles is spread through respiration (contact with fluids from an infected person’s nose and mouth, either directly or through aerosol transmission), and is highly contagious—90% of people without immunity sharing living space with an infected person will catch it. There is no specific treatment for the disease.

Even though vaccine denialists will claim that measles is not dangerous, not backed up with evidence, it is actually a fairly dangerous disease. According to the CDC, some of the complications of measles are:

About 30% of measles cases develop one or more complications, including:

  • Pneumonia, which is the complication that is most often the cause of death in young children.
  • Ear infections occur in about 1 in 10 measles cases and permanent loss of hearing can result.
  • Diarrhea is reported in about 8% of cases.

These complications are more common among children under 5 years of age and adults over 20 years old (usually those with lapsed immunity).

Even in previously healthy children, measles can be a serious illness requiring hospitalization. As many as 1 out of every 20 children with measles gets pneumonia, and about 1 child in every 1,000 who get measles will develop encephalitis. (This is an inflammation of the brain that can lead to convulsions, and can leave the child deaf or mentally retarded.) For every 1,000 children who get measles, 1 or 2 will die from it. Measles also can make a pregnant woman have a miscarriage, give birth prematurely, or have a low-birth-weight baby.

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Andrew Wakefield–you sir are a disgusting, vile excuse for a human being

mmr-lancet-stfrontpageA large outbreak (or epidemic) of measles has hit over 700 people in Wales over the past few weeks according to NHS Wales. And since there are 6000 children who are unvaccinated against measles in this area, the outbreak will continue to increase in size, since measles is a highly contagious disease. This type of epidemic should not be happening in a modern, advanced country like the UK.

Well, who or what is to blame for ? Well, according to a UK newspaper, The Telegraph, “what actually caused the drop in vaccination uptake which led to Swansea was the autism scare, started and repeatedly stoked by Wakefield, abetted (it must be admitted) by the media.” Yes, that MrAndy Wakefield whose fraudulent paper alleging a connection between MMR and autism which was retracted by the Lancet, is at fault here.
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Consequences of not vaccinating a child–Report 1

pox partyVaccine deniers love to say that many (and some say all) vaccine preventable diseases are not dangerous, so why even take a tiny risk of an adverse event with vaccines to prevent these innocuous, harmless diseases. The problem with that belief is that it is simply untrue.

The CDC reported last week about a previously healthy 15 year old girl in Ohio who died from a chickenpox (Varicella zoster virus), a disease that is generally prevented by the varicella vaccine. The adolescent girl was admitted to a hospital after three days of a rash consistent with chickenpox with the last day experiencing fever and shortness of breath. The young girls was started on antibiotics and antifungals, to treat any concurrent infections, but she died three weeks later. The girl was current (or close to current) on her other vaccinations, MMR, DTaP, and Hib, but lived in an area that with low uptake of varicella vaccinations. Because deaths from chickenpox are so rare (about 100 people die of chickenpox every year in the USA), but not unknown, the Ohio Department of Health undertook a thorough investigation and concluded that the girl died from chickenpox, and there were no other comorbidities, including leukemia (which might have suppressed her immune system).

The complications from chickenpox occur mostly in susceptible groups such as infants, pregnant women, and immunocompromised individuals. Some of the more serious complications are:

  • dehydration
  • pneumonia
  • bleeding problems
  • infection or inflammation of the brain (encephalitis, cerebellar ataxia)
  • bacterial infections of the skin and soft tissues in children including Group A streptococcal infections
  • blood stream infections (sepsis)
  • toxic shock syndrome
  • bone infections
  • joint infections

It was very difficult to read the article. Most of the young girl’s organs failed, and she was in respiratory distress when she died. I cannot imagine being a parent watching what happened over three weeks while she was in the hospital. I can only imagine that the parents are beating themselves up over not having her vaccinated.

For those parents who are engaging in Pox Parties, where parents deliberately infect their children with flu, chickenpox and other vaccine-preventable diseases, understand that you might be putting your child at risk of dying. Please don’t do it.

Vaccines do save lives. 

Use the Science-based Vaccine Search Engine.

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The one study to rule them all–the vaccine denier’s dream

clinprc(3)If you spend any time in the “debate” (actually, one side has scientific evidence and the antivaccination side denies all science, so to avoid falling for a false equivalency, debate gets scare quotes), you’ll hear every dumb argument to deny science. But one thing that you’ll see repeatedly from the vaccine deniers is that they would support vaccinations if there were better clinical trials

The problem with the vaccine denier’s clinical trial proposals is that they are a moving target, relying on a form of the Argument from ignorance, claiming that if we can’t absolutely “prove” that vaccines are safe, then it must be absolutely unsafe. For example, there are dozens of articles, including one of the latest (published here and discussed here). 

My good friend Allison Hagood, co-author of Your Baby’s Best Shot: Why Vaccines Are Safe and Save Lives, wrote a commentary about the antivaccine community’s perfect clinical trial. Follow along! (Allison’s commentary is presented in whole, but I’ve edited the formatting and added links where necessary).
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Risk of autism is NOT increased with “too many vaccines”

wakefieldThe myth of vaccines causing autism is based upon the fraudulent claims of Mr. Andy Wakefield, which caused the original article making said claims to be retracted by The Lancet. Despite this fraud, Wakefield’s acolytes, minions, and disciples in the vaccine denialist world continue to make the claim that vaccines cause autism. But there are over 250 studies that show that vaccines do not cause autism. And there is a boatload of evidence that the MMR vaccine, specifically mentioned in Wakefield’s original study, does not cause autism.

But one of the enduring myths of the vaccine denialist crowd is that it’s not just MMR vaccine that causes autism, but it’s the number of vaccines of all types that are given to children in a short period of time (pdf). Even though the best scientific evidence supports the hypothesis that vaccines do not cause autism, approximately one-third of parents continue to express concern that vaccines may cause autism, and nearly 1 in 10 parents refuse or delay vaccinations because they believe it is safer than following CDC vaccine schedule.
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Measles outbreak in South Wales, UK

note-measlesPublic Health Wales has reported an outbreak of almost 190 reported cases of measles in South Wales since November 2012. They are focusing their investigation in Swansea and Neath Port Talbot, where 189 cases have been confirmed. Cases have been notified in 32 secondary and primary schools and nurseries across the area, with 20 cases notified in the last week alone. 

According to Dr Marion Lyons, Director of Health Protection for Public Health Wales, stated that “people most at risk of catching measles are children of school age who have not had two doses of MMR. We estimate that there are more than 8,500 school age children at risk of measles in the ABMU area at present due to their MMR status.  Children should have their immunisation record, including MMR status, checked at the beginning of primary and secondary school and on leaving secondary school. We cannot emphasise enough that measles is an illness that can kill, or leave patients with permanent complications including severe brain damage, and the only protection is two doses of the MMR vaccination.”

The only protection against measles is the MMR vaccination. There are no other methods to protect a child from measles, other than isolation in a bubble against an outbreak. And despite the fraudulent claims of Mr. Andrew Wakefield and  his acolytes, minions, and disciples, the MMR vaccine is safe and effective. And it does not cause autism.

Measles is just so contagious, that one unvaccinated child with the infection can pass it to nearly anyone that lacks immunity to the disease. An infected child can walk into a pediatrician’s office, where there may be infants who are too young for the vaccination, and pass it to them. Measles is not just a simple disease with a few red spots on your skin.  It can lead to more serious complications like encephalitis and corneal scarring.  In fact, complications are more frequent and severe in older teenagers and young adults (even if healthy), so the need for vaccination has significant benefits even if you’re an adult.

In general, about 30% of children who contract measles develop a more serious complication such as diarrhea, ear infections (leading to deafness) and pneumonia. About 5% of cases require hospitalization from pneumonia, about 1 in 1000 will contract encephalitis, and 1-2 out of a 1000 who get measles dies. Measles kills over 1 million children per year. And these risks are about the same for adults who contract the disease.

Many children are unvaccinated in South Wales. Maybe it’s because they believe the false information promoted by Wakefield and other vaccine deniers. Maybe they forgot to update or complete the vaccination series. Maybe they can’t afford the vaccine (though I don’t think that’s an issue in the UK’s public health system.) It’s the lack of immunized children that have caused this outbreak. Hopefully, parents will see the scientific truth and protect their children.

Vaccines Save Lives.

Visit the Science-based Vaccine Search Engine.

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How vaccines have reduced diseases in one easy graphic

Information graphic on the results of vaccine use in the United States from Leon Farrant, 2013.

Information graphic on the results of vaccine use in the United States from Leon Farrant, 2013.

If there was any doubt about the success of vaccines this graphic shows it clearly. We can eliminate confounding variables such as improved sanitation, since many of these diseases (if not most) are not dependent upon the quality of sanitation, and are merely transmitted from individual to individual. We can eliminate the improvement in health care (other than the obvious one of the accessibility of vaccines) because improved health care wouldn’t prevent most of these diseases.

As a result of vaccines, we have eliminated polio, smallpox and diphtheria in the United States. Many other diseases, measles, mumpsrubella, tetanus, and  Haemophilus influenzae type b, are nearly eliminated. Though some people in the antivaccination world would make you believe that these diseases are not serious (the pox party is a perfect example of this belief), most of these diseases have known serious consequences for a statistically significant portion of those who get the disease. These adverse consequences may be as minor as hospitalization to as serious as life long chronic health issues or death.

In approximately one generation, modern medical science has radically changed the risks that children face to these diseases. For that, we parents should be grateful

Vaccines Save Lives.

Visit the Science-based Vaccine Search Engine.

 

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Repeated contact with mumps may overwhelm immunization

A recent study, published in The New England Journal of Medicine, concluded that after an intense face-to-face educational technique, used among Orthodox Jews, apparently led to an outbreak of mumps in 2009 and 2010, despite high vaccination rates in the group. In a one-year period, from June 28, 2009, through June 27, 2010, 3,502 cases of mumps were reported in New Jersey, New York City and New York’s Orange and Rockland counties. The study examined 1,648 of those cases, 97% were Orthodox Jews, and found 89% had received two doses of the vaccine and 8% received one dose, a relatively high rate of vaccination.

Many of the individuals attended a religious school where they practiced an intense training technique called chavruta, which involves close contact with a partner across a narrow table. Partners change frequently, and he discussion is often loud and may involve shouting since a larger group may be close to each other, all trying to make an argument or point. This prolonged contact overwhelmed the immunity, from the mumps vaccination (part of the MMR vaccine), for individuals. The study did find high rates of two-dose coverage reduced the severity of the disease and the transmission to people in settings of less exposure. Also, the study found that mumps did not spread outside of the Orthodox Jewish community in the area, further supporting the overall effectiveness of the mumps vaccine in the broader community.
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Measles case confirmed at New York state school

The Dutchess County (NY) Department of Health, in New York’s mid-Hudson Valley, have confirmed a measles case at the Mountain Laurel Waldorf School in New Paltz, NY. The local Departments of Health are recommending that anyone “who has visited this school since September 10th or has had any contact with anyone from this school should immediately make sure that they are up to date with their measles vaccinations.  All medical practices and laboratories in the area should be on high alert that there may be a number of other children and families who have been exposed and could be communicable.”

Nirav R. Shah, the New York state health commissioner, has stated that almost half of the students have not received measles immunizations (MMR vaccine).  Measles immunization is a requirement in the state, but private schools have the authority to make exceptions. The kindergarten and elementary, which has slightly more than 130 students enrolled, is a private school is located in the New Paltz college community. 
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Measles vaccine may be more effective if administered slightly later

A new research study published in Clinical Infectious Diseases has demonstrated that the MMR vaccine (measles, mumps and rubella) was more effective in teenagers who received their first dose of the two dose series at 15 months rather than at 12 months. The study was based on a more than 750 cases in 2011 of measles were reported in Quebec, Canada. Those individuals had received the routine 2-dose measles immunization schedule which is given at 12 and 18 months of age, which had been in effect in Quebec since 1996. This study assessed the effectiveness of this schedule during this outbreak that occurred during high school.
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New research shows vaccine denialists put others at risk

In a recent article published in the American Journal of Public Health, Exposure of California Kindergartners to Students With Personal Belief Exemptions From Mandated School Entry Vaccinations, by Alison Buttenheim, Malia Jones, and Yelena Baras, parents worried about the safety of vaccinations have caused a new problem in the comeback childhood diseases that haven’t been seen in a couple of generations. Buttenheim et al. wrote that a greater number of parents are refusing to get their children vaccinated through legally binding person belief exemptions, and explained that this increases the risk of infection for those with compromised immune systems and those who cannot get vaccinations. Traditionally, these individuals relied upon herd immunity, which describes a form of immunity that occurs when the vaccination of a significant portion of a population (or herd) provides a measure of protection for individuals who have not developed immunity.
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Failure of vaccine denialism–most US kindergarten students are vaccinated

The United States Centers for Disease Control and Prevention in its Morbidity and Mortality Weekly Report (MMWR) for August 24, 2012 reported that most kindergartners in the United States received their recommended vaccines for measles and other diseases during the 2011-12 school year but that unvaccinated clusters continue to pose a health risk. Overall, 47 states and DC reported 2011–12 school vaccination coverage, median MMR vaccination coverage was 94.8%, with a range of 86.8% in Colorado to 99.3% in Texas. Four states reported <90% MMR vaccination rates: Colorado, Idaho, Kansas and Pennsylvania.
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The importance of Cochrane Reviews to science based medicine (updated)

Cochrane Collaboration Copyrighted from the Cochrane Collaboration

The Cochrane Collaboration is a critically important source in evidence-based medicine, and a useful tool in providing analytical evidence that can debunk pseudoscientific beliefs. Cochrane’s goal is to organize research data and publications in an logical way that helps physicians and researchers make appropriate decisions about a proposed new therapy, medication or clinical idea. Cochrane Reviews are:

…are systematic reviews of primary research in human health care and health policy, and are internationally recognised as the highest standard in evidence-based health care. They investigate the effects of interventions for prevention, treatment and rehabilitation. They also assess the accuracy of a diagnostic test for a given condition in a specific patient group and setting.

Each systematic review addresses a clearly formulated question; for example: Can antibiotics help in alleviating the symptoms of a sore throat? All the existing primary research on a topic that meets certain criteria is searched for and collated, and then assessed using stringent guidelines, to establish whether or not there is conclusive evidence about a specific treatment. The reviews are updated regularly, ensuring that treatment decisions can be based on the most up-to-date and reliable evidence.
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Chicken vaccine viruses recombine in wild, anti-vaccine conspiracies abound

For the past five years, there have been large outbreaks of infectious laryngotracheitis (ILT) in chickens in Australia. ILT is a highly contagious herpesvirus, and one of a group that includes herpes and chickenpox. The chickens become very ill with red and swollen eyes, along with sneezing, coughing and gasping, while occasionally producing a bloody nasal discharge. Mortality is quite high, and surviving chickens produce fewer eggs, which, of course, is very bad for chicken farmers.

The diseases are usually prevented by a vaccine against ILT. Many vaccines against viruses, including the ILT version, contain live attenuated viruses (LAV), which are viruses that have reduced virulence, though still alive, so that the immune system recognizes it to develop an immune response. Attenuation takes an infectious agent and alters it so that it becomes harmless or less virulent.
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Manufacturing a controversy about the MMR vaccine

Here we go again with the trope that the MMR vaccine causes autism. The Daily Mail, a British middle market tabloid, has published an article, MMR: A mother’s victory: The vast majority of doctors say there is no link between the triple jab and autism, but could an Italian court case reignite this controversial debate?, that is attempting to create a controversy out of thin air about the MMR vaccine for mumps, measles and rubella. The article is referring to an insane Italian court ruling which, despite all evidence to the contrary, blamed a child’s autism on the vaccination. 
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Measles-outbreak in England hits new areas

Ten measles cases since the start of 2012 has hit St. Helens, a town in the northwest English county of Merseyside, making it the most widespread measles outbreak in the area since the 1980s. There have been 301 confirmed cases, along with 148 probable cases, of measles in Merseyside since the beginning of 2012.

According to a report in the St. Helens Reporter newspaper, Dr Roberto Vivancos, a consultant in communicable disease control with the Health Protection Agency, stated:

This has been the largest outbreak of measles in the North West since the introduction of MMR vaccine 24 years ago and it has demonstrated just why this vaccine is so important in protecting the public health. Parents of young children clearly value the protection, security and peace of mind that the MMR vaccine affords, but there remains a pool of older children, teenagers and young adults who are not vaccinated and remain vulnerable to measles, mumps and German measles. Our message to older teenagers and young adults is that if you were not vaccinated as children, it’s not too late. You should speak to your family doctor about the MMR vaccine because, without its protection, you will remain vulnerable to three potentially very serious diseases.

As I’ve mentioned before, parents should not consider measles a trivial disease. It can be deadly. Unvaccinated adults or older children can infect an infant prior to the chilling being vaccinated with the MMR vaccine. Everyone should be vaccinated, even if older.

Vaccines save lives.

via St. Helens hit by measles outbreak | Vaccine News Daily.

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Measles–outbreak in England grows

 

Child with measles rash after 3 days. Credit to Centers for Disease Control.

As reported earlier, Merseyside, a city in northwest England, is experiencing a significant measles out break. The number of confirmed cases in Merseyside has exceeded 300, making it the largest measles outbreak in the that part of England since 1988.

According to the BBC, there have been 301 confirmed measles cases in the area, 90 of which are in teenagers. Although the number of children who receive the MMR vaccine for measles, mumps and rubella has reached an all-time high, young adults and teenagers are still at risk, according to the BBC.
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