Gardasil safety and efficacy – debunking the HPV vaccine myths

Gardasil safety and efficacy

There was an article published in Pediatrics that described how educating either teenagers or their parents about HPV vaccinations had little effect on the overall vaccination rate for the vaccine. Essentially, the researchers found that it was a 50:50 probability that any teen would get the vaccine, regardless of their knowledge of HPV and the vaccine itself. Some of the reasons why the HPV vaccine uptake is so low is a result of several myths about Gardasil safety and efficacy.

So I thought about why that Pediatrics study found that education about HPV and Gardasil didn’t move the needle on vaccination uptake. It’s possible that the benefits of the vaccine is overwhelmed by two factors–first, that there’s a disconnect between personal activities today vs. a disease that may or may not show up 20-30 years from now; and second, that the invented concerns about the HPV quadrivalent vaccine, promulgated by the usual suspects in the antivaccination world, makes people think that there is a clear risk from the vaccine which is not balanced by preventing cancer decades from now. It’s frustrating. Continue reading “Gardasil safety and efficacy – debunking the HPV vaccine myths”

Dorit Rubinstein Reiss – an index of contributions to this website

Dorit Rubinstein Reiss

Dorit Rubinstein Reiss – Professor of Law at the University of California Hastings College of the Law (San Francisco, CA) – is a frequent contributor to this and many other blogs, providing in-depth, and intellectually stimulating, articles about vaccines (generally, but sometimes moving to other areas of medicine), social policy and the law. Her articles usually unwind the complexities of legal issues with vaccinations and legal policies, such as mandatory vaccination and exemptions, with facts and citations. I know a lot of writers out there will link to one of her articles here as a sort of primary source to tear down a bogus antivaccine message.

Professor Reiss writes extensively in law journals about the social and legal policies of vaccination–she really is a well-published expert in this area of vaccine policy, and doesn’t stand on the pulpit with a veneer of Argument from Authority, but is actually an authority. Additionally, Reiss is also member of the Parent Advisory Board of Voices for Vaccines, a parent-led organization that supports and advocates for on-time vaccination and the reduction of vaccine-preventable disease.

Below is a list of articles that Dorit Rubinstein Reiss has written for this blog, organized into some arbitrary and somewhat broad categories for easy reference. This article will be updated as new articles from Professor Reiss are added here.

Continue reading “Dorit Rubinstein Reiss – an index of contributions to this website”

GMO science facts – your one stop shop

gmo science facts

Genetically modified organisms (GMOs or GMs) are one of the most well studied areas of biological and agricultural research. However, one of the tactics of the GMO refusers is that “there’s no proof that GMOs are safe.” It’s time to look at the GMO science facts – examining myth from science.

Typically, in a debate, the side making the assertion (those that say GMOs are unsafe) are responsible for the evidence that supports their contention. But, the anti-GMO gang relies upon the argument from ignorance, trying to force the argument to “if you can’t prove that they’re safe, they must be unsafe.”

The anti-GMO forces also like to invoke the precautionary principle, which attempts to shift the burden of proof to those who are advocating GMOs (or any new technology) until the advocates “prove” that there are absolutely no negative consequences of using GMOs.

The principle is often cited by anti-science and/or environmental activists when there is a perceived lack of evidence showing that a technology is absolutely safe.

I’ve written numerous articles about GMOs, focusing on scientific evidence supported by high quality research. And more than a few articles debunked myths and bad research from the anti-GMO crowd. To assist those who are doing research on the topic, this article was created to be a one-stop shop for GMO science facts – and fiction.

Continue reading “GMO science facts – your one stop shop”

Aluminum adjuvants in vaccines – another attempt for something, anything

aluminum adjuvants

Here we go again, another attempt to link aluminum adjuvants in vaccines to something, despite the lack of real evidence for anything. Recently, an attempt by the disreputable pair of anti-vaccine researchers to show a link between aluminum adjuvants and autism was retracted by the journal.

Several researchers have proposed a systematic review (which are considered to be the pinnacle of the hierarchy of biomedical research) to determine if there are any links between aluminum adjuvants in vaccines to some medical condition. Read that carefully – this paper does not provide any new evidence, it is merely a description of their reasons for looking at aluminum along with the meta review protocol.

Mostly, I’d ignore these type of papers, because they aren’t providing us with any new information about vaccines. But in this case, I wanted to point out a bunch of flaws in their reasoning, which seems to indicate a high degree of bias. Therein is the problem – systematic reviews are powerful tools in science based medicine, but many of these systematic reviews are filled with a large amount of bias. And this study is starting from a very biased point of view. Continue reading “Aluminum adjuvants in vaccines – another attempt for something, anything”

Cervical cancer vaccine – Gardasil 9 shows long-term effectiveness

cervical cancer vaccine

One of the myths of the anti-vaccine crowd is that we don’t know anything about the long-term effectiveness of the HPV vaccine. Of course, the vaccine was launched in most of the world in 2008, although there is a large pool of women who received the vaccine during the earlier clinical trials, so it will take time to determine long-term effectiveness. A peer-reviewed article was recently published that confirms the long-term efficacy of the cervical cancer vaccine, Gardasil 9.

Each year, we probably will see new articles published that will continue to confirm the effectiveness of the cervical cancer vaccine years after injection. So far, we see no decrease in effectiveness of the vaccine, providing us with solid evidence that it will provide long-term protection against the dangerous cancer-causing virus, thereby preventing HPV-related cancers.

I know this data will not stop the misinformation and false claims about Gardasil. That won’t stop me from discussing this important research. Continue reading “Cervical cancer vaccine – Gardasil 9 shows long-term effectiveness”

GMO bananas – necessary to save the fruit from extinction

GMO bananas

People love their bananas, one of the most popular fruits consumed in the world. We generally only eat one banana cultivar, the Cavendish, which replaced another cultivar that was susceptible to Panama disease, a type of Fusarium wilt. Unfortunately, the Cavendish banana has been devastated by a new form of that fungal disease which might lead to the end of the availability of the banana in your local grocery store. But there is hope – scientists are developing GMO bananas that may save the fruit from becoming a distant memory.

Let’s take a look at how the banana industry got here and how GMO bananas may be the salvation for the delicious yellow fruit. Continue reading “GMO bananas – necessary to save the fruit from extinction”

Physicians for Informed Consent – another radical anti-vaccine group

Physician for Informed Consent

There are a bunch of anti-vaccine groups out there who invent legitimate sounding names in an attempt to appear to be rational, positive organizations. They’re mostly neither rational nor positive. A new one (at least for me) is a group called the “Physicians for Informed Consent,” whose “vision is to live in a society free of mandatory vaccination laws.”

Although there are individuals who are pro-vaccine but are opposed to mandatory vaccination, mostly on a politically libertarian point of view, almost all of these groups, especially in California, are specifically anti-vaccine. In fact, “informed consent” is one of those veiled code-words used by the anti-vaccine world, especially in the fight against SB277, California’s recently enacted law that removes personal belief exemptions to vaccinations for school age children.

This article is going to examine some of the issues around “informed consent,” then look at a recent statement from the radical anti-vaccine gourd, Physicians for Informed Consent. Continue reading “Physicians for Informed Consent – another radical anti-vaccine group”

Vaccines and autism – science says they are unrelated

vaccines and autism

Vaccines and autism are not linked or related according to real science, published in real scientific journals written by top scientists and physicians.

But this false claim is in the news again. Probably as a result of reports that more and more children are being diagnosed with autism spectrum disorders. So let’s take a look at the science.

On 28 March 2014, the United States Centers for Disease Control and Prevention (CDC) announced that new data show that the estimated number of children identified with autism spectrum disorder (ASD), a disorder of neural development, usually appearing before the age of 3 years, characterized by impaired social interaction and verbal and non-verbal communication, and by restricted, repetitive or stereotyped behavior, continues to rise.  The picture of ASD in US communities is changing. Continue reading “Vaccines and autism – science says they are unrelated”

Andrew Wakefield discredited – a collection of his attacks on vaccines

Andrew Wakefield discredited

Between Dorit Rubinstein Reiss and I, we have written over 100 articles about that cunning fraud, Andrew Wakefield. Are you going to find anything positive about him in any of those +100 articles? No way. Is Andrew Wakefield discredited as a physician, scientist, and vaccine expert? You bet.

Why are we so obsessed with pointing out that he has been discredited? Because he has become, through media manipulation and many anti-vaccine acolytes and sycophants, the face of the “vaccines cause autism” meme. Note to the casual reader – there is absolutely no evidence that vaccines cause autism.

Is Andrew Wakefield discredited? Damn straight he is.

Mr. Wakefield is no doctor. He has been stricken off the list of physicians in the UK which is tantamount to having his license to practice medicine revoked. Because he is no longer a physician, he can no longer be found in the Royal College of Surgeons.

And let’s not forget that Wakefield’s article, that made him a hero to the antivaccine crowd, in the Lancet was disowned by his coauthors and eventually retracted by the journal. Interesting little bit of trivia – the very first article (other than a welcome-test article) I ever wrote on here was about Wakefield.

Just to make life easier for those of you researching Andrew Wakefield and his various frauds, I’ve organized many of my posts into categories. Have fun debunking the basket of deplorables.  Continue reading “Andrew Wakefield discredited – a collection of his attacks on vaccines”

Anti-vaccine paper retracted – Shaw and Tomljenovic lose again

Anti-vaccine paper retracted

A few weeks ago, I wrote a critical analysis of a paper by Christopher Shaw and Lucija Tomljenovic published in Inorganic Biochemistry that tried to convince us that aluminum adjuvants in vaccines caused autism. Predictably, it’s another anti-vaccine paper retracted by another journal.

Shaw and Tomljenovic have quite a history in retracted anti-vaccine articles. Last year, they wrote an article about aluminum adjuvants in the HPV vaccine – it was retracted, and eventually republished almost word-for-word in an inferior journal.

According to Retraction Watch, Inorganic Biochemistry’s editor, John Dawson of the University of South Carolina, stated that:

The paper by Shaw and co-workers is being retracted jointly by the authors and the editor.

Yup, another anti-vaccine paper retracted. Of course, the article was roundly criticized in numerous posts across the skeptical universe soon after it was published. For example, the piercing Orac wrote in his blog,

given Shaw and Tomljenovic’s history, it is not unreasonable to be suspicious of this study as well…

At best, what we have here are researchers with little or no expertise in very basic molecular biology techniques using old methodology that isn’t very accurate overinterpreting the differences in gene and protein levels that they found. At worst, what we have are antivaccine “researchers” who are not out for scientific accuracy but who actually want to promote the idea that vaccines cause autism….If this were a first offense, I’d give Shaw and Tomljenovic the benefit of the doubt, but this is far from their first offense.

Orac called the paper, “antivaccine pseudoscience.” Not that anti-vaccine is anything but pseudoscience.

Other bloggers, like The Mad Virologist, who is also an expert on DNA analysis, and the Blood Brain Barrier Scientist, who writes about the blood-brain barrier and heavy metal music, jointly analyzed the paper by Shaw and Tomljenovic. They did a masterful job in looking at some of the technical errors and other issues with the paper. I won’t pretend to summarize what they write, so I’ll use their own summary:

Based on the methods that were used in this paper, Shaw et al. went too far in declaring that aluminum adjuvants cause autism. But there are six other key points that limit what conclusions can be drawn from this paper:
1) They selected genes based on old literature and ignored newer publications.
2) The method for PCR quantification is imprecise and cannot be used as an absolute quantification of expression of the selected genes.
3) They used inappropriate statistical tests that are more prone to giving significant results which is possibly why they were selected.
4) Their dosing regime for the mice makes assumptions on the development of mice that are not correct.
5) They gave the mice far more aluminum sooner than the vaccine schedule exposes children to.
6) There are irregularities in both the semi-quantitative RT-PCR and Western blot data that strongly suggests that these images were fabricated. This is probably the most damning thing about the paper. If the data were manipulated and images fabricated, then the paper needs to be retracted and UBC needs to do an investigation into research misconduct by the Shaw lab.

Taken together, we cannot trust Shaw’s work here and if we were the people funding this work, we’d be incredibly ticked off because they just threw away money that could have done some good but was instead wasted frivolously. Maybe there’s a benign explanation for the irregularities that we’ve observed, but until these concerns are addressed this paper cannot be trusted.

Also, a lot of criticism occurred on PubPeer, a website devoted to a kind of extended peer review of published papers. The commenters were harsh. Oneclaimed that there was a “clear and deliberate” removal of control results in the paper. And many others either hinted or outright stated that DNA gel bands were duplicated, photoshopped or taken from a 2014 paper by Shaw and Tomljenovic (and published in a journal that’s not even indexed on PubMed).

Added to all of this is that the primary author has left the University of British Columbia, where Shaw and Tomljenovic do their “research,” taking all of the data with her. I don’t mean to be cynical, but I will be – yeah right.

As an aside, I don’t know why the University of British Columbia continues to house Shaw and Tomljenovic. They have had their “research” utterly discredited by the World Health Organization. They have had papers retracted. And when they do publish, they’re in low ranked, low impact factor journals. Finally, their “research” is supported by some of the most profoundly anti-vaccine sponsors in the world.  Frankly, the only good Shaw and Tomljenovic do for the anti-vaccine world is to allow those of us who are pro-science/pro-vaccine lots of fodder in embarrassing the anti-vaccine world.

So there we go. Another Shaw and Tomljenovic anti-vaccine paper retracted, and will probably be republished in the Journal of Homeopathy Vaccines (no, it doesn’t exist). By the way, I won the betting pool on when it would be retracted. Hopefully, the shills pay me for winning.

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