Cancer vaccines — they exist and you should get them

Viruses cause over 20% of cancer cases worldwide — and it should be celebrated that we have vaccines that can prevent some of those cancers. Considering the fear that many people have of cancer, getting these vaccines should be a high priority.

Part of the reason that these cancer vaccines are not a high priority is probably that cancer may not appear until long after the viral infection. If cancer appeared soon after the virus attacks, the cause and effect would be very clear, probably making the vaccine a much higher priority.

This article is going to focus on preventative cancer vaccines. There are cancer vaccines that are being developed as treatments for cancer — for example, there is a new mRNA vaccine that may be useful in treating colorectal cancer.

These “cancer vaccines” train the immune system, much like preventative vaccines, to attack existent cancer but they cannot prevent it. Furthermore, these types of vaccines are individually designed for each patient — in essence, unique antigens on the cancer cell surface are isolated and used to induce the immune system to attack the cancer cells. It’s a therapeutic technique that will still be used in conjunction with surgery and other adjuvant therapies like chemotherapy.

I might discuss this type of “cancer vaccines” more in the future as they become more prevalent, but for this article, I am going to be discussing preventative cancer vaccines.

view of operating room
Photo by Pixabay on Pexels.com

Cancer-causing viruses

Of the 22 distinct families of viruses, five of these families are called “persisting,” because the virus remains in the body for life. One example is the varicella-zoster virus which causes chickenpox in children. However, it persists in the body and can reappear later in life in a more dangerous form called shingles.

Seven known viruses can cause cancer:

All of these viruses, except for the two hepatitis viruses, are members of persistent virus families. These persistent viruses contain genetic code that teaches cells how to avoid cell death. This leads to immortalizing those infected cells and promoting cell growth, important characteristics of cancer. The cancer cells that develop from these viruses contain not only the original genetic code for the cell, but also include genetic code from the virus itself.

Just to be clear, only a small proportion of people who are infected by one of these persistent viruses will develop cancer associated with it. But this is true for almost all carcinogens — you will never find that 100% of individuals who have been exposed to a cancer-causing agent will develop cancer.

The other two viruses, hepatitis B and hepatitis C, are different than the persisting viruses. Most individuals’ immune systems can fight the infection and eventually eliminate the virus. However, some people are not able to fight the infection, possibly because of a suppressed immune system, long-term infections can cause extensive damage to the liver. These people have a higher risk of developing a type of liver cancer called hepatocellular carcinoma because the body’s attempts to repair the damaged liver cells increase the chance of a cancer-related mutation in the genetic code. As opposed to persisting viruses, the viruses themselves do not cause the liver cells to become immortal or promote cell growth.

These cancers are dangerous:

These cancers are dangerous and deadly. But here is the thing — they are preventable.

people taking a photo
Photo by Cori Rodriguez on Pexels.com

Cancer-preventing vaccines

We can prevent these hepatitis- and HPV-related cancers with readily available, safe, and effective vaccines.

Merck manufactures Gardasil, which was first approved in 2006, probably the most popular HPV vaccine in the world. The first version of the vaccine, quadrivalent Gardasil, targets the two HPV genotypes known to cause about 70% of cervical cancer and two other HPV genotypes that cause genital warts. In Europe and other markets, Gardasil is known as Silgard.

The newer Gardasil 9, approved by the FDA in 2014, is a 9-valent vaccine, protecting against HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58. It targets the four HPV strains found in the quadrivalent version, along with five additional ones that are linked to cervical and other HPV-related cancers. Both versions of Gardasil are prophylactic, meant to be given to females or males before they become exposed to possible HPV infection through intimate contact.

Despite the claims of the anti-vaccine world, like the misinformation from Robert F Kennedy Jr, the HPV vaccine is extremely safe and extremely effective. Cervical cancer rates have dropped precipitously in countries that have broad coverage from the HPV vaccine.

The hepatitis B vaccine has been was introduced in 1986 and was recognized as the first anti-cancer vaccine. Like the HPV vaccine, it is extremely safe and extremely effective. Unfortunately, like the HPV vaccine, there has been a lot of anti-vaccine disinformation about the hepatitis B vaccine, almost all of it false.

I have written that there are just a handful of ways to prevent cancer — consuming a daily dose of kale-blueberry smoothies is not going to reduce your risk of cancer. However, the cancer-preventing vaccines, for HPV and hepatitis B, can substantially reduce your risk of some dangerous and deadly cancers.

I don’t understand any level of vaccine resistance, but it has gotten worse during this pandemic. However, given the fear of cancer in people, I don’t quite understand why people would refuse surefire prevention to a large number of cancers.

Citations


________________________________________________
Please comment below, positive or negative. Of course, if you find spelling errors, tell me! And share this article.

There are two ways you can help me out to keep this website awesome. First, you can make a monthly contribution through Patreon:

Become a Patron!

Buy ANYTHING from Amazon.

Best Medical Blogs Worth Following - OnToplist.com
close

Don’t miss each new article!

We don’t spam! Read our privacy policy for more info.

The Original Skeptical Raptor
Chief Executive Officer at SkepticalRaptor
Lifetime lover of science, especially biomedical research. Spent years in academics, business development, research, and traveling the world shilling for Big Pharma. I love sports, mostly college basketball and football, hockey, and baseball. I enjoy great food and intelligent conversation. And a delicious morning coffee!