Vaccinated children sicker – another anti-vaccine trope

vaccinated kids sicker

One of the enduring zombie myths pushed by the anti-vaccine side is that their children are healthier than vaccinated children. But are vaccinated children sicker? Not based on any real, scientific evidence. But that never stops the science denying anti-vaccine crowd.

The vaccine myth website, vaccines.news published an article recently pointed to two poorly designed studies to make the outlandish claim that vaccinated kids are sicker. One the studies, a German one, which used internet surveys (yeah, think about that) to get data,  was pushed by several anti-vaccine groups, including the propaganda blog, Age of Autism, as “proof” vaccines are dangerous. But as the silver-tongued Orac concluded:

In any case, I take some comfort in the hilarious result of this survey that demonstrates that autism prevalence in the unvaccinated is similar to autism prevalence among the vaccinated, no matter how much anti-vaccine activists try to spin it otherwise. I realize that this survey is in fact so poorly designed that it really doesn’t tell us much of anything, but it is fun watching anti-vaxer brains explode trying to spin this result as supporting the vaccine/autism hypothesis.

Remember, there is no scientific evidence supporting the vaccine/autism hypothesis.

Now we have a new study that barely rises to the same abhorrent quality level of the aforementioned German study. Of course, we have to look at it.

Vaccinated children sicker – the research behind the myth

The claims that are circulating across the anti-vaccine blogosphere are based on a recent article published in the Journal of Translational Science. Before we get into the article, you might be wondering what is “translational science,” because it sounds a bit woo-based. Translational medicine or science is an interdisciplinary approach which combines resources, expertise, and techniques within basic sciences to discover enhancements in prevention, diagnosis and therapies for various diseases. It’s actually pulling medicine back to basic sciences to better understand everything going on in the body.

For example, they may discover a mutated gene that produces a dysfunctional protein that has a profound effect on the body. They then target that gene and its protein production to treat the disease, rather than target the symptoms that are caused by the bad protein. Translational medicine is an exciting field of biomedical research, on which has shown much promise. However, some “translational medicine” has moved into the world of woo.

Here’s what the Journal of Translational Science (JTS) says its goals are:

JTS is a novel journal that will focus upon the translation of cellular, molecular, and genetic pathways into clinical strategies for multiple medical disciplines that can impact a broad spectrum of disorders that involve stem cells, degenerative diseases, aging, immune function, tumorigenesis, epigenetics, musculoskeletal function, cognition, behavior, neuronal, cardiac, pulmonary, gastrointestinal, and vascular targets, and metabolic function overseeing all aspects of translational research and medicine.  JTS will provide a platform in today’s scientific and medical literature to serve as an international forum for the healthcare and scientific communities worldwide to translate novel “bench to bedside” science into clinical therapies as well as report upon prognostics, novel therapeutic strategies, and biomarker development.

That’s all well and good, but the study from JTS that we’re discussing in this post doesn’t fit in any of those. And a review of much of the research they publish is laughably woo-based. In the same issue of JTS as the article we’re discussing, they had published an article examining traditional Chinese medicine, which is neither traditional nor medicine.

So, let’s take a closer look at the “vaccinated children sicker” paper.

A 10,000-meter meta-critique of the paper.

There’s a lot to dislike about this paper and journal. But I think it’s important to take a meta-approach to this paper to make sure you have a good grasp of the quality of what we’re critiquing.

  1. The Journal of Translational Science is not indexed in PubMed. It’s been over two years since the journal was first published, and it is rare for a journal to not be indexed there. Without PubMed, it is extraordinarily difficult to cites one of the articles published in JTS. Of course, there’s no reason given for its exclusion from PubMed, but we can speculate that possibly the science is bad.
  2. JTS lacks an impact factor. The impact factor gives us a relative understanding of the quality of a journal – generally, the impact factor tells us approximately how many times an average article published in a journal is cited per year. A journal like Nature has an impact factor of 36, which means the average article is cited 36 times a year. Why is this important? We know that more pivotal and valuable research is cited many times and often repeated by other scientists, especially in new publications. This is how science develops solid evidence, by examining and repeating the findings of others.
  3. The publisher of JTS, OAT, is a predatory publisher according to the definitive Beall’s List of predatory publishers. A predatory publisher is “exploitative open-access publishing business model that involves charging publication fees to authors without providing the editorial and publishing services associated with legitimate journals.”
  4. Low impact factor, predatory journals are generally dismissed by scientific researchers because the peer-review is weak. These journals are often abused by researchers whose data has been rejected by one or more of the respected journals, so they settle for these low-quality versions. In the academic community, publications such as these often cannot be used as evidence of qualification for tenure.

None of these issues alone should lead one to dismiss the data outright. However, if one had real data that leads to a conclusion that “vaccinated kids sicker – watch out,” it would have been accepted by any of the journals that have focused on vaccines. But if the research was not well-designed, and well-analyzed, then the better journals would move away, and quickly, from adding it to their publication.

Critique of the “vaccinated children sicker” paper

The authors, Anthony R Mawson et al., hypothesized that there was an association between vaccines and neurodevelopmental disorders (NDD) of 6- to 12-year old biological children. The study was of homeschooled children in Florida, Louisiana, Mississippi, and Oregon. The mothers were asked to complete an anonymous online questionnaire on their children with respect to pregnancy-related factors, birth history, vaccinations, physician-diagnosed illnesses, medications used, and health services utilized. The NDD was defined as having one or more of these diagnoses – learning disability, attention deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD).

The study found the following conditions were more prevalent in vaccination children:

  • Allergic rhinitis (odds ratio = 30.1). We’re going to take a look at odds ratio down below.
  • Other allergies (OR= 3.9)
  • Eczema/atopic dermatitis (OR=2.9)
  • Learning disability (OR=5.2)
  • ADHD (OR=4.2)
  • ASD (OR=4.2)
  • Any chronic illness (OR=2.4)

Well, all that sounds like vaccines are worse for our children. Except it really doesn’t.

How about we jump in with a harsh critique of these kinds of studies:

  1. It uses an internet questionnaire to determine each of the data points for this study. The use of questionnaires for epidemiological studies is frowned upon by many researchers. The reasons for this are many, but they include a reliance upon the memory of the participant for events that may be not be recalled correctly. In addition, there might be an intentional or unintentional bias of the survey participants towards relating a condition to vaccines or ignoring one in unvaccinated kids. Better done, and frankly, more expensive, epidemiological studies rely upon medical records to reduce errors in memory and bias. This is a critical point – the best studies that show no link between vaccines and autism rely upon actual medical data for each child, not on a questionnaire which may or may not be tracking accurate information.
  2. Homeschooled groups are unrepresentative of the school-age children at large. Many children are homeschooled because of parents dislike of vaccinations, so this forms a biased group. Now, maybe the homeschooled group mirrors a traditionally schooled group – if you want to make that case, then you need actual data published in an actual journal.
  3. Parents who do vaccinate may be less reluctant to visit their physician to get diagnosed with diseases, while a non-vaccinating parent may choose to ignore any health issues as minor. Thus, there may be an unintentional bias towards health care issues for vaccinated children.
  4. The groups (vaccinated vs. unvaccinated) are not randomized which will lead to observational and confirmation bias.
  5. The population for the study is quite small to tease out data on very rare conditions. A meta-review that included nearly 1.3 million children, using real medical records to establish both vaccination status and ASD status, found that there was no difference between vaccinated and unvaccinated groups with respect to the incidence of autism.
  6. There was a lack of analysis of potential cofounders which might bias the results. Were there other differences between he vaccinated and non-vaccinated groups that could have biased the results one way or another?
  7. The use of odds ratio by the researchers is curious and may have biased the results. The only reason to use OR is to inflate the difference between both groups. Real epidemiologists prefer relative risk (RR) which provides us with a much more sensitive understanding of the incidence of a condition in a vaccinated group vs. an unvaccinated group. For example, the RR for ASD from this study (if the data actually were useful, which it isn’t) is 3.1, whereas the OR is 4.2.
  8. The over-reliance on p-values is always a red flag to researchers. With so many p-values, the probability of false positives is fairly large. Because the population for the study was so small, it’s also worth noting that the OR had relatively large error brackets, most of which crossed near unity, that is, 1.0, indicating no difference between the groups.
  9. The authors seem to overlook or ignore the point that the vaccinated children had a much lower risk of diseases like chickenpox and measles, which we know bring with them significant risks of long-term health issues. Even if we accept this poorly designed study as providing us with evidence of harm from vaccines, one would have to balance it against the benefits of avoiding vaccine-preventable diseases. Of course, this study is so bad, it’s hard to accept anything useful from it.

Predictably, the authors conclude that:

First, additional research is needed to replicate the findings in studies with larger samples and stronger research designs. Second, subject to replication, potentially detrimental factors associated with the vaccination schedule should be identified and addressed and underlying mechanisms better understood.

Maybe because their paper was published in a journal that is not indexed in PubMed, they didn’t search there. If they had, they would have found find 100s of articles, with much better, unbiased studies that conclude that there is no link between vaccines and neurodevelopmental disorders. I’ll simplify for Mawson et al., I reviewed and wrote an article that included the most important real science articles that they are wrong about vaccines and neurodevelopmental disorders.

Conclusion

Are vaccinated children sicker? Well, if you listen to the anti-vaccine crowd, who have cherry-picked Mawson et al. to support their pre-conceived faith that vaccines and autism are linked, you’ll buy into the anti-vaccine conclusions:

This pilot study shows us that if mainstream medicine and our public health agencies are really interested in children’s health, not just vaccine profits or defending vaccine religion against blasphemy, what is needed is not the will to make everyone believe, but the courage to find out.

But real science says that the study used by this anti-vaccination believer is poorly designed, and it does not show what they claim it shows. It’s biased, poorly analyzed, and comes to conclusions that are not supported by the vast mountains of real science published in real (read, non-predatory journals). No real scientist would accept the findings of this paper, other than to laugh heartily. I don’t laugh because I know some crackpot will use it to “prove” that vaccines are dangerous when there’s no robust evidence to support that belief.

Vaccines are safe. Vaccines are effective. A badly designed, irresponsibly published article does not change the vast consensus of scientists that vaccines are safe and effective.

Editor’s note – this article was originally published in May 2017, but for some odd reason, there were a lot of dead links that had to be rehabilitated. Also, some copyediting was required (thanks Grammarly).

Citations






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Using NVICP cases to prove vaccine-autism link – anti-vaxxers get it wrong

vaccine-autism link

In general, the anti-vaccine religion lacks any scientific evidence supporting their beliefs about vaccine safety and effectiveness. So, they have to default to using memes and tropes based on anecdotes, fake science, or decisions made by the National Vaccine Injury Compensation Plan (NVICP). A recent paper, written by Dorit Rubinstein Reiss and Rachel Heap, reviewed how NVICP cases are being used and misused by anti-vaccine forces to prove an autism-vaccine link.

Mostly, the anti-vaccine zealots use NVICP cases to attempt to convince the world that there is actual “evidence” that vaccines cause autism spectrum disorders. Of course, we know that the vast body of scientific research tells us that there is no vaccine-autism link. Professor Reiss’ article examines key NVICP cases and shows how they are being used and misused by anti-vaccine forces.

This post is going to review some of the key points presented by Professor Reiss and Ms. Heap in their published article. Of course, their article is over 70 pages long (with extensive footnoting), so I’m just going to hit the key points. However, the full article (pdf) is an important and detailed discussion of the misuse and abuse of NVICP cases in an attempt to claim that there is a vaccine-autism link. Continue reading “Using NVICP cases to prove vaccine-autism link – anti-vaxxers get it wrong”

Jenny McCarthy, with help from Oprah Winfrey, lies about vaccines

jenny mccarthy vaccines

Jenny McCarthy was once the MTV drunk college dating game hostess and former “journalist” on The View. I remember when she joined The View – there was widespread condemnation of her hiring from scientists, journalists, and yours truly because of her loud and annoying antivaccine rhetoric. Clearly, no one of any note supported her being hired on the View, except for websites like the Age of Pushing Nonsense To Harm Children. Continue reading “Jenny McCarthy, with help from Oprah Winfrey, lies about vaccines”

Prenatal vitamins during pregnancy reduce the risk of autism spectrum disorders

prenatal vitamins

If you are a regular reader of this blog, you know I’m not exactly a fan of vitamin supplements. They are expensive, and they don’t do what people want to believe they do. They do not reduce the risk of any cancer. They do not improve bone health. But I always forget to mention an important exception – prenatal vitamins and supplements that are well known to improve pregnancy outcomes.

And now it’s time for me correct this egregious oversight on the part of the feathered dinosaur’s body of work on supplements. Just to be clear, I always state an important caveat on my dismissing the usefulness of vitamins and supplements – those individuals with chronic disease or malnutrition may require supplements. For example, if you never touch a fruit or vegetable, you will probably need vitamin C to prevent scurvy. No, I didn’t say that vitamin C will prevent cancer, but it will prevent one disease.

Recently, a top peer-reviewed journal has published an article where the researchers showed that there was a lower risk of autism spectrum disorders in children of mothers who took prenatal vitamins. And I can write about one area of healthcare where some vitamins and supplements do have some value. This is more evidence that there are numerous issues that may lead to autism spectrum disorders – and it’s not vaccines. Continue reading “Prenatal vitamins during pregnancy reduce the risk of autism spectrum disorders”

Anti-vaccine pseudoscience – more bad science on autism and aluminum

anti-vaccine pseudoscience

You’ve got to hand it to the anti-vaccine pseudoscience activists – they are nothing if not dedicated to their religious beliefs. And like the so-called “creation science” religion, which tries to “prove” their evolution denialist beliefs with pseudoscience published in creationist journals, the anti-vaccine religion tries to “prove” that vaccines are dangerous with bad science, pseudoscience, and misinterpreted science.

As of today, I’ve written a dozen or so articles about Christopher Shaw and   Lucija Tomljenovic, contemptible University of British Columbia anti-vaccine pseudoscience extremists. Shaw and Tomljenovic are well known for pushing garbage science to further their anti-vaccine religion. Of course, their “scientific articles” keep getting retracted, despite being published in low ranked journals whose standards rarely exceed “please use a good spell checker.”

Now, we have a new article trying to push the myth that somehow the tiny amounts of aluminum in vaccines are related to autism. Of course, we have hundreds of real scientific articles published in real scientific journals which have demolished the myth that vaccines cause autism. But these persistent anti-vaccine pseudoscience pushers keep trying. Because one of the central tenets of pseudoscience is to have a pre-ordained conclusion, and find any evidence, irrespective of quality, to support it.

So we’re going to take a look at this new “article.” I always examine anti-vaccine “research” from two perspectives – first, I take a look at the author(s), the journal, and other factors that might have an impact on our critique of the study. Second, I then critique the scientific data, methods, and conclusions.  So, here we go, into the fray. Continue reading “Anti-vaccine pseudoscience – more bad science on autism and aluminum”

Anti-vaccine pseudoscience – Shaw and Tomljenovic debunked tropes

anti-vaccine pseudoscience

I’m beginning to feel some deja vu, since I am criticizing another anti-vaccine pseudoscience paper foisted onto the world by Christopher Shaw and Lucija Tomljenovic. These two University of British Columbia (UBC) researchers in the Department of Ophthalmology (you know, the study of eyes) have no background or training in any area vaccine research, including immunology, epidemiology, microbiology, virology or anything else remotely related. Yet they keep publishing anti-vaccine pseudoscientific junk medicine.

Yet, every time these anti-vaccine shills publish anti-vaccine pseudoscience articles in low ranked journals, the reactionaries jump all over it and try to use those articles as “science” to dismiss the scientific fact of vaccine safety and effectiveness. Except for one small matter – Shaw and Tomljenovic have a long record of retracted articles (here and here), publishing their “research” in low impact factor, predatory “pay-to-play” journals, and pushing anti-vaccine pseudoscience that has been hammered by respected scientific organizations like the World Health Organization (WHO).

Yes, many of us are wondering why UBC hasn’t tossed both of them out of the university for research malfeasance, but that’s not the point here. We’re just going to rip apart the anti-vaccine pseudoscience presented in another article from Shaw and Tomljenovic.  Continue reading “Anti-vaccine pseudoscience – Shaw and Tomljenovic debunked tropes”

Vaccines and autism – science says they are unrelated

vaccines and autism

Vaccines and autism are not linked or related according to real science, published in real scientific journals written by top scientists and physicians.

But this false claim is in the news again. Probably as a result of reports that more and more children are being diagnosed with autism spectrum disorders. So let’s take a look at the science.

On 28 March 2014, the United States Centers for Disease Control and Prevention (CDC) announced that new data show that the estimated number of children identified with autism spectrum disorder (ASD), a disorder of neural development, usually appearing before the age of 3 years, characterized by impaired social interaction and verbal and non-verbal communication, and by restricted, repetitive or stereotyped behavior, continues to rise.  The picture of ASD in US communities is changing. Continue reading “Vaccines and autism – science says they are unrelated”

Andrew Wakefield discredited – a collection of his attacks on vaccines

Andrew Wakefield discredited

Between Dorit Rubinstein Reiss and I, we have written over 100 articles about that cunning fraud, Andrew Wakefield. Are you going to find anything positive about him in any of those +100 articles? No way. Is Andrew Wakefield discredited as a physician, scientist, and vaccine expert? You bet.

Why are we so obsessed with pointing out that he has been discredited? Because he has become, through media manipulation and many anti-vaccine acolytes and sycophants, the face of the “vaccines cause autism” meme. Note to the casual reader – there is absolutely no evidence that vaccines cause autism.

Is Andrew Wakefield discredited? Damn straight he is.

Mr. Wakefield is no doctor. He has been stricken off the list of physicians in the UK which is tantamount to having his license to practice medicine revoked. Because he is no longer a physician, he can no longer be found in the Royal College of Surgeons.

And let’s not forget that Wakefield’s article, that made him a hero to the antivaccine crowd, in the Lancet was disowned by his coauthors and eventually retracted by the journal. Interesting little bit of trivia – the very first article (other than a welcome-test article) I ever wrote on here was about Wakefield.

Just to make life easier for those of you researching Andrew Wakefield and his various frauds, I’ve organized many of my posts into categories. Have fun debunking the basket of deplorables.  Continue reading “Andrew Wakefield discredited – a collection of his attacks on vaccines”

Anti-vaccine tweets correlated with affluent white women in five states

anti-vaccine tweets

Although there’s evidence that the anti-science beliefs surrounding vaccines cross a broad political spectrum, I’ve always wondered if rich white liberal women were the center of the anti-vaccine universe – this is based on my own personal anecdotal evidence, so let’s just consider that a belief than a fact. A recent analysis of anti-vaccine tweets may or may not confirm my beliefs about these rich white liberals.

There has been a dramatic increase, over the past few years, in the volume of tweets that claim that life-saving vaccines are linked to autism. Anyone who reads this blog knows that that claim is demonstrably and scientifically false. Despite the science, the belief that vaccines cause autism remains. And this view is promulgated on various locations on the internet.

Like with a lot of other controversial topics, the Twitter outrage about the danger of vaccines doesn’t actually reflect a sudden surge in anti-vaccine beliefs amongst the general population. According to a recently published peer-reviewed article, most of increase in these anti-vaccine tweets represent a very specific demographic. Individuals from affluent, populated areas in five states – California, Connecticut, Massachusetts, New York, and Pennsylvania – seem to be the backbone of this sudden increase in anti-vaccine tweets.

Let’s take a look at this new paper. It could provide us with some information about the who is pushing the anti-vaccine narrative. Continue reading “Anti-vaccine tweets correlated with affluent white women in five states”

Aluminum causes autism? Anti-vaccine Shaw and Tomljenovic UPDATED

aluminum causes autism

Every morning I wake up with the vain hope that the vaccine deniers will give up on the thoroughly debunked vaccines-cause-autism tropes. And every morning I’m disappointed. Today’s trope is that vaccine aluminum causes autism. Despite the claims, there still is no evidence.

Two of our favorite anti-vaccine shills, Christopher Shaw and Lucija Tomljenovic, have been the subject of scathing reviews numerous times by the feathery dinosaur. And they’re back again, using bad science, trying to convince the world that aluminum in vaccines is somehow linked to autism.

Well, let’s take a look at research, but don’t expect a different result when I last looked at a Shaw and Tomljenovic article about aluminum in vaccines. Which was retracted. Continue reading “Aluminum causes autism? Anti-vaccine Shaw and Tomljenovic UPDATED”