HPV vaccine adverse effects and the European Medicines Agency

HPV vaccine adverse effects

Despite the robust body of evidence supporting HPV vaccine safety and effectiveness, the European Medicines Agency (the European Union’s version of the US FDA) began a review of human papillomavirus (HPV) vaccines “to further clarify aspects of their safety profile,” although the agency also points out that this review did not “question that the benefits of HPV vaccines outweigh their risks.” In other words, the EMA examined the HPV vaccine adverse effects, real or imagined.

After a few months of investigation, the EMA came to a conclusion about HPV vaccine adverse effects – there were no major ones. Let’s take a look at this story.
Continue reading “HPV vaccine adverse effects and the European Medicines Agency”

43,000 HPV-associated cancers annually – HPV vaccine can prevent most

HPV-associated cancers

As I’ve written before, there are just a handful of ways to reduce your risk of cancer. Don’t smoke. Stay out of the sun. Keep a healthy weight. Don’t drink alcohol. And get vaccinated with the HPV vaccine to prevent HPV-associated cancers (see Note 1).

Too many people who discuss the HPV vaccine, especially among the anti-vaccine religion, tend to focus on HPV-related cervical cancer. But HPV is linked to several dangerous and deadly cancers, and a new report examines the details of those cancers.  Continue reading “43,000 HPV-associated cancers annually – HPV vaccine can prevent most”

Courts and science – talc and glyphosate probably do not cause cancer

courts and science

I’ve written about this many times before – courts do not get to decide what is good or bad science. Although courts and science may not necessarily be incompatible, attorneys, juries, and judges are generally not trained in scientific research, scientific methods, scientific publications, and/or scientific reasoning.

Two relatively recent cases are strong evidence that courts and science can be quite incompatible. In the first case, a jury ordered pharmaceutical giant Johnson and Johnson (JNJ) to pay US$4.69 billion in damages to 22 women who claimed that the company’s talcum powder products caused ovarian cancer. In the second case, a jury ordered chemical manufacturer Monsanto to pay US$289 million to a janitor who claimed that Round-Up (glyphosate) caused his terminal cancer.

The problem with both of these cases is that there is, at best, some weak, unrepeated scientific evidence that supports their claims. However, if you refrain from cherry-picking articles on PubMed, you’ll find that the vast majority of research either doesn’t support their claims or even shows that there are no links between talc or glyphosate and cancer.

Let’s take a look at the science in both of these cases, and then, let’s find out why courts and science are not necessarily compatible. And remember, this isn’t a recent problem – an American court once rejected evolution during the infamous Scopes Monkey Trial. So science has been skeptical of the involvement of courts and science for a very long time. Continue reading “Courts and science – talc and glyphosate probably do not cause cancer”

Gardasil effectiveness – yes, HPV vaccine does protect you against cancer

Gardasil effectiveness

Although I have no poll numbers sitting in front of me, and certainly no scientific peer-reviewed research, I just have a feeling that if you scratch the surface of an anti-vaccine activist, you will find that if they could hate one vaccine, it would be Gardasil. And one of the arguments will be all about Gardasil effectiveness – they claim it doesn’t actually prevent cancer.

When you couple their false claims about the dangers of the vaccine with the claims about the lack of Gardasil effectiveness, you’d probably agree with the anti-vaccine crowd. Despite these false claims, HPV vaccine uptake has slowly grown in the US and other countries.

I’ve written nearly 200 articles about the HPV cancer-preventing vaccine, but most of those are focused on debunking myths and confirming the safety of the vaccine. I’m going to focus on a quick primer about Gardasil effectiveness in preventing cancer. Stay tuned for some interesting science. Continue reading “Gardasil effectiveness – yes, HPV vaccine does protect you against cancer”

Cervical cancer rate declines after introduction of HPV vaccine – new evidence

cervical cancer rate

One of the misinformed tropes of the anti-vaccine world is that there is no evidence that the human papillomavirus (HPV) vaccine actually reduces cancer rates. Given that the vaccine was only introduced in the last 10 years, it would take time for researchers to study this issue. But now, we have more evidence that the cervical cancer rate declined after the introduction of the HPV vaccine in the USA.

We have robust evidence that the HPV vaccine actually stops HPV infections, which are linked to several types of cancer. Over the past few years, a number of published articles have provided us with powerful evidence that the HPV vaccine is significantly reducing the cervical cancer rate.

Although there is a myth that the HPV vaccine is just to prevent cervical cancer, I expect, over the next few years, there will be new research that shows reductions in other cancers, in both women and men, as a result of the introduction of the vaccine. Moreover, the effect of the vaccine on males may take longer since the vaccine was recommended for males only a few years after it was introduced.

This year, a solid systematic review, the most powerful research in the hierarchy of biomedical science, along with other studies, have been published that provide strong evidence that the HPV vaccine reduces the cervical cancer rate. Now we have a new study to add to the body of science supporting the effectiveness in preventing cancers of the HPV vaccine. Continue reading “Cervical cancer rate declines after introduction of HPV vaccine – new evidence”

HPV vaccine could prevent 41,000 cancers a year – Gardasil works

HPV vaccine

I do repeat myself repeatedly, I admit, especially about cancer. There are really only a handful of ways to lower your risk of cancer – stop smoking, stay out of the sun, eat a “healthy” diet, keep a healthy weight, don’t drink alcohol, and a few other things. One of those few science-based methods to stave off cancer is getting vaccinated against cancer-causing viruses. The HPV vaccine and hepatitis B vaccine (see Note 1) are some of the most powerful tools in cancer prevention.

The Centers for Disease Control and Prevention (CDC) have published a detailed report of HPV-related cancers in the USA, and it states that there are over 41,000 HPV-related cancers diagnosed every year. The National Cancer Institute categorizes “common cancers” as those with over 40,000 new cases a year – if we could lump all of these HPV-related cancers into one group, it would be considered a common cancer, contradicting the anti-vaccine memes that HPV isn’t that dangerous.

And the HPV vaccine could prevent most of those cancers by blocking the HPV types that cause those cancers. Continue reading “HPV vaccine could prevent 41,000 cancers a year – Gardasil works”

Cancer mortality rates – mostly great news in war on cancer

cancer-mortality-rates

Despite the cancer tropes that seem to afflict Facebook and Twitter these days, which includes the laughable “Big Pharma is hiding a secret cancer cure” myth, recently published evidence shows that cancer mortality rates in the USA are dropping. This is great news if you’re wondering if cancer is an end-of-life diagnosis – science-based medicine is attacking and beating cancer with numerous strategies for each cancer. And yes, instead of hiding cancer cures, Big Pharma is providing a lot of the successful medications in treating the disease.

The report, published in the journal Cancer by researchers at the American Cancer Society, the Centers for Disease Control and Prevention, the National Cancer Institute, and the North American Association of Central Cancer Registries, provides us with the mostly good news. Cancer mortality rates, which describes the number of cancer deaths per 100,000 people per year, have dropped significantly in the USA. This drop includes most of the common cancers, such as lung, colorectal, breast, and prostate.

Unfortunately, the news isn’t all good – some cancer mortality rates have increased, and I will try to explain why. Let’s take a look at cancer and this new paper. Continue reading “Cancer mortality rates – mostly great news in war on cancer”

Marijuana medical benefits – large review finds very few

Marijuana medical benefits

Most states in the USA, and many countries across the world have passed legislation that allows the use of marijuana for medical purposes. Some of this legislation is dependent on various claims, many of which appear to be based on weak or nonexistent scientific evidence. Of all of the purported marijuana medical benefits, only a handful are supported by real evidence.

This review, Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda (pdf, which can be downloaded for free by registering or can be found online here), published by the influential and prestigious National Academies of Science, Engineering, and Medicine, examined more than ten thousand scientific studies that involved cannabis and various medical conditions. The value of such a review is that it examines not only the quantity of evidence supporting a claim but also the quality of such evidence. In the end, it gives much more weight to high-quality evidence.

I know many comments will drop on this article that “you haven’t read that incredible study published in Journal of Weed and Cancer Cures” – that misses the point. The National Academies is a highly respected institution, made up of the most respected scientists in the USA. And the committee that created this review is made up of leading public health, cancer, epidemiology, pharmacology, and psychiatry, all fields germane to understanding clinical and basic scientific research into cannabis.

Moreover, a review like this does two things – it gives more weight to well done clinical trials and pre-clinical studies, and it eliminates poorly done and biased studies. This is how science works – examine ALL of the evidence before coming to a conclusion. Pseudoscience, on the other hand, is to have a conclusion, like “weed cures cancer,” and only seeking evidence that supports that preordained conclusion.

Furthermore, and this cannot be stressed enough, this review is not opinion. It is not belief. It is not cherry picking. It is a critical analysis based on thousands of studies published in peer-reviewed journals. This is not published in a pro-cannabis website that cherry picks, misinterprets, and overrates a one-off study in an obscure journal. The report is over 400 pages long – most of you will not read even a few pages, because it is a dense scientific review written by some of the top scientists in the USA. Before you denigrate the study, I would suggest you read it carefully.

To save you time from reading the 400+ page opus, which I did, I divided up the medical evidence from strong to none of the evidence in support of benefits and of risks from smoking cannabis. Not to bury the lede, but there are only three conditions for which there is strong, overwhelming evidence benefits of marijuana. Just three. Continue reading “Marijuana medical benefits – large review finds very few”

HPV vaccine prevents cervical cancer – a systematic review

HPV vaccine prevents cervical cancer

One of the many tropes about HPV vaccine from the anti-vaccine religion is that the vaccine has no effect on any cancer. Recently, I wrote an article that outlined the evidence that supports a link between HPV vaccines and cancer – that is, the vaccine does lower the risk of cancer. After I wrote that article, a new systematic review was published that, indeed, the HPV vaccine prevents cervical cancer.

Many people think that cancer is some sort of on/off switch – in fact, HPV-related cancers may take years or decades to be diagnosed. However, it’s been 8-12 years since the vaccine has been available (depending on the country), so a population of young women (the vaccine was only indicated for women in most countries until a few years ago) is now getting to the age where they may be diagnosed with either cancer or pre-cancerous lesions.

As the population of women (and eventually men) reaches the age where risks of certain cancers are increased, we can use epidemiological studies to determine whether or not there is a difference in cancer risk between vaccinated and unvaccinated groups. Let’s review the systematic review that examined a surprisingly large number of studies that support the fact that the HPV vaccine prevents cervical cancer. Continue reading “HPV vaccine prevents cervical cancer – a systematic review”

HPV vaccine prevents cancer despite anti-vaccine fear, uncertainty, doubt

HPV vaccine prevents cancer

The fear, uncertainty, and doubt (FUD) campaign, a disinformation tool used by the anti-vaccine religion for propaganda purposes, against the HPV vaccine would laughable if the lies didn’t put our young people at risk for cancer in the future. We already have circumstantial evidence that the HPV vaccine prevents cancer – but now we’re accumulating robust direct evidence that it can stop HPV-related cancers.

Despite the claims of anti-vaccine pseudoscientists, who spend their time trying to invent false claims about vaccine safety, HPV vaccine safety is nearly settled science, based on dozens of high quality clinical and epidemiological studies. Although the anti-vaccine religion would love you to believe that the vaccine kills their children, the scientific evidence decidedly refutes these assertions.

Anti-vaccine zealots illogically reject any circumstantial evidence that the HPV vaccine prevents cancer.  That circumstantial evidence is based on powerful data that the vaccine prevents many strains of HPV infections, and we have similarly powerful data that many cancers are directly related to those same HPV infections – thus, if you stop the infection, it’s logical to accept that the vaccine will stop cancer. At least the logic makes sense to scientists, but apparently logic isn’t a top priority of pseudoscientific vaccine deniers.

Because HPV-related cancers can take years to show up – it’s a myth that cancers have some on-off switch that the causal factor instantly makes cancer appear – direct evidence has been difficult to research on whether HPV vaccines prevent cancer. But the HPV vaccine has been on the market for 10-15 years in most areas of the world, so if our hypothesis is correct, that the HPV vaccine prevents cancer, then maybe we can see a direct reduction in these cancers by now.

Guess what? We do have some of that direct evidence. Continue reading “HPV vaccine prevents cancer despite anti-vaccine fear, uncertainty, doubt”