Category: Evidence based medicine

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Part 6. Medical uses for cannabis – the TL;DR version

This is Part 6  of a series of six articles discussing various medical uses for cannabis or marijuana. In this part, I summarize all of the five previous articles into some bullet points so that you have quick and fast access to some scientific information about medical uses for cannabis or marijuana.

In case you missed them, here are the first five articles in this series:

Part 1. Marijuana and medicine assessing the science.

Part 2. Marijuana and cancer – assessing the science

Part 3. Marijuana and neurological disorders – assessing the science

Part 4. Marijuana and health risks – assessing the science

Part 5. Marijuana and pregnancy – assessing the science

Maybe you don’t agree with the science about marijuana’s role in medicine. But that’s not how science works. The evidence should lead you to a conclusion (actually, the acceptance or rejection of a hypothesis). One shouldn’t form an a prior conclusion, then go hunt for data. That’s not how it works.

As new systematic or meta reviews bring more clinical evidence of the benefits of the medical uses for cannabis – this takes time – maybe evidence based medicine can incorporate marijuana into the armamentarium of medical practice. But only real clinical evidence matters.

So let’s review where the evidence leads us. Continue reading “Part 6. Medical uses for cannabis – the TL;DR version”

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Part 3. Marijuana and neurological disorders – assessing the science

This is Part 3  of a series of six articles discussing marijuana’s use in medicine and health care. In this part, we discuss marijuana and neurological disorders – probably the only field of study regarding medical uses of cannabis that has a robust area of clinical research.

Although research into the use of marijuana and cancer takes all the news these days, there is probably just as vigorous research into neurological disorders.  If you read the story regarding CNN’s chief medical correspondent, Dr. Sanjay Gupta, who claimed he changed his mind about marijuana, you’d know he was also convinced that marijuana had some great potential in mental health. But is there really any high quality evidence?

In this article, I’ll look at some of the more prominent claims, along with a skeptical analysis of those claims. Continue reading “Part 3. Marijuana and neurological disorders – assessing the science”

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Part 4. Marijuana and health risks – assessing the science

This is Part 4  of a series of six articles discussing marijuana’s use in medicine and health care. In this part, we discuss marijuana and health risks – even if there is evidence that marijuana had medical benefits, there must be a review of the risks of using it.

Only in junk medicine (see homeopathy or chiropractic, for example) is there a promise of great results with no risks. In real medicine, all benefits are balanced against the real risks of any medication or procedure.

The whole foundation of evidence (or science) based medicine is science – “it is the only set of methods for investigating and understanding the natural world.” Thus, the best factual evidence includes clinical research that describes not only the effectiveness, but also the risks, of a particular medical procedure.

In this article, I’ll look at marijuana and health risks – along with a skeptical analysis of those claims. Continue reading “Part 4. Marijuana and health risks – assessing the science”

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Misinformation, lies, and memes from the anti vaccine cult

I do yeoman’s work reading the stupidity on the internet so you don’t have to do it yourself. Some of it makes me feel unclean–I hate that I contribute to the google rankings of some of these websites by even clicking on these websites.

The Age of Inventing Stuff about Autism is one of the most offensive of the anti vaccine cult websites, although that ranking changes depending on what is posted. It’s not just me who thinks they’re bad, but Skeptoid considers it one of the Top Ten Worst Anti-science Websites.   Continue reading “Misinformation, lies, and memes from the anti vaccine cult”

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The one vaccine clinical trial design to rule them all

If you spend time observing the “vaccine debate” (it’s not a debate), you’ll hear every dumb argument to deny science. But one thing that you’ll see repeatedly from the antivaccination cults are that they would support vaccinations if there were better vaccine clinical trial design.

The problem with the cult’s demand for better vaccine clinical trial design is really one of several moving targets for their denialism, relying on a form of the Argument from ignorance, claiming that if we can’t absolutely “prove” that vaccines are safe, then it must be absolutely unsafe.

For example, there are literally thousands of articles,  ( an example here and was discussed here), that actually provide overwhelming evidence of the safety and effectiveness of vaccines using real science, real statistics, and real hard work. The antithesis of the fake science, bogus statistics, and 2 hours of Google.

Continue reading “The one vaccine clinical trial design to rule them all”

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How can homeopathy help to stop the Ebola outbreak?

homeopathy-waterIn case you’re assuming that it can, it really can’t.

Since any reasonable person would understand that homeopathy violates some of the basic principles of physics, chemistry and biology. And because there is no viable mechanism that would make you think homeopathy actually could work, clinical trials show that it doesn’t work, or, at best, it is a mythical placebo. So, if it doesn’t work in clinical trials, and there is no possible mechanism underlying it, employing Occam’s Razor, we would have to say the simplest explanation is the best: Homeopathy does not work. It’s a lie. It’s a scam. Period. End of story.

The current outbreak of the Ebola virus in West Africa has been making significant headlines lately. The virus is deadly, with a mortality rate well over 90%, easily transmitted by any bodily fluid, and there is no known cure. The course of the disease is horrifying, starting with symptoms similar to a bad flu, but eventually leading to blood clotting problems, failing organs like the kidney and liver, then finally death. The disease is not selective about whom it attacks, young or old, healthy or not.

Early treatment may increase the survival chance, since there is no known cure. Treatment focuses on replenishing fluids, maintaining proper blood pressure, replacing lost blood, and treating related infections.

And there is no vaccine to prevent the virus from infecting individuals. This isn’t a massive conspiracy to prevent a new vaccine from coming to the market. Developing the vaccine has been incredibly difficult because traditional vaccine development strategies, such as inactivation, have not been successful. In fact, several vaccines have shown to be successful in preventing Ebola infection in animals and non-human primates, but as I’ve said many times, success in animals only rarely translates to success in humans. Those vaccines that have shown promise are now undergoing substantial clinical trials, but human clinical trials for vaccines are complex and take time. In fact, there might Ebola vaccines available in the next few months.
Continue reading “How can homeopathy help to stop the Ebola outbreak?”

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Do you believe in treating cancer with alternative medicine?

Recently, I saw a question on Quora, in which the author asked, “Do you believe in treating cancer with natural regimens?” In a landslide, the best answer, which is chosen by the readers, was one written by a UCLA medical school graduate and Fellow in Oncology at Stanford University School of Medicine, Dr. David Chan. In other words, Dr. Chan is a cancer expert who actually spent 10-12 years of his life gaining an education in treating cancers (instead of like 30 minutes Googling junk medicine). Continue reading “Do you believe in treating cancer with alternative medicine?”

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Despite the meme on Facebook, bananas do not cure cancer

a-ripe-banana-a-day-keeps-cancer-infection-at-bay

This article was published on 29 July 2012, and has had over 70,000 views. This is the number one article I’ve ever written, I enjoyed writing it, but I never thought it would be such a big hit. It basically arose from a meme I saw on Facebook that claimed that bananas with dark spots had anti-cancer compounds in it. And it was all based on a misreading of a published article, a lack of knowledge about tumor necrosis factor, and a complete misunderstanding of human physiology and immunology. And this is my number 1 favorite, and number 1 most popular article for 2013.

 

Note: this article was rewritten and revised–please read and comment on the updated version of this article.

 

Last year, I wrote an article about how to critically analyze pseudoscience and misinformation to get at the scientific evidence which may help you accept or reject something you might read on the internet, even if it appeared to be accurate. On Facebook, Twitter and many internet sites (including Wikipedia), there is an amazing tendency of individuals to accept what is written as “the truth” without spending the effort to determine if what is written is based on accurate science. Twitter, of course, limits itself to 140 characters, which means you either have to click on a link to get more information, or just accept that the 140 characters are factual. And if you can make a complex scientific argument in 140 characters, I’m impressed.

Facebook is filled with false memes on just about everything from politics to medicine. The anti-vaccination crowd fills Facebook with their amusing and highly inaccurate memes. For more than a year, there have been dozens of  photos of bananas with a few words that some Japanese scientists claim that ripe bananas have high levels of “tumor necrosis factor“, so eat bananas to cure cancer and maintain a healthy immune system. Facebook is famous for these things, little pictures with a few words, no sources of the information, and broad conclusions. Eat bananas. Cure cancer. And people share them with a click of the button and move on to the next cute cat picture. It’s really the lazy person’s way of learning. Although who doesn’t enjoy the cute cat pictures? Continue reading “Despite the meme on Facebook, bananas do not cure cancer”

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Supplements to treat the common cold–myth vs science

cold-cureIt’s getting colder outside, and if you go into any pharmacy, grocery store, chemist, or superstore, you will find literally a dozen or more homeopathic, herbal, or other unproven lotions and potions to prevent or treat the common cold, or rhinovirus. These supplements are a significant part of the annual US$108 billion dollar supplement/nutraceutical industry. 

These alternative medicine (so named because there is no scientific evidence supporting their efficacy, let alone safety) products make claims that are so wonderful, many people take them. Then they themselves tell their friends how fast they got rid of their cold. Or that their cold wasn’t as bad after taking the supplement.

The problem is that determine the length and severity of the course of the common cold is entirely subjective. Since the disease is rather mild with few serious complications, it’s hard to determine when it exactly stopped and started, and how bad it was.  The common cold tends to resolve itself without external help, but there really isn’t much you can do to make your immune system attack that cold faster.

 

Continue reading “Supplements to treat the common cold–myth vs science”

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How pseudoscience tries to fool you

Editor’s note: This article has been updated and divided into a multi-part article. The comment section has been closed, so go to the new article if you want to make a suggestion, make a comment, disagree, or make us laugh. 

Pseudoscience is enticing partially because it’s easy and partially because it gives black and white false dichotomies about the natural world, including medicine. Pseudoscience tries to make an argument with the statement of “it’s been proven to work”, “the link is proven”, or, alternatively, they state some negative about scientifically supported therapies. It really  has an appeal to it because it digest complex analysis to a simple “yes, this works.”

For example, real science has debunked the “there is a proven link between vaccines and autism,” a common and popular pseudoscientific belief.  Or that most alternative medicine (CAM) therapies work based on numerous logical fallacies that suspends reason, and accepts “belief” in the therapy, something that evidence-based medicine just doesn’t do.

So, I decided to highlight what separates real science from pseudoscience. We’ll explore what exactly makes an idea scientific (and spoiler alert, it isn’t magic), and contrary to real science, what makes an idea “pseudoscientific.” So sit down, grab your favorite reading beverage, because this isn’t going to be a quick internet meme. I intend to show you the lies of pseudoscience, and how it’s used with creationism, vaccine denialism, alternative medicine, or whatever you want to debunk.  Continue reading “How pseudoscience tries to fool you”