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Mothers protect their newborns with 3 doses of COVID vaccine

A new study shows that mothers who have received three doses of the COVID vaccine provide better protection against the disease for their newborn babies than mothers who have received only two doses. This is more evidence that the COVID vaccine is highly effective in protecting the newborn baby against COVID.

Also, we have evidence that the COVID vaccine is safe for the developing baby. In fact, the CDC announced that it recommends the COVID-19 vaccine during pregnancy to protect the health of the mother and the developing fetus. The CDC also stated that there are “no safety concerns” among women in their third trimester and for their newborn babies.

As we usually do, I will analyze the data from this study and provide you with a summary of the results.

toddler wearing head scarf in bed COVID vaccine mothers
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COVID vaccine for mothers and newborns

In a study published on 2 January 2024 in the respected JAMA Network Open, Alisa Kachikis, MD, of the University of Washington in Seattle, and colleagues enrolled 220 pregnant individuals at the University of Washington from February 2021 through January 2023.

All participants had received at least two doses of mRNA COVID vaccine before giving birth and had no history of prior COVID infection (confirmed by the absence of anti-SARS-CoV-2 nucleocapsid antibodies at delivery). The median age of participants was 34 years, and approximately 82% were white. Among participants, 121 received two doses of an mRNA vaccine and 99 received three or more vaccine doses, before or during pregnancy.

Here are the key results:

  • For pregnant individuals, three doses of an mRNA COVID-19 vaccine resulted in 10 times higher antibody levels in umbilical cord samples of preterm and full-term deliveries compared with only two doses. In other words, mothers who received three doses of the COVID vaccine produced 10 times the antibody that protects the fetus and the newborn from the disease.
  • Concentrations of antibodies in maternal blood samples were 12 times higher in mothers who received three doses of the COVID vaccine compared to those who received only two doses.
  • The timing of the third dose was not important, as the levels of antibodies were the same despite the gestational age at which the third dose was given.


I think it’s important to note that this is a small study with only 220 participants from a local area (Seattle, WA). However, it does give some good information based on actual levels of COVID antibodies.

The differences in antibody levels between two and three COVID vaccines for pregnant mothers are huge and provide convincing evidence that three doses of the vaccine provide the highest level of protection for both the mother and the newborn baby.


Michael Simpson

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