COVID-19 vaccines pipeline – potential next emergency use authorizations

COVID-19 vaccines pipeline

After the emergency use authorizations (EUA) were given for the Moderna and Pfizer COVID-19 vaccines, what is next in the pipeline? There are three vaccines that could be reviewed by the Vaccines and Related Biological Products Advisory Committee (VRBPAC) during the next few weeks that would provide recommendations to the FDA (and other national drug regulatory bodies) for EUAs.

The three vaccines I’m going to discuss are ones that have a reasonable chance of getting approved for use in the USA or Europe. This excludes COVID-19 vaccines from Russia, China, and other countries that rarely, if ever, get FDA approval for vaccines (see Note 1).

So, let’s take a look at what are probably the next three COVID-19 vaccines in the pipeline.

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Will the Pfizer Moderna AstraZeneca COVID-19 vaccines end the pandemic?

Pfizer Moderna AstraZeneca COVID-19 vaccines

There has been a lot of excitement lately with the Pfizer/BioNTech, Moderna, and AstraZeneca/Oxford COVID-19 vaccines lately, but I wanted to temper your enthusiasm thinking the pandemic is going to be over in a few weeks, and we can all hit the pub, drinking with our friends, family, and neighbors. 

If anything, I would strongly recommend wearing a face mask across the world until a substantial number of people are vaccinated, and that may take a lot longer than you thought. By the way, more recent scientific evidence supports the FACT that when both individuals are masked, there is almost no transmission of viruses. 

So, let me explain why, despite the good news, we still need to protect ourselves from the coronavirus. There is light at the end of the tunnel, but don’t be confused by the recent announcements by Pfizer, AstraZeneca, and Moderna regarding their COVID-19 vaccines – there is still a lot of hard work to be done.

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AstraZeneca COVID-19 vaccine shows 70% effectiveness in phase 3

astrazeneca COVID-19 vaccine

AstraZeneca has announced that its COVID-19 vaccine has exhibited over 70% average effectiveness in phase 3 clinical trials in Brazil and the United Kingdom. The vaccine was initially developed by the University of Oxford, but AstraZeneca will manufacture and distribute the vaccine worldwide.

The AstraZeneca COVID-19 vaccine is the third vaccine over the past few days that has shown extremely high effectiveness following the ones announced by Pfizer and Moderna. However, the AstraZeneca/Oxford vaccine is substantially different in pharmacology and distribution than the other two. 

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Vaccine development process in the world of a coronavirus pandemic

Back before the world of the COVID-19 pandemic, the vaccine development process took a long time. Despite the nonsensical claims of the anti-vaccine zealots, the vaccine development process was robust and thorough. The safety and effectiveness of all of the pre-pandemic vaccines are settled science (read the article before you jump up and down screaming about “settled science”).  

However, the world of the coronavirus pandemic means that if we can save a few months or even years off the development timeline on a new COVID-19 vaccine, it could save hundreds of thousands of lives. This does not mean those political agendas like we’ve seen Trump do with hydroxychloroquine and other things should take precedence over good science. 

So, this article is going to lay out how, in a world without a pandemic, the coronavirus vaccine development process should proceed while ignoring how the politically-driven FDA may subvert the process

Although I am very uncomfortable with the coronavirus vaccine development process over the past few months, it looks like, for better or worse, we’ll probably have one or two different vaccines in unknown quantities by early 2021. 

Of course, much of the optimism comes from experts like Dr. Anthony Fauci, one of the few rational public health experts who are willing to speak up in Washington DC. Maybe he has seen some secret data only available only to him and Bill Gates that supports this optimism. Maybe he just is trying to be the national cheerleader for healthcare.

I don’t know the real answer, but a lot of vaccine experts who have spent their lifetime studying vaccines, like Dr. Peter Hotez, MD Ph.D., who has expressed dismay at how politics may “trump” good science.

So, this article will try to lay out the development process, along with the independent controls that make sure that all vaccines are safe and effective.
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