Drug development – explaining a complicated process, including vaccines

Based on some of the comments I see on the internet, I think that that people believe that drug development is easy. Anyone can do it. And all you have to do is invent a drug and, voila, it’s approved and you can make billions of dollars in gold

I might be over-exaggerating, but I’ve always thought that the anti-vaccine crowd believes in their heart that the development of vaccines includes throwing a bunch of stuff in a blender along with dollops of mercury, formaldehyde, aborted babies, and aluminum, which is poured into a vial and sold for billions of dollars. Despite those anti-vaccine myths, pharmaceutical drug development (including vaccines) is a difficult process that fails 99% of the time.

Drug and vaccine development is the total opposite of easy. It takes time, a lot of brilliant minds, and some luck. Sure, some worthless drugs do get approved (we’re eyeballing you Biogen), but almost every drug that fails to have a significant benefit to cost (in terms of safety and price) ratio will fail to get FDA approval.

The myths about drug development are filled with controversy, false claims, and conspiracy theories. Yes, occasionally, we can point out problems with the process. Unless you’re using confirmation bias, you will see that the vast majority of pharmaceuticals are very safe and very effective (or at least the benefits outweigh the risks).

One of the largest myths is that there really isn’t any regulation – Big Pharma owns the FDA (and other regulatory agencies) and does whatever it wants. But let’s look at the process of drug and vaccine development carefully, including how most drugs are investigated and brought to the market. Let’s try to separate the myths from the facts of pharmaceutical drug development.

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Coronavirus vaccine trials – updating current studies across the world

coronavirus vaccine trials

This article about coronavirus vaccine trials will has been substantially updated and published here. Please go there for the most up-to-date information about these vaccines.

Keeping up with COVID-19 vaccine candidates has gotten out of hand, so for brevity, I’ve created a separate list of coronavirus vaccine trials. The interest in clinical trials for a new COVID-19  vaccine is unprecedented, so I thought this might be the best way to keep loyal readers up-to-date.

Recently, the World Health Organization (WHO) has listed over 140 vaccine candidates, which is amazing, but it is way too difficult to tell which ones have any chance of actually becoming a real product.

Right now, there are 16 vaccine candidates in clinical trials – this article will analyze these coronavirus vaccine trials. Of course, this number changes from week-to-week, so who knows what it will be the next time I update this article!

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Coronavirus vaccine clinical trials – keeping up with everything out there

coronavirus vaccine clinical trials

This article about coronavirus vaccine clinical trials will be regularly updated as new clinical trials are registered or early results are published about an ongoing trial. Again, this article will focus on coronavirus clinical trials – treatments and diagnostic tests are outside of the scope of this article.

Keeping up with COVID-19 vaccine candidates has gotten out of hand, so for brevity, I’ve created a separate list of coronavirus vaccine clinical trials. The interest in clinical trials for a new vaccine is unprecedented, so I thought this might be the best way to keep loyal readers up-to-date.

Recently, the World Health Organization (WHO) has listed over 110 vaccine candidates, which is amazing, but it is way too difficult to tell which ones have any chance of actually becoming a real product.

Right now, there are numerous vaccine candidates in clinical trials – this article will analyze these coronavirus vaccine clinical trials.

Continue reading “Coronavirus vaccine clinical trials – keeping up with everything out there”

Evaluating coronavirus treatments like remdesivir – only science matters

coronavirus treatments

The ever-evolving world of fake coronavirus treatments, like Donald Trump’s push for hydroxychloroquine, has made it difficult for many people, even those who are well-informed about pharmaceutical research, to see when potential coronavirus treatments are overhyped.

Like my critique of the over-optimistic timelines for vaccines, we need to also carefully examine information about coronavirus treatments, especially antiviral drugs that are currently being rushed through development. 

For example, the antiviral, remdesivir from Gilead Sciences has been in clinical trials as a treatment (I think using the word “cure” might be an overstatement at this time) and has shown good results. Even Dr. Anthony Fauci, who has expressed valid skepticism of every claim from Trump about COVID-19 treatments, has stated that the results are “very optimistic.” In fact, the FDA may authorize the emergency use of remdesivir as a coronavirus treatment.

Let’s take a look at how we should evaluate various coronavirus treatments, using remdesivir as a model. Continue reading “Evaluating coronavirus treatments like remdesivir – only science matters”