Hydroxychloroquine ineffective for COVID-19, demon sperm, and zombies

hydroxychloroquine

Just when I thought I was out of the hydroxychloroquine pseudoscience, they pull me back in. And here we are, a group of fools is pushing it again. Sigh.

This all started because of an awful study from France published back in March of 2020. At that time, Donald Trump, desperate for a “win” against the coronavirus along with other non-scientists pushed hydroxychloroquine and azithromycin for coronavirus. Of course, me and many others like Orac, who has written several articles about it,  found the evidence that hydroxychloroquine, usually with the antibiotic azithromycin, had any effect on COVID-19 was very weak, even non-existent. 

And my mind hasn’t been changed in the meantime. And Orac is back calling hydroxychloroquine the “Black Knight,” a reference to a fictional character in the wonderful film, Monty Python and the Holy Grail. Oh, you never saw the movie? Well, I’ll let Orac tell that story:

In the film, King Arthur encounters him guarding a rather pathetic bridge and asks him to join his quest to seek the Holy Grail. The Black Knight refuses and then blocks Arthur’s passage with a menacing, “None shall pass.” The battle is joined, and Arthur, one by one, chops off all of the Black Knight’s limbs in a truly warped comedy sequence. After losing each limb, the Black Knight says things like, “‘Tis but a scratch” and “I’ve had worse.” Before his last leg is chopped off, the Black Knight proclaims (while hopping around), “I’m invincible,” to which Arthur retorts, “You’re a loony.” After losing his last limb, the Black Knight finally concedes, “All right, we’ll call it a draw.” Then, as Arthur crosses the bridge and rides off, the Black Knight yells, “Oh. Oh, I see. Running away, eh? You yellow bastards! Come back here and take what’s coming to ya! I’ll bite your legs off!”

In other words, this damn story about hydroxychloroquine keeps coming back despite having all of its limbs removed. “Tis but a scratch.” 

Now, I prefer zombie metaphors (and I believe so does Orac, but I have to give credit to him for the Monty Python reference), because, like many of the tropes we see in the anti-vaccine world, no matter how many times we kill this belief, it keeps coming back. In the world of zombies, one needs to destroy the brain. That’s why I try to present evidence!

Of course this time around, this claim includes demon sperms and alien DNA. I kid you not.

Continue reading “Hydroxychloroquine ineffective for COVID-19, demon sperm, and zombies”

Moderna vaccine update – are we too excited about it for COVID-19

moderna vaccine

If you have been paying attention to the news, you’ve probably seen reports of the Moderna coronavirus vaccine candidate that is getting a lot of people very excited. I’ve even seen so-called pro-vaccine people, who ostensibly should be following science, breathlessly cheer them on.

Recently, Moderna had released some results in a press release, and you know what I think about press releases. Unfortunately, many vaccine researchers stated that that data was not sufficient to draw any conclusions about the safety or effectiveness of the Moderna vaccine

However, the phase 1 clinical trial results have been published, and the hype has started again. We’ll take a brief look at those results below. 

I know that people want “hope,” as opposed to possibly endless cycles of bouncing between opening up and closing down everything in response to the pandemic, especially in the USA, where the coronavirus pandemic has just gotten worse.

But hope isn’t something that interests me at all. 

As anyone who reads my blog knows that the only thing that matters to me is published scientific evidence. And by published, I mean in a respected, peer-reviewed journal. Sure, I don’t need scientific evidence to support my belief that the New York Mets should be thrown out of baseball, because I hate the team – that’s just an opinion. It’s not based on evidence of any type.

On the other hand, when it comes to vaccines, we have built an amazing system of bringing the most effective and safest medical advances to humanity. Despite the misinformation and FUD of the anti-vaccine zealots, the safety and effectiveness of modern vaccines are settled science

I’m not willing to sacrifice that for a vaccine that may not be effective or safe. That’s why I want to take a very critical look at the Moderna vaccine. And I think there are some reasons to be very concerned about their vaccine, although there might be some reasons to be somewhat optimistic. Continue reading “Moderna vaccine update – are we too excited about it for COVID-19”

The coronavirus pandemic – just as bad for Trump supporting states

coronavirus pandemic

This article about how the coronavirus pandemic will affect conservative red states was written by a database expert who wishes to remain anonymous.

Among my more right-leaning Facebook friends, the attitude towards the coronavirus pandemic goes roughly like this: “The outbreak isn’t anywhere near as bad as the Liberal Media would have you believe. It’s almost entirely confined to sanctuary cities. Everyone should stop overreacting!”

For everyone else, this attitude seems delusional. But for people who live in right-wing communities, the “it’s not so bad” point of view is actually in line with observed reality. And the way that the media has been reporting on the outbreak actually exaggerates this effect. Continue reading “The coronavirus pandemic – just as bad for Trump supporting states”

Coronavirus vaccine warp speed – Scotty screaming at Captain Bonespurs

coronavirus vaccine warp speed

The coronavirus vaccine warp speed project from old Bonespurs, aka President Trump, is causing Scotty to yell, “Aye, the haggis is in the fire now for sure.” Operation Warp Speed is moving ahead at full power with not a single Starfleet Officer of note on board.

Not on board with the Star Trek metaphors?

Well, the coronavirus vaccine warp speed operation is President Bonespurs’, I mean Trump’s, new task force that will bring us a new vaccine in a matter of months. That’s not going to happen in any case, especially when the President Bonespurs, OK, Trump, didn’t add any of the country’s top vaccine researchers to the task force. 

Instead, he opted for industry hacks who have made some curious choices on the top vaccine candidates to support. Let’s take a look at the coronavirus vaccine warp speed directive. Continue reading “Coronavirus vaccine warp speed – Scotty screaming at Captain Bonespurs”

Hydroxychloroquine and azithromycin for coronavirus – UPDATED with new studies

hydroxychloroquine and azithromycin

Because of an awful study from France published on 20 March 2020, Donald Trump and other non-scientists pushed hydroxychloroquine and azithromycin for coronavirus. Of course, this old dinosaur and many others like Orac, who has written several articles about it,  found the evidence that hydroxychloroquine, usually with the antibiotic azithromycin, had any effect on COVID-19 was very weak. 

And now we have information that Donald Trump is taking hydroxychloroquine prophylactically (or maybe he has the disease and not saying it). This happened despite the lack of effectiveness, the lack of any data that it can be used as a prophylactic, and the strong evidence that it can cause serious harm.

And now, new observational studies now show that hydroxychloroquine and azithromycin had no positive effect on the course or outcomes from severe cases of COVID-19. Let’s take a look. 

Continue reading “Hydroxychloroquine and azithromycin for coronavirus – UPDATED with new studies”

Bill Gates vaccines – causing hate across science deniers everywhere

bill gates vaccines

Bill Gates vaccines are one of the biggest shibboleths of the anti-vaccine world.  Of course, he is one of the world’s leading sponsors of vaccine research along with healthcare (including vaccinations) to underdeveloped countries.

The Bill & Melinda Gates Foundation (BMGF), founded by Bill & Melinda Gates using their vast Microsoft wealth. I have always favored capitalism, and believe there is no particular moral code associated with accumulating wealth. It is, however, wonderful that they have decided to use their wealth to help humanity.

As strong supporters of vaccines, the Gates and their foundation have become one of the leading targets of the vaccine denialists who use a bunch of outright lies to attack his good works. Bill Gates and vaccines is a constant drumbeat from the anti-vaccine world.

Most of us know that Bill Gates did not invent these vaccines, but the attacks on him make it seem like he did.

These personal attacks remind me of Ernst’s Law, which states “If you are researching complementary and alternative medicine (CAM) and you are not hated by the CAM world, you’re not doing it right.” 

For vaccines, I guess we should create a corollary of the law, “if you are supporting the safety and efficacy of vaccinations for children, and you are not hated by vaccine denialists, you’re not doing it right.” I think I want to call this corollary “Offit’s Law,” named for Paul Offit, a tireless supporter of vaccines who has been the target of lies and hatred, or even “Gate’s Law.” 

So, let’s talk about Bill Gates vaccines. They are amusing. 

Continue reading “Bill Gates vaccines – causing hate across science deniers everywhere”

Coronavirus vaccine race – Operation Warp Speed could be a disaster

coronavirus vaccine race

Donald Trump has recently pushed “Operation Warp Speed” that will speed the coronavirus vaccine race so that we can have a new COVID-19 vaccine by January 2021. This is could end up being a disaster.

This is like the hundredth article I’ve posted on coronavirus vaccines. I just joked with someone that if I wrote an article that conclusively established that aluminum adjuvants in vaccines actually cured cancer, erectile dysfunction, and the inability to hit an inside curveball, the first 30 comments posted at the end of that article would ask, “yeah that’s nice to know, old dinosaur. But does it cure COVID-19?”

Even Dr. Anthony Fauci, whose facial expressions in response to whatever lie that Donald Trump is saying during his daily coronavirus campaign events are meme-worthy, has also said that we might see a vaccine within 12-18 months. Now, Dr. Fauci is a billion times smarter than I ever will be about immunology, infectious diseases, and baseball, but I have numerous reservations about this aggressive timeline. 

Maybe Dr. Fauci has some inside knowledge. Maybe he has seen some secret data only available only to him and Bill Gates. Maybe Trump has a gun pointed at him during these press briefings (really, campaign rallies). 

I don’t know the real answer, but a lot of vaccine experts who have spent their lifetime studying vaccines are very skeptical of this aggressive timeline for a new COVID-19 vaccine. I consider myself a pharmaceutical development expert, and I am unconvinced that this coronavirus vaccine race can be done safely. Continue reading “Coronavirus vaccine race – Operation Warp Speed could be a disaster”

Chloroquine for coronavirus, I mean the Trumpvirus – evidence is weak

chloroquine for coronavirus

I’m sure you’ve all heard that President Trump has pushed chloroquine for coronavirus treatment. He claims that there is good evidence supporting it, but if we actually look at that evidence, is there anything there?

Once again, here’s a spoiler alert – the evidence supporting chloroquine for coronavirus is extremely weak. And there seem to be some risks in taking it, so the actual risks may far outweigh the actual benefits.

Let’s take a look. Continue reading “Chloroquine for coronavirus, I mean the Trumpvirus – evidence is weak”

Coronavirus vaccines – massive list of vaccine candidates for COVID-19

coronavirus vaccines

Because of the ongoing COVID-19 pandemic, the interest in coronavirus vaccines has been quite high (to say the least). I have been keeping an updated list of vaccine candidates in another article, but it was becoming so cumbersome to update, and I wanted to make information clearer to read, I decided to completely rewrite it.

This article about coronavirus vaccines will also be regularly updated, so stay tuned. Continue reading “Coronavirus vaccines – massive list of vaccine candidates for COVID-19”

Coronavirus vaccine development – Donald Trump gets it all wrong again

coronavirus vaccine

Donald Trump’s ignorant comments about how the COVID-19 pandemic would be over by April makes people believe there is a coronavirus vaccine just around the corner. There isn’t. 

Of course, Trump is ignorant about the vast swaths of science from climate change to vaccines, so if he says anything about science, it should be immediately ignored.

Even if he claimed that the blue sky was caused refraction of light, I’d immediately go outside, check the color of the sky, then pull out a physics textbook to confirm what he said. I’m that skeptical of anything that comes out of his ignorant, anti-science mouth.

His claim that the epidemic will be over by April is in direct opposition to real scientists and experts at the CDC, WHO, and elsewhere, all of whom are extremely concerned about a coronavirus pandemic.

His comments, and questions across the internet, seem to imply that a coronavirus vaccine is around the corner, and we shouldn’t worry. Nothing could be further from the truth.

Let’s take a look at vaccine development, and I am going to especially focus on some of the technical challenges for a coronavirus vaccine. Just because we need some fact-based evidence so that pro- and anti-vaccine people understand what’s going on.

I’m assuming that most anti-vaxxers will publicly or secretly get the coronavirus vaccine. Just a guess, but maybe they’ll get information here first. Continue reading “Coronavirus vaccine development – Donald Trump gets it all wrong again”