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hpv vaccine

HPV vaccine fear mongering in an anti-vax book – a critical review

In 2018, “The HPV Vaccine On Trial: Seeking Justice For A Generation Betrayed”, was published. It was written by attorneys Kim Mack Rosenberg and Mary Holland, and Eileen Iorio described as a “health coach.”

As the title suggests, the book concluded that the HPV vaccine (from the first vaccine, licensed in the U.S. in 2006) was a betrayal, because it was unjustified, harmful, and with no health benefits. As the authors’ first chapter lays out, their opinion is in tension with statements from health authorities and cancer authorities worldwide – and goes against a large amount of data.

It is no exaggeration to say that the book is ill-founded, misleading, and anti-vaccine to the core. HPV vaccines have been especially signaled out by anti-vaccine activists since their creation. This book draws on anti-vaccine claims made over the years, including most of the older anti-vaccine tropes (claims, by the way, that are not always consistent with each other – for example, is the problem aluminum in vaccines, or a novel and different adjuvant?) and offering new (and ill-founded – see the discussion of chapter 8 below) ones.

To explain the problems with it, three of us divided the subjects in the book, and are reviewing it as a team. A review by Dan Kegel, who has an undergraduate degree in biology from Caltech and maintains a comprehensive site with the data on HPV and HPV vaccines, is found here. A review of the chapters on autoimmunity, aluminum, and a few more by John Kelly, a career biochemist, and molecular biologist and a survivor of HPV+ cancer, will be added later.

The book has four parts. I will not cover all of it, out of concern of making this review overly long. But I will raise some of the highlights. I am putting chapter 2 and 15 aside to address in my discussion below of the general use of anecdotes.Read More »HPV vaccine fear mongering in an anti-vax book – a critical review

preventing cervical cancer

Preventing cervical cancer – HPV vaccine uptake increases in Ireland

A few weeks ago I wrote an article about Emma Mhic Mhathúna was a 37-year-old Irish mother of five who died in October 2018 from cervical cancer – an easily diagnosed and treated cancer if discovered early. She died because of a pap smear scandal in Ireland that led her to receive a false negative on her two pap smear tests in 2016. As a result of this scandal, HPV vaccine uptake has increased for preventing cervical cancer.Read More »Preventing cervical cancer – HPV vaccine uptake increases in Ireland

HPV vaccine efficacy

HPV vaccine efficacy – another study shows long-term immunogenicity

As I’ve mentioned dozens of times, the anti-vaccine religion probably hates the HPV vaccine more than all others put together. They’ve invented numerous myths and tropes about the HPV vaccine, all without any foundation in science. One of these claims is that we don’t know anything about long-term HPV vaccine efficacy.

Of course, the HPV vaccine is a relatively new one, so long-term data requires us to wait for time to pass. Fortunately, we are accumulating a boatload of data that shows us that the long-term HPV vaccine efficacy is pretty strong.

And now, we have a powerful new study from Finland that shows that after 12 years post-vaccination, anti-HPV immunogenicity remains quite high. Let’s take a look.Read More »HPV vaccine efficacy – another study shows long-term immunogenicity

HPV vaccine adverse effects

HPV vaccine adverse effects and the European Medicines Agency

Despite the robust body of evidence supporting HPV vaccine safety and effectiveness, the European Medicines Agency (the European Union’s version of the US FDA) began a review of human papillomavirus (HPV) vaccines “to further clarify aspects of their safety profile,” although the agency also points out that this review did not “question that the benefits of HPV vaccines outweigh their risks.” In other words, the EMA examined the HPV vaccine adverse effects, real or imagined.

After a few months of investigation, the EMA came to a conclusion about HPV vaccine adverse effects – there were no major ones. Let’s take a look at this story.
Read More »HPV vaccine adverse effects and the European Medicines Agency

Cochrane HPV vaccine systematic review

Cochrane HPV vaccine systematic review – responses to anti-vax criticism

In May 2018, I wrote an article about a Cochrane HPV vaccine systematic review that provided solid evidence that the human papillomavirus (HPV) vaccine was safe and effective. I considered the review to be one of the seminal pieces that support the use of the cancer-preventing vaccine. Moreover, most scientists in the biomedical field consider Cochrane systematic reviews (see Note 1) as near the pinnacle of the hierarchy of biomedical research.

Then, in early August 2018, several anti-vaccine, and more particularly vehement anti-HPV vaccine, “researchers” at Cochrane Nordic, a branch of the Cochrane Collaboration, went on the attack against the HPV vaccine. They published a paper in BMJ Evidence Based Medicine that blasted the Cochrane HPV vaccine systematic review.

I thought that this critique was without merit. Moreover, nothing they wrote diminishes the quality of the original Cochrane HPV vaccine systematic review. Once again, that systematic review provided us with solid, high-quality support of the fact that the vaccine is, indeed, safe and effective.

Even though the anti-HPV vaccine group provided some apparently cogent criticisms, it was clear that they had an agenda. Well, there has been more backlash against the anti-vaccine “researchers” in a long post by a scientist who studies and analyzes systematic reviews. And Cochrane itself responded to the criticism. Let’s take a look. Read More »Cochrane HPV vaccine systematic review – responses to anti-vax criticism

primary ovarian insufficiency

Primary ovarian insufficiency unrelated to HPV vaccine – anti-vaxxers will move goalposts

Primary ovarian insufficiency (POI), previously known as premature ovarian failure, is one of those tropes pushed by the anti-vaccine religion – HPV vaccines cause POF. Although there is no robust epidemiological or clinical evidence of a link between the vaccine and primary ovarian insufficiency, the myth persists.

The overall safety of the HPV vaccine has been shown over and over again in multiple huge epidemiological studies published in top-tier, peer-reviewed journals. And in those studies, which include millions of patients, there have been no safety signals regarding primary ovarian insufficiency. Yet, the myth persists.

We’ve got a new large study, published in a top-ranked journal, that, once again, refutes this myth. Let’s take a look.Read More »Primary ovarian insufficiency unrelated to HPV vaccine – anti-vaxxers will move goalposts

Gardasil effectiveness

Gardasil effectiveness – yes, HPV vaccine does protect you against cancer

Although I have no poll numbers sitting in front of me, and certainly no scientific peer-reviewed research, I just have a feeling that if you scratch the surface of an anti-vaccine activist, you will find that if they could hate one vaccine, it would be Gardasil. And one of the arguments will be all about Gardasil effectiveness – they claim it doesn’t actually prevent cancer.

When you couple their false claims about the dangers of the vaccine with the claims about the lack of Gardasil effectiveness, you’d probably agree with the anti-vaccine crowd. Despite these false claims, HPV vaccine uptake has slowly grown in the US and other countries.

I’ve written nearly 200 articles about the HPV cancer-preventing vaccine, but most of those are focused on debunking myths and confirming the safety of the vaccine. I’m going to focus on a quick primer about Gardasil effectiveness in preventing cancer. Stay tuned for some interesting science.Read More »Gardasil effectiveness – yes, HPV vaccine does protect you against cancer

cervical cancer rate

Cervical cancer rate declines after introduction of HPV vaccine – new evidence

One of the misinformed tropes of the anti-vaccine world is that there is no evidence that the human papillomavirus (HPV) vaccine actually reduces cancer rates. Given that the vaccine was only introduced in the last 10 years, it would take time for researchers to study this issue. But now, we have more evidence that the cervical cancer rate declined after the introduction of the HPV vaccine in the USA.

We have robust evidence that the HPV vaccine actually stops HPV infections, which are linked to several types of cancer. Over the past few years, a number of published articles have provided us with powerful evidence that the HPV vaccine is significantly reducing the cervical cancer rate.

Although there is a myth that the HPV vaccine is just to prevent cervical cancer, I expect, over the next few years, there will be new research that shows reductions in other cancers, in both women and men, as a result of the introduction of the vaccine. Moreover, the effect of the vaccine on males may take longer since the vaccine was recommended for males only a few years after it was introduced.

This year, a solid systematic review, the most powerful research in the hierarchy of biomedical science, along with other studies, have been published that provide strong evidence that the HPV vaccine reduces the cervical cancer rate. Now we have a new study to add to the body of science supporting the effectiveness in preventing cancers of the HPV vaccine.Read More »Cervical cancer rate declines after introduction of HPV vaccine – new evidence