Cervical cancer rate declines after introduction of HPV vaccine – new evidence

cervical cancer rate

One of the misinformed tropes of the anti-vaccine world is that there is no evidence that the human papillomavirus (HPV) vaccine actually reduces cancer rates. Given that the vaccine was only introduced in the last 10 years, it would take time for researchers to study this issue. But now, we have more evidence that the cervical cancer rate declined after the introduction of the HPV vaccine in the USA.

We have robust evidence that the HPV vaccine actually stops HPV infections, which are linked to several types of cancer. Over the past few years, a number of published articles have provided us with powerful evidence that the HPV vaccine is significantly reducing the cervical cancer rate.

Although there is a myth that the HPV vaccine is just to prevent cervical cancer, I expect, over the next few years, there will be new research that shows reductions in other cancers, in both women and men, as a result of the introduction of the vaccine. Moreover, the effect of the vaccine on males may take longer since the vaccine was recommended for males only a few years after it was introduced.

This year, a solid systematic review, the most powerful research in the hierarchy of biomedical science, along with other studies, have been published that provide strong evidence that the HPV vaccine reduces the cervical cancer rate. Now we have a new study to add to the body of science supporting the effectiveness in preventing cancers of the HPV vaccine. Continue reading “Cervical cancer rate declines after introduction of HPV vaccine – new evidence”

HPV vaccine systematic review – anti-vaxxers and Cochrane

HPV vaccine systematic review

Back in May 2018, I wrote an analysis of a new HPV vaccine systematic review that clearly showed that not only was the HPV vaccine very safe, but it was also effective in significantly reducing the risks of cervical cancer. This was powerful and robust evidence that the HPV vaccine is one of the best tools in reducing HPV-related cancers. And that the vaccine is extremely safe, possibly the safest of all the very safe vaccines on the market.

For those who aren’t science nerds like me, you should know systematic reviews are at the pinnacle of the hierarchy of biomedical research. These type of reviews are one of the foundations of science-based medicine (SBM).

The idea of SBM is …to answer the question “what works?” we must give more importance to our cumulative scientific knowledge from all relevant disciplines.

Now I’ve said that systematic reviews are not perfect. For example, the Cochrane Database is considered one of the premier organizations that perform systematic and meta-reviews in the biomedical sciences. If I am looking to determine if there is evidence supporting a medical claim, I look there first. As a scientist, I don’t take their conclusions at face value – for example, they have made egregious errors in systematic reviews of acupuncture quackery in the past. Like all scientific literature, one must examine a systematic review (whether published in Cochrane or any other journal) with a critical eye. Is there bias in including or excluding data? Do they overstate the conclusion? Do they rely upon unusual or bad statistical analyses?

Recently, one Cochrane group has attacked the aforementioned HPV vaccine systematic review, written by another Cochrane group. Time to take a look at that. Continue reading “HPV vaccine systematic review – anti-vaxxers and Cochrane”

Japan banned Gardasil – another ridiculous anti-vaccine myth

Japan Banned Gardasil

One of the most popular zombie memes and tropes of the anti-vaccine movement is that Japan banned Gardasil, the HPV vaccine. And like most of those zombie memes and tropes, the facts are a lot different than the anti-vaccine claims. Per usual.

Although I don’t quite understand the reasoning, the anti-vaccine religion absolutely hates Gardasil, possibly more than any other vaccine. These zealots maintain that the HPV vaccines cause all kinds of harm to teens and young adults. Yet, there are literally mountains of data derived from numerous huge epidemiological studies that the Gardasil cancer-preventing vaccine is one of the safest vaccines on the market.

So if you really want to prevent cancer, one of the best ways available to you is getting the HPV vaccine. The idea is so simple, yet is clouded by the myths about HPV vaccines – one of the most popular, of course, is that Japan banned Gardasil. Let’s examine this fable with a critical and skeptical eye.

Spoiler alert – Japan did no such thing.

Continue reading “Japan banned Gardasil – another ridiculous anti-vaccine myth”

Peter Doshi, anti-vaccine false authority, back again to push fake science

Peter Doshi

The bloviating Peter Doshi, who loves all things anti-vaccine, filed a lawsuit against Health Canada, essentially, the Ministry of Health for the country and the ministry that regulates medications and vaccines for Canada, to retrieve all of the clinical trial data for HPV vaccines that was used to get approval for the vaccines in the country (see Note 1). He recently won that lawsuit, and, unless Health Canada appeals the ruling, so we can assume he will receive mountains of data to “analyze.”

According to an article in the CBC, the ruling gives Doshi access to clinical trial data submitted to Health Canada by the manufacturers of HPV vaccines, Gardasil, Gardasil9, and Cervarix, and of anti-viral flu medications. Doshi wants to do a “systematic review” of the findings, although I don’t think that’s what a systematic review is, we’ll discuss that below. Health Canada argued that the data was confidential, and they would only hand over the data if he signed a non-disclosure agreement. Doshi refused, and he prevailed in the lawsuit.

You may have read all of this and wondered who is this Peter Doshi and why do I dislike him so. Well, most of you know of Doshi. And then you wonder why I care at all that he gets this data. I actually don’t care, but I should talk about it anyway.

So, let’s talk about the false authority, Peter Doshi, and why it matters or not that he gets this data. Spoiler alert – it doesn’t matter, but we should be prepared. Continue reading “Peter Doshi, anti-vaccine false authority, back again to push fake science”

Anti-vaccine website gets everything wrong about HPV vaccine – shocking news

anti-vaccine website

I know that I’m going to make my loyal readers all have strokes by telling all of you that an anti-vaccine website gets all the facts wrong about the HPV vaccine. I know you just can’t imagine that any anti-vaccine website is filled with scientific facts. I hate to be the one to break this sad news, but I doubt that most of them can spell vaccine, let alone present scientific facts.

An anti-vaccine website, that is an unknown to me, dropped this breathless headline late last month – “Pfizer Vice President Blows Whistle – ‘The Gardasil Vaccine is Deadly.‘” Oh no, I’ve been wrong. The dozens of high quality clinical and epidemiological studies that have firmly established the safety of the vaccine are useless because a Pfizer VP says so.

Because I’m a corporate shill, if a Pfizer VP tells me I’m wrong, I must be wrong. Let’s close down shop and move on to some other pursuit like analyzing the World Cup. Apparently, I know more about the World Cup than I do about Gardasil. Continue reading “Anti-vaccine website gets everything wrong about HPV vaccine – shocking news”

Gayle DeLong tries to correct her anti-vaccine article by blogging

Gayle DeLong

A few days ago, I wrote about a terrible, laughable anti-HPV vaccine article by Gayle DeLong, a tenured Associate Professor in the Department of Economics and Finance in the Zicklin School of Business, Baruch College/City University of New York. She has zero backgrounds, experience, knowledge, education or credibility in vaccine science.

Her appalling article tried to convince the reader that the human papillomavirus (HPV) vaccine caused a decrease in fertility. If this were a real article, I’d be appalled, but it was a garbage article. It failed basic scientific statistical analysis like accounting for confounding data. Furthermore, Gayle DeLong provided no convincing biologically plausible mechanism describing how the HPV vaccine could affect pregnancy rates. And her references were ridiculous – she cited Mark and David Geier, who can charitably be called charlatans who attempted to “treat” autistic children with a horrific and unethical procedure. And she actually mentioned Mark Geier in her acknowledgments.

Furthermore, she ignored the vast body of evidence, published by real scientists, not an expert in international finance, in real journals that the HPV vaccine is demonstrably safe. And in those huge studies, some with millions of patients, there was no detectable difference in fertility rates between vaccinated and unvaccinated individuals. This issue only exists in the mind of Gayle DeLong and other anti-vaccine activists.

I’ve read a bunch of anti-vaccine papers in my time, but this one may be one of the worst. All anti-vaccine papers are all bad, so it’s just a rank ordering of these papers in a sewer. Continue reading “Gayle DeLong tries to correct her anti-vaccine article by blogging”

HPV vaccine could prevent 41,000 cancers a year – Gardasil works

HPV vaccine

I do repeat myself repeatedly, I admit, especially about cancer. There are really only a handful of ways to lower your risk of cancer – stop smoking, stay out of the sun, eat a “healthy” diet, keep a healthy weight, don’t drink alcohol, and a few other things. One of those few science-based methods to stave off cancer is getting vaccinated against cancer-causing viruses. The HPV vaccine and hepatitis B vaccine (see Note 1) are some of the most powerful tools in cancer prevention.

The Centers for Disease Control and Prevention (CDC) have published a detailed report of HPV-related cancers in the USA, and it states that there are over 41,000 HPV-related cancers diagnosed every year. The National Cancer Institute categorizes “common cancers” as those with over 40,000 new cases a year – if we could lump all of these HPV-related cancers into one group, it would be considered a common cancer, contradicting the anti-vaccine memes that HPV isn’t that dangerous.

And the HPV vaccine could prevent most of those cancers by blocking the HPV types that cause those cancers. Continue reading “HPV vaccine could prevent 41,000 cancers a year – Gardasil works”

Diane Harper, star of anti-vaccine memes, supports HPV vaccines

Diane Harper

If you have any interest in HPV vaccines, you’ve probably heard about Diane Harper, who the anti-vaccine religion claims was a “lead Gardasil researcher” who came out against the vaccine. Many of us were never convinced that she was really anti-vaccine, although she seemed to have vacillating views on the HPV vaccine depending on a variety of random factors, including who was feting her at any particular point in time.

Dr. Harper was a frustrating character in the conversations about the HPV vaccine. Although some (but certainly not all) of her comments about the vaccine could be construed as an anti-HPV vaccine, her publications, and many other public comments, seemed to clearly show that she was a supporter of the vaccine.

A few writers in the scientific skeptic blogosphere have contacted her, either in person or through interviews, and most have come away with the impression that she was solidly in support of the vaccine. However, and I have no evidence of this whatsoever, she always seemed to be biased against Gardasil, manufactured by Merck, so maybe she had some personal vendetta. We will probably never know, I suppose.

But a recent announcement should put an end to the Diane Harper anti-Gardasil meme – well I’m more cynical than that, I know the vaccine denier mob will keep bringing it back like a zombie. So, let’s take a look at Dr. Harper and her announcement. No one should be surprised. Continue reading “Diane Harper, star of anti-vaccine memes, supports HPV vaccines”

HPV vaccine affects pregnancy rate – laughable anti-vaxxer study

hpv vaccine affects pregnancy

I thought I had read it all, but here comes one out of recesses of the anti-vaccine mind – where logic and science disappear into a black hole. This time, an economist, with absolutely no background in science, writes a lame article that claims that the HPV vaccine affects pregnancy rate. Somehow, because of reasons, unknown to modern science.

The anti-vaccine religion definitely hates the HPV vaccine more than any other one out there. They invent more lies about it while ignoring the overwhelming scientific consensus about the vaccine’s safety and effectiveness. But relying upon facts is generally not something found in the anti-vaccine wheelhouse.

Of course, the false claims about the HPV vaccine often rely upon pseudoscience produced by anti-vaccine shills like the oft-retracted Shaw and Tomljenovic, the infamous Lyons-Weiler, and the preposterous Shoenfeld. Because the anti-vaxxers lack any evidence to support their dislike of the HPV vaccine, they require the appeal to false authority to claim that these discredited pseudoscientists’ work is somehow more important than all of the body evidence, from real, respected scientists, that supports HPV vaccine safety and effectiveness.

So, let’s take a look at this new study from a non-scientist claiming that the HPV vaccine affects pregnancy rates. I almost thought about ignoring it, but it’s just too funny. Continue reading “HPV vaccine affects pregnancy rate – laughable anti-vaxxer study”

Autoimmune diseases unrelated to HPV vaccine – new Canadian study

autoimmune diseases

There are so many outlandish and unsupported claims about the HPV vaccine, it’s difficult to keep up with them all. One of the most outrageous lies about the HPV vaccine is that it causes autoimmune diseases, despite the robust epidemiological or clinical evidence that firmly establishes the safety of the HPV vaccine, especially with respect to autoimmune diseases.

Autoimmune diseases are conditions where the immune system has an abnormal response to normal cells in the body. Celiac disease, type 1 diabetes mellitus, multiple sclerosis, and many other conditions are as a result of an autoimmune disorder. We don’t know what causes the autoimmunity, but there is almost no biological plausibility that any vaccine could induce the disease.

Despite the lack of a reasonable biological mechanism leading from the HPV vaccine to any of the multitudes of autoimmune diseases, the anti-vaccine forces continue to try to establish a link. For example, Yehuda Shoenfeld has pushed a ridiculed hypothesis that the vaccine causes something he calls autoimmune syndrome induced by adjuvants (ASIA). Not a single respected scientist buys into ASIA, and Shoenfeld has presented no vigorous clinical or epidemiological evidence supporting its existence.

Not to pile onto the anti-vaccine tropes about the vaccine, but a large, and new, Canadian study has once again shown us that there are no links between the HPV vaccine and autoimmune diseases. This adds to the body of evidence that, for real science, reinforces the conclusion that the HPV vaccine is an incredibly safe vaccine. Continue reading “Autoimmune diseases unrelated to HPV vaccine – new Canadian study”