Gardasil facts – debunking myths about HPV vaccine safety and efficacy

Gardasil safety and efficacy

The HPV cancer-preventing vaccine, especially Gardasil (or Silgard, depending on market), has been targeted by the anti-vaccine religion more than just about any other vaccine being used these days. So many people tell me that they give their children all the vaccines, but refuse to give them the HPV vaccine based on rumor and innuendo on the internet. This article provides all the posts I’ve written about Gardasil safety and efficacy.

As many regular readers know, I focus on just a few topics in medicine, with my two favorites being vaccines and cancer – of course, the Gardasil cancer-preventing vaccine combines my two favorite topics. Here’s one thing that has become clear to me – there are no magical cancer prevention schemes. You are not going to prevent any of the 200 different cancers by drinking a banana-kale-quinoa smoothie every day. The best ways to prevent cancer are to quit smoking, stay out of the sun, keep active and thin, get your cancer-preventing vaccines, and following just a few more recommendations.

The benefits of the vaccine are often overlooked as a result of two possible factors – first, there’s a disconnect between personal activities today and cancer that could be diagnosed 20-30 years from now; and second, people think that there are significant dangers from the vaccine which are promulgated by the anti-vaccine religion.

It’s frustrating and difficult to explain Gardasil safety and efficacy as a result of the myths about safety and long-term efficacy of the vaccine. That’s why I have written nearly 200 articles about Gardasil safety and efficacy, along with debunking some ridiculous myths about the cancer-preventing vaccine. This article serves to be a quick source with links to most of those 200 articles.

And if you read nothing else in this review of Gardasil, read the section entitled “Gardasil safety and effectiveness – a quick primer” – that will link you to two quick to read articles that summarize the best evidence in support of the vaccine’s safety and effectiveness.

Continue reading “Gardasil facts – debunking myths about HPV vaccine safety and efficacy”

FDA approved Gardasil vaccine for 45 year olds – preventing more cancers

FDA approved Gardasil

Sometimes we get good news about vaccines, and this week, we definitely got good news. The FDA approved Gardasil for 27 through 45-year-olds, greatly expanding the age indications for the vaccine. Consequently, more people are protected against dangerous and deadly cancers.

I always thought that the age cutoff, 26 years, was rather arbitrary and that the vaccine would be safe and effective for a 27-year-old as much as it is for a 26-year-old. The FDA can be very conservative with indications for all medications, including vaccines, so they probably awaited more data before moving the approved age for the vaccine up to 45 years. But it’s better late than never that the FDA approved Gardasil for “older” individuals.

The importance of the vaccine is because genital, anal, and oral human papillomavirus (HPV) infections are the most common sexually transmitted infections (STI) in the USA.  HPV is generally transmitted from personal contact during vaginal, anal or oral sex.

HPV is believed to cause nearly 5% of all new cancers across the world, making it almost as dangerous as tobacco in that respect. According to the CDC, roughly 79 million Americans are infected with HPV – approximately 14 million Americans contract a new HPV every year. Most individuals don’t even know they have the infection until the onset of cancer. The CDC also states that over 43,000 HPV-related cancers are diagnosed in the USA every year. It may be several times that amount worldwide.

Although the early symptoms of HPV infections aren’t serious and many HPV infections resolve themselves without long-term harm, HPV infections are causally linked to many types of cancers in men and women. According to current medical research, here are some of the cancers that are linked to HPV:

In addition, there is some evidence that HPV infections are causally linked to skin and prostate cancers. The link to skin cancer is still preliminary, but there is much stronger evidence that HPV is linked to many prostate cancers.

Merck manufactures Gardasil, along with Gardasil 9, approved by the FDA in 2014, which a 9-valent vaccine, protecting against HPV Types 6, 11, 16, 18, 31, 33, 45, 52, and 58. It targets the four HPV strains found in the quadrivalent version, along with five additional ones that are linked to cervical and other HPV-related cancers. Both versions of Gardasil are prophylactic, meant to be given to females or males before they become exposed to possible HPV infection through intimate contact.

Currently, in the United States, the Advisory Committee on Immunization Practices (ACIP) recommends that preteen girls and boys aged 11 or 12 are vaccinated against HPV.

In the press release, Peter Marks, MD, PhD, director of the FDA’s Center for Biologics Evaluation and Research, said:

Today’s approval represents an important opportunity to help prevent HPV-related diseases and cancers in a broader age range.

The Centers for Disease Control and Prevention [CDC] has stated that HPV vaccination prior to becoming infected with the HPV types covered by the vaccine has the potential to prevent more than 90% of these cancers from ever developing.

Also, the FDA stated:

Effectiveness of Gardasil 9 in men 27 through 45 years of age is inferred from the data described above in women 27 through 45 years of age, as well as efficacy data from Gardasil in younger men (16 through 26 years of age) and immunogenicity data from a clinical trial in which 150 men, 27 through 45 years of age, received a 3-dose regimen of Gardasil over 6 months.

I know that some may claim that anyone who is 45 years old may have already contracted an infection from one or two HPV types. However, since the current Gardasil9 protects against 9 different HPV types, it’s very possible that the vaccine can provide protection against other HPV types.

As I have written over 100 times, Gardasil is demonstrably effective and incredibly safe. And now that the FDA approved Gardasil for up to 45-year-old men and women means more people can be protected against deadly cancers.

Why shouldn’t anyone up to the age of 45 get this vaccine? Of course, I think that 45 is still arbitrary, and if you can convince your healthcare plan (most will agree) or can afford the vaccine, I don’t think it matters if you’re 50, 55 or 60, especially if you’re sexually active, to get the HPV vaccine.



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HPV vaccine adverse effects and the European Medicines Agency

HPV vaccine adverse effects

Despite the robust body of evidence supporting HPV vaccine safety and effectiveness, the European Medicines Agency (the European Union’s version of the US FDA) began a review of human papillomavirus (HPV) vaccines “to further clarify aspects of their safety profile,” although the agency also points out that this review did not “question that the benefits of HPV vaccines outweigh their risks.” In other words, the EMA examined the HPV vaccine adverse effects, real or imagined.

After a few months of investigation, the EMA came to a conclusion about HPV vaccine adverse effects – there were no major ones. Let’s take a look at this story.
Continue reading “HPV vaccine adverse effects and the European Medicines Agency”

43,000 HPV-associated cancers annually – HPV vaccine can prevent most

HPV-associated cancers

As I’ve written before, there are just a handful of ways to reduce your risk of cancer. Don’t smoke. Stay out of the sun. Keep a healthy weight. Don’t drink alcohol. And get vaccinated with the HPV vaccine to prevent HPV-associated cancers (see Note 1).

Too many people who discuss the HPV vaccine, especially among the anti-vaccine religion, tend to focus on HPV-related cervical cancer. But HPV is linked to several dangerous and deadly cancers, and a new report examines the details of those cancers.  Continue reading “43,000 HPV-associated cancers annually – HPV vaccine can prevent most”

Japan banned Gardasil – another ridiculous anti-vaccine myth

Japan Banned Gardasil

One of the most popular zombie memes and tropes of the anti-vaccine movement is that Japan banned Gardasil, the HPV vaccine. And like most of those zombie memes and tropes, the facts are a lot different than the anti-vaccine claims. Per usual.

Although I don’t quite understand the reasoning, the anti-vaccine religion absolutely hates Gardasil, possibly more than any other vaccine. These zealots maintain that the HPV vaccines cause all kinds of harm to teens and young adults. Yet, there are literally mountains of data derived from numerous huge epidemiological studies that the Gardasil cancer-preventing vaccine is one of the safest vaccines on the market.

So if you really want to prevent cancer, one of the best ways available to you is getting the HPV vaccine. The idea is so simple, yet is clouded by the myths about HPV vaccines – one of the most popular, of course, is that Japan banned Gardasil. Let’s examine this fable with a critical and skeptical eye.

Spoiler alert – Japan did no such thing.

Continue reading “Japan banned Gardasil – another ridiculous anti-vaccine myth”

Penis transplant – the HPV vaccine is a way to avoid it

penis transplant in South Africa.

Sometimes, the people who hate the HPV vaccine dismiss the awful consequences of an HPV infection as if they are unimportant. HPV is linked to several deadly and disfiguring cancers. Maybe you heard the story of a man who received a penis transplant. And it has a lot to do with the HPV vaccine.

Setting aside all of the jokes and uncomfortable thoughts, this procedure could be an important medical procedure for men who have lost their penis through injury or disease. For example, veterans of wars are at grave risk to injuries that cause the loss of their penis. Mines and IEDs in war are particularly damaging in ways that can cause permanent trauma to a soldier’s penis. Having a method to replace it, like a transplant, can be a great way to improve the soldier’s mental health and personal self-image.

However, this story is about a 64-year-old Boston man, Thomas Manning, who had to have his penis surgically removed in 2012 because of HPV-related penile cancer, a rare and devastating disease. In 2016, he had an innovative penis transplant to replace his cancer. Continue reading “Penis transplant – the HPV vaccine is a way to avoid it”

Reducing HPV-related cancers with HPV vaccine – a study in Norway

hpv-related cancers

Cancer prevention is a big business on the internet. A quick search will find someone hawking supplements or the new quinoa blueberry smoothie to prevent cancer. But from a scientific perspective, there’s really only a handful of ways to substantially reduce your risk of cancers. One of that handful of methods is to get the HPV vaccine that will reduce your risk of contracting HPV-related cancers.

Recently, a study examined the long-term trends of HPV-related cancers in Norway and estimated the number of cancer cases that could be prevented by HPV vaccines. This adds to the mountain of evidence that the HPV vaccine ought to be known as the “cancer-preventing HPV vaccine.” OK, I’m not good at naming vaccines.

Let’s talk a little about HPV, then tackle this new research. Continue reading “Reducing HPV-related cancers with HPV vaccine – a study in Norway”

HPV vaccine and multiple sclerosis – 2 million doses show no link

hpv vaccine and multiple sclerosis

We keep reading false claims about Gardasil, like some link between the HPV vaccine and multiple sclerosis. It is important that we, those who support vaccines, keep focusing on the huge studies that support the facts about the safety of the vaccine.

Despite the established effectiveness of the HPV vaccine in preventing the HPV infection and subsequent HPV-related cancers, the internet rumors about the dangers of the vaccine sometimes feel like it wins the day.

Remember, despite what you read on pseudoscience website or from anecdotes on the internet, there are really only a few ways to prevent cancer. Don’t smoke. Don’t drink alcohol. Stay out of the sun. Keep a very healthy (read low) weight. And get your HPV (and hepatitis B) vaccines.

This post is going to discuss a seminal article about the safety of vaccines – an epidemiological study of over 2 million young women to determine the incidence of neurological disorders in HPV-vaccinated vs. unvaccinated groups. This powerful study tells us one thing – that the continued claims about Gardasil causing all these weird neurological issues is not supported by unbiased, scientifically analyzed, peer-reviewed articles. And head’s up, there appears to be no evidence supporting a link between the HPV vaccine and multiple sclerosis.

Let’s discuss.

Continue reading “HPV vaccine and multiple sclerosis – 2 million doses show no link”

Gardasil safety supported by a large study of 200 thousand young women

Gardasil safety

I regularly write about Gardasil safety and effectiveness, because I consider the HPV vaccine one of top 100 greatest medical inventions over the past century or so. We have so few ways to prevent cancer, despite the nonsense pushed by pseudoscientists like the brainless Food Babe. And one of the best ways to prevent cancer is getting the HPV vaccine to prevent HPV related cancers.

I originally wrote this article around 5 years ago, but it needed updating on several issues since things have changed on this website. But why do I care about maintaining a 5-year-old article about Gardasil safety? Because this is one of the seminal articles about Gardasil safety, one that is important to anyone’s understanding of the subject.

Let’s get into it. Continue reading “Gardasil safety supported by a large study of 200 thousand young women”

HPV vaccine efficacy in reducing HPV infections – Australia experience

HPV vaccine efficacy

In my 100 or more articles about the HPV vaccine, I spend as many words discussing HPV vaccine efficacy as I do about adverse events (which are extremely rare, despite the pseudoscientific claims of the anti-vaccine world). I keep reading comments and claims from the anti-vaccine religion that there is no “proof” that the HPV vaccine prevents infections and certainly no “proof” that it prevents cancer.

Well, a new article has been published that that describes how far HPV infection rates have dropped in Australia nine years after the implementation of HPV vaccination. Spoiler alert – the infection rate went way down, even though vaccine coverage is far from 100%.

Let’s take a look at this article, which provides us with more evidence in supporting the use of the HPV vaccine. HPV vaccine efficacy is corroborated by this new data. Continue reading “HPV vaccine efficacy in reducing HPV infections – Australia experience”