Pfizer and Moderna vaccines for COVID-19 – differences and similarities

If you are an American, you probably could not avoid noticing the news that the Pfizer and Moderna vaccines for COVID-19 have shown >90% effectiveness in preventing the disease over the short-term. And both companies would probably be seeking an Emergency Use Authorization (EUA) in the USA for use of their vaccines in groups who are most in need of protection from COVID-19. 

Even though I’ve discussed the positive and negative points about the Pfizer and Moderna COVID-19 vaccines, I think it’s important to highlight the similarities and differences between the two vaccines. Also, please note that these vaccines probably will be released first in the USA, especially Moderna who received support from the Federal Government through Operation Warp Speed (Pfizer opted out of it). There are several other vaccines in phase 3 clinical trials that could be seeking a EUA sometime in the near future in the USA and Europe. 

COVID-19 vaccine candidates in phase 3 clinical trials – the official list

Moreover, there are over 200 COVID-19 vaccine candidates in development, with dozens in phase 1 and phase 2 clinical trials. By early 2022, we could be comparing 10 or 15 vaccines that might be entering the market. 

But this article is just going to focus on the Pfizer and Moderna COVID-19 vaccines. I’m going to hit the key similarities and differences between the two vaccines. I may conclude with my opinion on which one will be successful, but we might not know for years which of all of these vaccines are the “best.”

Continue reading “Pfizer and Moderna vaccines for COVID-19 – differences and similarities”

COVID-19 vaccine candidates in phase 3 clinical trials – the official list

COVID-19 vaccine candidates

Keeping up with COVID-19 vaccine candidates in clinical trials has gotten out of hand, so keeping up with these clinical trials have become almost impossible. For brevity, I have made the editorial decision to update this list to include just those vaccines in phase 3 clinical trials, which means that they are within the final stages of clinical assessment. 

Recently, the World Health Organization (WHO) has listed over 200 COVID19 vaccine candidates, which is amazing, but it is still too difficult to tell which ones will be successful or not without reviewing the actual data. Just because it’s in a phase 3 trial does not mean it will work.

Right now, there are nearly 50 COVID-19 vaccine candidates in phase 1, 2, or 3 clinical trials – this article will only focus on those in phase 3. 

Continue reading “COVID-19 vaccine candidates in phase 3 clinical trials – the official list”

Pfizer COVID-19 vaccine news – should we pump the brakes just a bit?

pfizer COVID-19 vaccine

Recently, we saw a lot of news about the Pfizer COVID-19 vaccine –  it seemed to show about a 90% effectiveness in preventing the disease. This is potentially good news in preventing the spread of this disease because alternatives like herd immunity is a disastrous form of genocide.

But, what does this news actually mean? Does it imply that the world is saved, and soon we can eschew masks and social distancing? Does that mean the pandemic will come to an end?

We need to know if the COVID-19 vaccine actually does what Pfizer claims. We need to know if it is safe. And we need to know when the vast majority of people can receive the vaccine. When we know all of that, we can then see the light at the end of the tunnel for this deadly pandemic.

Let’s take a skeptical look at the Pfizer COVID-19 vaccine along with what it may mean to the world. I’m writing this in the form of several questions that I have with the answers as I know them. 

Continue reading “Pfizer COVID-19 vaccine news – should we pump the brakes just a bit?”

Moderna vaccine update – are we too excited about it for COVID-19

moderna vaccine

If you have been paying attention to the news, you’ve probably seen reports of the Moderna coronavirus vaccine candidate that is getting a lot of people very excited. I’ve even seen so-called pro-vaccine people, who ostensibly should be following science, breathlessly cheer them on.

Recently, Moderna had released some results in a press release, and you know what I think about press releases. Unfortunately, many vaccine researchers stated that that data was not sufficient to draw any conclusions about the safety or effectiveness of the Moderna vaccine

However, the phase 1 clinical trial results have been published, and the hype has started again. We’ll take a brief look at those results below. 

I know that people want “hope,” as opposed to possibly endless cycles of bouncing between opening up and closing down everything in response to the pandemic, especially in the USA, where the coronavirus pandemic has just gotten worse.

But hope isn’t something that interests me at all. 

As anyone who reads my blog knows that the only thing that matters to me is published scientific evidence. And by published, I mean in a respected, peer-reviewed journal. Sure, I don’t need scientific evidence to support my belief that the New York Mets should be thrown out of baseball, because I hate the team – that’s just an opinion. It’s not based on evidence of any type.

On the other hand, when it comes to vaccines, we have built an amazing system of bringing the most effective and safest medical advances to humanity. Despite the misinformation and FUD of the anti-vaccine zealots, the safety and effectiveness of modern vaccines are settled science

I’m not willing to sacrifice that for a vaccine that may not be effective or safe. That’s why I want to take a very critical look at the Moderna vaccine. And I think there are some reasons to be very concerned about their vaccine, although there might be some reasons to be somewhat optimistic. Continue reading “Moderna vaccine update – are we too excited about it for COVID-19”

Moderna coronavirus vaccine – tempering the breathless pharma hype

moderna coronavirus vaccine

This article about the Moderna coronavirus vaccine candidate has been updated and published here

If you have been paying attention to the news, you’ve probably seen reports of the Moderna coronavirus vaccine candidate that is getting everyone all excited about a vaccine “real soon now.” I’ve even seen so-called pro-vaccine people, who ostensibly should be following science, breathlessly cheer them on.

Instead of waiting for actually published scientific results, so that we can see if the Moderna coronavirus vaccine actually shows any safety or effectiveness, people are demanding it “right now.” If this were someone pushing an anti-malarial drug as a “cure” for COVID-19, we’d be relentlessly mocking them. And we do.

People want “hope,” as opposed to possibly endless cycles of bouncing between opening up and closing down in response to the pandemic. But hope isn’t a part of the realm of scientific research – that’s best left to those who believe in the Age of Aquarius. 

As anyone who reads my blog knows that the only thing that matters to me is published scientific evidence. And by published, I mean in a respected, peer-reviewed journal. Sure, I don’t need scientific evidence to support my belief that the New York Mets should be thrown out of baseball, because I hate the team – that’s just an opinion.

But when it comes to vaccines, we have built an amazing system of bringing the most effective and safest medical advances to humanity. Despite the misinformation and FUD of the anti-vaccine zealots, the safety and effectiveness of modern vaccines are settled science

I’m not willing to sacrifice that for a vaccine that may not be effective or safe. That’s why I want to take a very critical look at the Moderna coronavirus vaccine. And I think there are more reasons to be skeptical than not. Continue reading “Moderna coronavirus vaccine – tempering the breathless pharma hype”