Vaccine development process in the world of a coronavirus pandemic

Back before the world of the COVID-19 pandemic, the vaccine development process took a long time. Despite the nonsensical claims of the anti-vaccine zealots, the vaccine development process was robust and thorough. The safety and effectiveness of all of the pre-pandemic vaccines are settled science (read the article before you jump up and down screaming about “settled science”).  

However, the world of the coronavirus pandemic means that if we can save a few months or even years off the development timeline on a new COVID-19 vaccine, it could save hundreds of thousands of lives. This does not mean those political agendas like we’ve seen Trump do with hydroxychloroquine and other things should take precedence over good science. 

So, this article is going to lay out how, in a world without a pandemic, the coronavirus vaccine development process should proceed while ignoring how the politically-driven FDA may subvert the process

Although I am very uncomfortable with the coronavirus vaccine development process over the past few months, it looks like, for better or worse, we’ll probably have one or two different vaccines in unknown quantities by early 2021. 

Of course, much of the optimism comes from experts like Dr. Anthony Fauci, one of the few rational public health experts who are willing to speak up in Washington DC. Maybe he has seen some secret data only available only to him and Bill Gates that supports this optimism. Maybe he just is trying to be the national cheerleader for healthcare.

I don’t know the real answer, but a lot of vaccine experts who have spent their lifetime studying vaccines, like Dr. Peter Hotez, MD Ph.D., who has expressed dismay at how politics may “trump” good science.

So, this article will try to lay out the development process, along with the independent controls that make sure that all vaccines are safe and effective.
Continue reading “Vaccine development process in the world of a coronavirus pandemic”

Coronavirus vaccine warp speed – Scotty screaming at Captain Bonespurs

coronavirus vaccine warp speed

The coronavirus vaccine warp speed project from old Bonespurs, aka President Trump, is causing Scotty to yell, “Aye, the haggis is in the fire now for sure.” Operation Warp Speed is moving ahead at full power with not a single Starfleet Officer of note on board.

Not on board with the Star Trek metaphors?

Well, the coronavirus vaccine warp speed operation is President Bonespurs’, I mean Trump’s, new task force that will bring us a new vaccine in a matter of months. That’s not going to happen in any case, especially when the President Bonespurs, OK, Trump, didn’t add any of the country’s top vaccine researchers to the task force. 

Instead, he opted for industry hacks who have made some curious choices on the top vaccine candidates to support. Let’s take a look at the coronavirus vaccine warp speed directive. Continue reading “Coronavirus vaccine warp speed – Scotty screaming at Captain Bonespurs”

Coronavirus vaccines – massive list of vaccine candidates for COVID-19

coronavirus vaccines

Because of the ongoing COVID-19 pandemic, the interest in coronavirus vaccines has been quite high (to say the least). I have been keeping an updated list of vaccine candidates in another article, but it was becoming so cumbersome to update, and I wanted to make information clearer to read, I decided to completely rewrite it.

This article about coronavirus vaccines will also be regularly updated, so stay tuned. Continue reading “Coronavirus vaccines – massive list of vaccine candidates for COVID-19”

COVID-19 vaccine research for coronavirus – updated 26 March 2020

COVID-19 vaccine

This article about COVID-19 vaccine research has been completely updated and can be found here. The comments section for this article has been closed.

Because the development of a potential COVID-19 vaccine is of massive interest currently, and because I have a passion for vaccine research and development, this article will a guide for vaccines involved with the coronavirus. It will be updated regularly, and I will post to social media when it is updated.

Right now, there are several COVID-19 vaccine candidates being developed by large and small pharmaceutical companies. Of course, social media will make it sound like they are all just around the corner, and they will all work.

It doesn’t work that way, so let me keep you updated with this guide to COVID-19 vaccine research and development. Continue reading “COVID-19 vaccine research for coronavirus – updated 26 March 2020”

Improving Vaccine Policy Making: A Dose of Reality – Dorit R Reiss and Paul A Offit

vaccine policy

This post is a preprint of an article to be published in Vaccine entitled “Improving Vaccine Policy Making: A Dose of Reality.” The authors are Dorit Rubinstein Reiss, Ph.D., Professor of Law at the University of California Hastings College of the Law (San Francisco, CA), and Paul A. Offit, MD, Professor of Pediatrics, Division of Infectious Disease, The Children’s Hospital of Philadelphia, The Perelman School at the University of Pennsylvania.

This article’s full citation is:

Reiss DR, Offit PA. Improving Vaccine Policy Making: A Dose of Reality. Vaccine. 2020 February 5. doi: 10.1016/j.vaccine.2020.01.036.

This preprint (see Note 1) is being published here, with permission from Professors Reiss and Offit, as a public service because it is an important part of the discussion on vaccine policy. Continue reading “Improving Vaccine Policy Making: A Dose of Reality – Dorit R Reiss and Paul A Offit”

Tetyana Obukhanych – another anti-vaccine appeal to false authority

TETYANA OBUKHANYCH

The old Skeptical Raptor took a bit of a break to recharge their batteries to tackle all of the pseudoscience that will be coming out in 2020. In lieu of new content, I will be republishing the top 10 most read articles on this blog during 2019. Here’s number 1 – the queen of the false authority of the anti-vaxxers – Tetyana Obukhanych. 

One of their favorite pseudoscientists of the anti-vaccine religion is Tetyana Obukhanych, someone who appears to have great credentials. Unfortunately, once you dig below the surface of her claims, there is no credible evidence in support. 

One of the most irritating problems I have with the anti-vaccine movement is their over-reliance on false authorities – they overrate publications (often in worthless predatory journals) or commentary from someone who appears to have all of the credentials to be a part of the discussion on vaccines, but really isn’t close to being a real vaccine scientist.

Nevertheless, credentials don’t matter – an “authority” on vaccines must follow the evidence that vaccines are safe and effective unless those “authorities” can provide robust, peer-reviewed, published evidence that vaccines aren’t. Someone like Tetyana Obukhanych almost never does.

For example, Christopher Shaw and Lucija Tomljenovic, two researchers in the Department of Ophthalmology at the University of British Columbia, have, for all intents and purposes, sterling credentials in medicine and science. However, they publish nonsense research (usually filled with the weakest of epidemiology trying to show a population-level correlation between vaccines and adverse events) in low ranked scientific journals.

Following in the footsteps of Shaw, Tomljenovic, James Lyons-Weiler, and Christopher Exley, let’s take a look at the background and education of the anti-vaccine hero, Tetyana Obukhanych. Continue reading “Tetyana Obukhanych – another anti-vaccine appeal to false authority”

Big Pharma vaccine profits – let’s take a closer look at this trope

vaccine profits

The old Skeptical Raptor is taking a bit of a break over the next few days to recharge his batteries for all of the pseudoscience that will be coming out in 2020. In lieu of new content, I will be republishing the top 10 most read articles on this blog during 2019. Here’s number 9 – the Big Pharma vaccine profits trope.

The old myth of the huge Big Pharma vaccine profits – it’s the subject of so many memes, tropes, and outright lies from the anti-vaccine religion. These vaccine deniers, who not only lack knowledge of science but also of basic corporate finance, believe that every Big Pharma CEO relies on vaccines for their next bonus check, which they use to buy their new Ferrari to show off to imaginary vaccine-injured children.

I am not naive – public corporations have an obligation to their shareholders and employees to maximize profits. That’s capitalism, I suppose.

But where this trope goes off the rails is when you realize that vaccine profits would be eclipsed by medical industry profits if Big Pharma simply stopped producing vaccines. It’s ironic that the anti-vaxxers claim that Big Pharma’s greed gives us vaccines, but if they were truly greedy they’d be out of the vaccine business.

This article is not going to be as much science as I usually do (just read the recent article on natural immunity) – it’s going to focus on finance and accounting. Yes, I’m finance and accounting geek as much as I am a science aficionado. 

Continue reading “Big Pharma vaccine profits – let’s take a closer look at this trope”

Anti vaccine conspiracies – the Skeptical Raptor is Paul Offit delusion

anti-vaccine conspiracies

Here we go with another set of anti-vaccine conspiracies from crackpots running a vaccine denier website. Once again, the old feathered dinosaur (modern or Cretaceous) is part of a broad conspiracy that includes Paul Offit, Dorit Rubinstein Reiss, UC Hastings College of Law, and Kaiser Permanente. Because anti-vaccine conspiracies are only more hilarious when they get more complicated.

Because I am amused by all of this, I must, according to the rule of scientific skepticism, snarkily debunk it. Now, science isn’t good at “proving the negative,” like trying to “prove” that I am not, nor have ever been, Paul Offit. On the other hand, I cannot prove that I am not Barack Obama. Or Tom Brady. Or Elvis. You just never know. Continue reading “Anti vaccine conspiracies – the Skeptical Raptor is Paul Offit delusion”

Postponement of a vaccine forum – anti-vaxxers hate science-based facts

vaccine forum

One of the things that the anti-vaccine zealots hate is a science-based vaccine forum. They cannot tolerate accurate and unbiased information being disseminated about the settled science of vaccine safety and effectiveness. Rather than have accurate facts being presented to parents, they would much rather do their best to suppress this information to make their cult of lies seem more impressive.

On 15 August 2019, Loma Linda University Humanities Program, part of the school’s College of Religion, was going to host a program, The Vaccine Mandate – Faith, Liberty, and the Pursuit of the Common Good. The two participants were Professor Dorit Rubinstein Reiss, Professor of Law at the University of California Hastings College of the Law, who is a frequent contributor to this and many other blogs, and Assistant Professor Wonha Kim, MD, who is the Director, Institute for Health Policy and Leadership at Loma Linda.

vaccine forum

As the title of the program suggests, this vaccine forum was to be a discussion of vaccine mandates, exemptions, and related issues. I had planned to drive from my home to attend the lecture since I thought it would be both interesting and enlightening. 

Unfortunately, for safety issues, mostly in the form of “protests” from the science-denying anti-vaxxers, Loma Linda University decided to postpone this important forum until a later date. With the mass murders of people in El Paso and Dayton, at roughly the same time, I’m sure that the university was worried about the somewhat violent tendencies of the anti-vaccine nutjobs played a significant role in the decision process.

I was genuinely worried about violence from the anti-vaxxers towards Professors Reiss and Kim. And against those in the audience who are strongly pro-vaccine, myself included. Although California does have strong anti-gun laws, that doesn’t mean some crackpot from another state could carry a weapon here to do harm to those of us who speak about science. We live amongst some awful human beings who place little value on human life – why else would they want little children to be a risk of horrible vaccine-preventable diseases. 

Larry Cook, whose anti-vaccine Facebook page was removed, threatens people with guns. Because that’s all that the anti-vaxxers have going for them, hate and violence.

There are literally dozens of Facebook posts from anti-vaxxers who have threatened harm towards Professor Reiss, Dr. Paul Offit, Dr. David Gorski, and many others that have put themselves at the forefront of supporting the science behind vaccine facts. These anti-vaxxers, who have nothing but fear, uncertainty, and doubt to support their pseudoscience need to resort to violent metaphors and hatred, just to make sure others support their cult of bovine fecal material.

If they had real scientific evidence supporting their claims, they would, of course, engage in civil discourse. Well, if they were actually capable of understanding those words.

An open vaccine forum, like this one at Loma Linda University, would have provided important information to parents so that they understand why mandatory (not really mandatory) vaccinations are critical to the well-being of not only their own children but all of the children in their communities. Sadly, the anti-vaccine religion cannot abide by accurate information, because it negates their lies.

Typical anti-vaccine protest – no science, no logic, no civility.

I am hoping that Loma Linda decides to bring back Professors Reiss and Kim to lead this vaccine forum in a safe manner sometime soon. And I will, once again, ride by horseback from my isolated cabin, where I observe Sasquatch, to attend the discussion. Because I like fact-based information, as opposed to the anti-vaccine, pseudoscience-loving, hate-filled, pro-disease, bogans that make up the anti-vaccine mob.

Vaccines save lives. Period. End of story. 

Dr. Robert Sears vaccine info misleads parents about measles

robert sears vaccine

Dr. Robert Sears vaccine info is false and misleading. On January 16, 2015, Sears, who refers to himself as Dr. Bob, is a California pediatrician and author of a controversial book on vaccines (critiqued here, pdf, or here by the fine folks at Science-Based Medicine).

He wrote in his Dr. Bob’s Daily and published on his Facebook page that measles is only rarely fatal in developed countries and that serious complications are rare. (In the likely event that Dr. Sears decides to delete his misleading comments, it’s archived here permanently.) 

And they were irresponsible. In a way that can put people – including children, including his patients – at serious risk. This is not the first time Dr. Bob Sears has made inaccurate claims about a vaccine-preventable disease, but on the background of the current measles outbreaks, the risk from his behavior is more imminent and more obvious. It is appropriate to react. Continue reading “Dr. Robert Sears vaccine info misleads parents about measles”