Severe COVID-19 and Alzheimer’s disease risk may share a genetic link

COVID-19 Alzheimer's disease

The risk for Alzheimer’s disease (AD) and for severe COVID-19 appear to share a common genetic mechanism that is involved with the immune response to viruses. This does not mean that COVID-19 increases the risk for Alzheimer’s disease, only that there appears to be a single genetic variant that increases the risk for both.

Researchers found that one genetic variant in the oligoadenylate synthetase 1 (OAS1) gene increases both the risk for AD of severe COVID-19 outcomes.

Risk for Alzheimer’s disease and susceptibility to severe COVID-19 share a common genetic mechanism involved in the immune response to viruses, according to a peer-reviewed article just published. The findings could lead to new treatment targets to slow the progression and severity of both diseases. If these findings bear out, it could suggest new drugs that could treat both diseases.

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