Vaccine safety – a huge systematic review says they don’t cause autism

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Not that most of us need to be convinced, but there’s another huge systematic review that examined vaccine safety. Unsurprisingly, it shows that there are no major safety signals post-vaccination, plus no vaccine is linked to autism.

It’s ironic that this study is a high-quality systematic review and meta-analysis, the top of the hierarchy of biomedical research, while anti-vaxxers rely upon retracted articles published in predatory journals.

So, I want to do a quick review of this new article so that we can continue to support the settled science of vaccine safety.

Vaccine safety systematic review and meta-analysis

A systematic review and meta-analysis of vaccine safety published in Vaccine, by Courtney Gidengil  et al., examined 338 vaccine safety studies that met the inclusion criteria. The studies included millions of subject.

Here are the most important results:

  • The strength of evidence (SoE) was high for no increased risk of autism following the measles, mumps, and rubella (MMR) vaccine.
  • There was high SoE for increased risk of febrile seizures after the MMR vaccine. However, even though febrile seizures may be frightening to the parent, they usually only last a few minutes and do not cause any long-term complications.
  • There moderate SoE for no increased risk of intussusception with rotavirus vaccine at the latest follow-up.
  • There was high SoE that there was no increased risk of diabetes.
  • There was no evidence of increased risk or insufficient evidence for key adverse events for newer vaccines such as 9-valent human papillomavirus and meningococcal B vaccines.
  • For adults, there was no evidence of increased risk or insufficient evidence for key adverse events for the new adjuvanted inactivated influenza vaccine and recombinant adjuvanted shingles vaccine.
  • There was no evidence of increased risk for key adverse events among pregnant women following tetanus, diphtheria, and acellular pertussis vaccine, including stillbirth (moderate SoE).
Photo by Mat Napo on Unsplash


I’m not sure what else to say. This huge systematic review and meta-analysis tells us that vaccines are incredibly safe.

There is no evidence that they cause autism, diabetes, and other adverse events that many attempt to link to vaccines.

Vaccines are demonstrably safe using the best science out there. That’s settled science.


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The Original Skeptical Raptor
Chief Executive Officer at SkepticalRaptor
Lifetime lover of science, especially biomedical research. Spent years in academics, business development, research, and traveling the world shilling for Big Pharma. I love sports, mostly college basketball and football, hockey, and baseball. I enjoy great food and intelligent conversation. And a delicious morning coffee!