Ginkgo biloba is actually an interesting plant because it has been relatively unchanged for nearly 270 million years. It is considered a living fossil, an informal term used for species like G. biloba that appear to be the same as a species otherwise only known from fossils and which has no close living relatives. The genus Ginkgo was fairly widely distributed until about 100 million years ago. It slowly disappeared from the fossil record until it was found only in one small part of China about 5 million years ago, where it is found today.
The tree is native to China and is known to have been widely cultivated early in human history. It is used as a food source by various Asian cultures, with the Chinese eating the meaty gametophytes and the Japanese the whole seed. Unfortunately, the seed also contains a chemical, 4′-O-methylpyridoxine, that can be poisonous if consumed in a sufficiently large enough quantity. Continue reading “Ginkgo biloba and the brain–myth vs. science”
In general, if a pharmaceutical company makes any changes to the ingredients, even something as simple as a binder in the pill, it must re-file with the regulatory authorities for clearance to do so. Even if a manufacturer changes equipment or a process, without changing the the ingredients, it is required to file those changes with the FDA, and they may not proceed with the change.
Pat Summitt, probably one of the greatest basketball coaches ever, has stepped down as the coach of the University of Tennessee’s women’s basketball team. She announced that she had early-onset Alzheimer’s disease (AD) in August 2011, and she had coached the 2011-12 season, but today, as a result of the disease, she resigned. During her career, she won 8 NCAA Division 1 Women’s Basketball Championships, a record that is almost impossible to comprehend. Her reputation and success is the envy of college sports.
Early onset AD is usually defined as a diagnosis before the age of 65. Early onset AD may occur in individuals as young as their 30’s (very rare), but with most diagnoses in patients in their 50’s. Summitt was diagnosed at the age of 58 (and without knowing everything, she might have had symptoms earlier), so the age of onset is not unusual. Continue reading “Early onset Alzheimer’s disease ends coaching career of Pat Summitt”