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Evidence supports rotavirus vaccine effectiveness – vaccines save lives

The CDC recently published robust evidence that supports rotavirus vaccine effectiveness. There is nothing more powerful than epidemiological studies that show a correlation (and causality) between the drop in the incidence of a vaccine preventable disease immediately after wide introduction of a the vaccine itself in a relatively closed population.

Read More »Evidence supports rotavirus vaccine effectiveness – vaccines save lives

Worldwide vaccine uptake-2014


I make it a point to update this blog with the most current CDC analysis of vaccine uptake in the USA for kindergarten children (usually around 5 years old). Generally, the numbers have stayed stable, at around 95% vaccinated, although there is high variance from state to state, and locality to locality. The weakness in the vaccination uptake in the USA is that some areas may approach 100% vaccinated, but then other areas may be 50%, which makes those areas with low vaccine uptake susceptible to a quick spread of diseases that are not endemic to the USA (such as measles, polio, and others) through that unvaccinated population.

Given the 95% vaccine uptake rate, it begs the questions of why I push so hard for vaccination–because I want to protect the lives of children, and those 5% who aren’t vaccinated are at risk of serious disease and even death. And vaccines are the safest way to protect a child–protect them from death.

Nearly 55% of the readers of this blog are not American (a couple of years ago,this blog got a regular reader from Iran, which meant that all countries were represented amongst this blog’s readers). I have been accused of being a bit American-centric, but at the same time, I was also curious about vaccine uptake worldwide. Read More »Worldwide vaccine uptake-2014

Why we immunize–protect children from hospitalization for diarrhea


Update 1. Added more information about the power of the herd immunity written by Tara Haelle.

One of the most recent and important vaccines added to the current schedule of immunization is the rotavirus vaccine, introduced in the USA in 2007. Before the introduction of the vaccine, rotavirus was the most common cause of severe gastroenteritis in US children under 5 years old. Each year, rotavirus caused an estimated 20 to 60 deaths, 55,000 to 70,000 hospitalizations, and nearly half a million non-emergency visits to healthcare facilities.

A study, recently published the Pediatrics journal, concluded that, after the rotavirus vaccines was introduced, the numbers of diarrhea-related illness in US children dropped significantly. Moreover, probably as a result of herd immunity (where transmission through a population is inhibited by individual who are immune to the disease), the study found that the rate of hospitalizations related to the virus dropped substantially in both vaccinated and unvaccinated children.

The research examined health insurance data from across the USA (except for Medicaid, and a few states that don’t report data) for children under 5 years, cross tabulating various gastrointestinal illnesses with hospitalizations and other medical care. It also compared the same information to the vaccination status of those children. Finally, they gathered data about these illnesses from 2001 through 2006 (before the vaccine was introduced) and 2007-11, to compare hospitalization and other medical facility encounters between the pre- and post-vaccine groups.Read More »Why we immunize–protect children from hospitalization for diarrhea

Physicians get rich from vaccinating children–refuting another myth

vaccines-moneyOne of myths promulgated by the antivaccination cult (and there are so many of these myths) is that through some mysterious financial system, physicians make boatloads of money from vaccinating kids. Like almost all of the myths pushed by these vaccine denier, it does not even have a kernel of truth. In fact, in this case, I’m not even sure it’s in the same planetary system as the truth.

In an article by O’Leary et al., published recently in Pediatrics, we see that there is no evidence that vaccines are a major profit center for primary care physicians (which are usually pediatricians in the case of children). In fact, the article seems to indicate that vaccinations are a financial burden for many pediatricians.

The cost of vaccinating each child from birth to age 18 is around $2500, depending on the vaccines used. Multiply this by the 100’s of patients each practice may manage, and you’re looking at several million dollars in vaccines, all of which has to be purchased by the private physician, then given at cost or even below cost, depending on reimbursement, to patients.Read More »Physicians get rich from vaccinating children–refuting another myth

Reports of vaccine related effects can be useful


©, 2007. Photographer's son actually receiving RotaTeq vaccine and giving a smile to Paul Offit for keeping him from ever getting a rotavirus infection.

©, 2007. Photographer’s son actually receiving RotaTeq vaccine and giving a smile to Paul Offit for keeping him from ever getting a rotavirus infection.

Vaccine deniers, especially in the USA, use the passive data from the Vaccine Adverse Event Reporting System (VAERS), a system where individuals can report supposed adverse events post-vaccination, to “prove” certain adverse events. The data is considered to be “passive” because the individual reports can be made online, by fax or by mail–real causal events may be underreported and hyped, imaginary issues with no causality, can be over-reported. However, without medical investigations of causality between the vaccination and the claimed adverse events that are reported to the VAERS database, the data have no real value.

Frankly, VAERS can be gamed by those with nefarious intentions. In reality, VAERS is a feel-good system for those who think that there’s a link between vaccines and something terrible, but without an active investigation, the data is just above the level of being totally meaningless. Most epidemiologists know it is valueless. Even the VAERS system itself says that the data cannot be used to ascertain the difference between coincidence and true causality.

Furthermore, there is a background rate for mortality (death) or morbidity (abnormal medical condition), across all causes, irrespective of whether an individual is vaccinated or not, and unless you understand the background rate, the vaccine “mortality” rate has no scientific meaning. In fact, we could provide data that shows anything might cause any adverse medical event, like playing video games leads to prostate cancer, but we would have no evidence of any type of causality whatsoever.Read More »Reports of vaccine related effects can be useful

Why we vaccinate–protect kids from rotavirus induced seizures


H. Fred Clark and Paul Offit, the inventors of RotaTeq, a pentavalent rotavirus vaccine.

H. Fred Clark and Paul Offit, the inventors of RotaTeq, a pentavalent rotavirus vaccine.

Rotavirus is a virus that causes gastroenteritis, an inflammation of the stomach and intestines. Rotavirus causes severe watery diarrhea, often with vomiting, fever, and abdominal pain. In babies and young children, it can lead to dehydration (loss of body fluids). Globally, it causes more than a half a million deaths each year in children younger than 5 years of age. 

Prior to the launch of the rotavirus vaccine (RotaTeq® or Rotarix®) in the United States in 2006, rotavirus was the leading cause of severe diarrhea in infants and young children. Before the vaccine became available, almost all children in the United States were infected with rotavirus before their 5th birthday. Each year, in the US, rotavirus lead to more than 400,000 doctor visits; more than 200,000 emergency room visits; 55,000 to 70,000 hospitalizations; and 20 to 60 deaths in children younger than 5 years of age. After the introduction and widespread use of the vaccine, a Cochrane systematic review concluded that the rotavirus vaccines may prevent up to 96% of severe diarrhea cases arising from rotavirus.Read More »Why we vaccinate–protect kids from rotavirus induced seizures

Vaccination coverage in US children,19-35 months–uptake still high

The United States Centers for Disease Control and Prevention (CDC) has reported in the 2012 National Immunization Survey (NIS) that the majority of children, age 19-35 months, remained extremely high from 2008 through 2012, although there was a small, but statistically significant drop in uptake of some vaccines from 2011 to 2012. In addition, the CDC specified a substantial concern about clusters of unvaccinated children in widespread communities that are at risk from vaccine preventable diseases, and may pose a health risk to the community at large.

The study results were based upon a survey (cell and land-line phone calls with follow-up details from the health care provider) of about 16,000 children (an extremely large sampling for a survey). The data was then adjusted for racial/ethnic, income, and other population factors. Even though the CDC provided data from 2008-2012, the current method of polling was started in 2011, and only results from 2011 and 2012 are mathematically comparable.




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Vaccines do save lives, and science can demonstrate it

If you spend any time reading the antivaccination rants, you will hear about all kinds of conspiracy theories, pseudoscience, and scaremongering. Given that there is little scientific evidence that supports their beliefs, they have little choice but invent strawman arguments to make their point. One of the more amusing strategies of antivaccine cult is to claim that diseases were going away before vaccinations. These people believe, without any evidence whatsoever, that diseases like polio, measles, and chickenpox were disappearing because of better sanitation. Or better nutrition. Or something other than what really ended these diseases–vaccines. It’s a historical revisionism of a legendary level.

Admittedly, part of this belief is that people lack the cultural memory of some of these diseases. Few parents born after 1970 would remember classmates who had been stricken with polio. Few would have remember measles, mumps, or other epidemics sweeping through a school. They just don’t remember it, because vaccines introduced in the 50’s and 60’s reduced, and in the case of smallpox, eliminated the disease. Of course, there is evidence that support the theory that vaccines end diseases. But we don’t have to go back 40 or 50 years to show this happens, but we can talk about a disease that has been drastically reduced in the last few years, just because of a new vaccine.

Read More »Vaccines do save lives, and science can demonstrate it

Debunking the “vaccines aren’t tested” myth

There are so many silly memes that have arisen from the anti-vaxxers, all of which have been thoroughly debunked. Everything from the well-worn (and worn-out) “vaccines cause autism” fable, quashed here, to the “these diseases aren’t dangerous”, which, of course, couldn’t be farther from the truth. One of the more annoying of the tales pushed by the vaccine denialists is that vaccines aren’t tested thoroughly before being used on unsuspecting infants. I do not know where this started, or why it started, but like much in the anti-vaccination world, it really doesn’t matter. It just passes from one person to another across google, and individuals with no research background hold this particular belief as if it were the Truth™.Read More »Debunking the “vaccines aren’t tested” myth