The breadth and depth of vaccine research

I have frequently stated that the breadth and depth of vaccine research, which provides solid evidence on the safety and effectiveness of vaccines, overwhelms the misinformation, logical fallacies, and conspiracies pushed by the Society for Promotion of Vaccine Preventable Diseases (that is, the antivaccine cult).

In other words, there is so much evidence, published in generally respected, high quality journals, that it is the basis of a pure, 24-karat gold scientific consensus about vaccine safety and effectiveness. Using just one search parameter, vaccines + efficacy + safety, there are over 4200 articles published over the past 55 years on vaccines. Other search parameters show even more results.

As I’ve said time and again, the only thing that matters to science is the quality and quantity of repeated evidence derived from a broad range of different studies. We’ve got that.

For a research project recently, I was looking into innovative treatments for multiple sclerosis (MS), a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. This damage disrupts the ability of parts of the nervous system to communicate, which results in numerous symptoms, including physical, mental and psychiatric problems. MS is probably an autoimmune disease caused by an infection, although a definitive cause has not been identified at this time.

In my research, I was reviewing research in new, innovative treatments, and ran across studies of a new drug called teriflunomide (trade name Aubagio, marketed by Sanofi, a large French pharmaceutical company), which recently received EU and FDA approval. The drug may have some benefits over current therapies in treating MS, but that’s not the point of this article.

When reviewing the research on terifluonomide, I ran across an interesting vaccine article published in a high quality journal, Neurology, by a group of French medical researchers, including a physician named Myriam Benamor, MD. As I mentioned in my other articles about how to research a topic, if I’m unfamiliar with a research topic, I tend to look at the author’s qualifications and background.

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Dr. Benamor has a long history of research in various areas of medicine, with a lot of experience in new research in neurology. That’s impressive to me.

The vaccine and terifluonomide article was interesting, not because of the new MS drug (although for MS patients, it’s very interesting), but because the effectiveness of the flu vaccine was examined with use of this drug. This isn’t an article about the flu vaccine itself, but about how a new drug impacts effectiveness of the vaccine.

[infobox icon=”quote-left”]This study provides evidence that teriflunomide generally does not adversely impact the ability of patients with RMS (relapsing multiple sclerosis) to mount immune responses to influenza vaccination..[/infobox]

Here’s evidence of the safety and effectiveness of the flu vaccine by examining how an important new drug may interact with flu vaccine. This is important information because someone with MS should be protected against vaccine preventable diseases, but more than that, most MS treatments may have an impact on the immune system. The results of this study support the effectiveness of this vaccine with this MS treatment.

The research team also looked at another vaccine, in this case,  rabies, to examine the same issue – effectiveness of the vaccine with terifluonomide. Same results, the vaccine works.

When I speak of the breadth and depth of vaccine research, I mean it literally. If the vaccine deniers want to refute every piece of evidence that’s ever been done on vaccines, well, they better find a group of neurologists to contradict this piece of the scientific consensus on vaccines.

Just one more point. The research used a Sanofi drug, Aubagio, along with Sanofi vaccines. Yes, you might invent some appeal to conspiracy, but that doesn’t constitute evidence. Get your MD and PhD in neurosciences and neurology, do the research, refute the high quality research here.

Setting aside the entirely predictable logical fallacies that will flow from the keyboards of the vaccine deniers, this research just forms a tiny portion of evidence that overwhelmingly supports the safety and effectiveness of vaccines. The research and evidence is so broad and so deep, that the only thing left for the anti-vaccination cult are lies, misinformation and logical fallacies.

I have found literally hundreds of other studies, similar to these, that support the effectiveness and safety of vaccines in unique medical situations. Refute that, vaccine deniers.

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The Original Skeptical Raptor
Chief Executive Officer at SkepticalRaptor
Lifetime lover of science, especially biomedical research. Spent years in academics, business development, research, and traveling the world shilling for Big Pharma. I love sports, mostly college basketball and football, hockey, and baseball. I enjoy great food and intelligent conversation. And a delicious morning coffee!

62 Replies to “The breadth and depth of vaccine research”

  1. Treating MS as a disease is the problem, there are many people who have taken unfermented wheat and also dairy out of the diet, started eating non processed foods and recovered.

  2. When I was in high school, there was a gold standard consensus on Global Cooling or something like that. Well, it was a while back, but…Science, in time, will show itself in error with very few exceptions. What we truly know is so minuscule when compared to what we have to learn.

    Of course there will be vaccine safety studies…total vaccine + safety is like 13,000. Vaccines have saved millions of lives. I have my personal vendetta,however, and I didn’t get it off of any antivax website. I tend to think for myself, I am a housewife.

    What concerns me is how little long term study has been done on kids who have had severe reactions. Like kids with Dravet Syndrome. They seem to be immunocompromised somehow, maybe, IDK.

    I want you to see something below. A ~lawyer~ considered what I had to say, even though no scientist ever has. A knee jerk reaction, when you say “vaccines”…is always…studies prove it is not related to autism. But it is, just not in the way you might think. Twenty five percent of kids with Dravet have autism. Out of 4,000,000 births every year, about .00003% will have Dravet (1 in 30,000). Yet, Dravet kids make up 2.5% of the total of kids having febrile seizures in serious reactions to vaccines. That means Dravet makes you 750fold more likely to have a febrile seizure when you are vaccinated. Dravet causes autism, it also by order of magnitude increases the chance of severe vaccine reactions. I would hesitate to say, any child who had a febrile seizure to vaccines should be watched for signs of epilepsy, because ~something~ is making the other 97.5% of kids seize…and it may be another innate susceptibility.

    I went on Orac’s site…and was kindly given a study in which a long term follow up was done on kids who had an HHE to the DTwP, my son’s reaction that I probably have obsessed too much on. Fifty percent of the kids had genetically inherited neurological disease. You understand, they were BORN with the anomaly. Things like possible TSC or NF, Goldenhar Syndrome, Familial Language Disorder…something else. BUT…a genetic difference led to a vastly over-represented group among those having a severe reaction. This was the only long term follow up of reactions to DTwP I am aware of. Once again, a genetic susceptibility to vaccine reaction.

    If I put vaccine + severe + reaction + follow + up, I come up with about 45 studies. One on the first page actually seemed to address my particular query. The lack of curiosity among brain doctors, I understand. No one wants to lose their job or prestige from being on the wrong side of science at the time. Still….we know so little about autism/Dravets/Epilepsy….is this a rock we don’t want to look under for politics sake? It wouldn’t take that much to actually follow up on kids on VAERS.

    I hope Dorit forgives me one day. But then again, maybe some parents who think the vaccines caused their childrens autism will understand what I am trying to say, and vaccinate their children, when they otherwise may have not. That, also, is a highly political decision on their part. It is wonderful to have someone to blame for a child who is going to have a more difficult life than many.

    I don’t expect you to listen, or for anything to change. Still, I have been looking to science for an answer to the HHE besides, it’s not the vaccine, because that is silly and illogical. That’s not even the question.The question is, what makes some children, and according to parent concerns, especially autistic or otherwise neurologically compromised children more susceptible to vaccine reactions? See, everybody wins…science learns more about neurological differences, and parents are heard when they tell their stories.

        1. Funny thing about VAERS: I can log on there right now, and after putting in my info, including what vaccine I got, and say that MMR (for example) allows me to fly, and it would stay.

    1. Your misinformation here is legendary. First of all, there was never consensus that there was global cooling.

      Please show any level of plausibility that immune systems can be harmed long term? Any? Didn’t think so.

      Your search was bullshit. You didn’t actually read the articles, most of which showed the opposite of what YOU think.

      Go away. You have nothing to present here.

      1. You are quite unkind. The science will show I am correct one day, it is just logical.

        You don’t even understand what I am saying, or your second sentence would make sense. Just another knee-jerk diatribe against parents of kids who had a reaction to vaccines. You are blinded, not by science, but by the need to be seen as totally intolerant towards anyone who doesn’t agree with you. That’s a sign of insecurity. Any weakness would just encourage a guppy like me.

      2. “I have frequently stated that the breadth and depth of vaccine research,
        which provides solid evidence on the safety and effectiveness of
        vaccines” vaccine meme

        Again we see often repeated junk science statements pretending to be facts. We also see the ad hom attack on someone trying to ask relevant questions.

        This is medical science in action – quasi religious woo science and avoidance of debate.

          1. Well medical science likes to think it is. You equate publication bias with facts and ad hom with critique. I am not done pointing out your breath smells. We will never go away – ever

            1. Not accepting bullshit, isn’t trolling – unless you are a septic believer

      3. .The question is, what makes some children, and according to parent
        concerns, especially autistic or otherwise neurologically compromised
        children more susceptible to vaccine reactions? That is all. I had to change my name as can’t log into Disqus. Rosabw

        1. They’re not. The ASD is series of genetic mutations that present around the ages when certain vaccines are scheduled to be given. Due to most folks sleeping through science class, or just not understanding correlation and causation, plus misinformation online and from sometimes well-intentioned yet ignorant friends who’ve been taken in by con artists, they think the condition they passed on to their kids is something they got from vaccines.

          1. Rev:
            Dravet’s Syndrome is inherited. You are “conceived” with it. But, 27% of kids with Dravet have a Febrile Seizure with vaccination. The odds of that happening are .05 to 6 per 100,000 typically. If you are predisposed because of Dravet, the odds are 1 in 4 you will have a reaction. I think thousands of parents could be relieved to find that their child was predisposed to vaccine reaction, and not that the reaction caused Autism. It’s not just Dravets. A child genetically predisposed to epilepsy in any form is more likely (3x’s) to react to a vaccine. My son is adopted, but Tuberous Sclerosis was brought up because of birth marks that develop at the same time as the fetus’s CNS, and indicate a possible genetic disease. (We can’t afford $3000 testing). A child with Tuberous Sclerosis is more likely to react to a vaccine. In fact, it is sometimes an indicator to look for neurological involvement, the vaccine ~reaction~, as it should be. Parents would know much more about their children’s autism if we looked to serious vaccine reactions as being indicators of rare disease. Denying that some children are more prone to reaction isn’t science. To me, that’s what it seems you are saying, but maybe I’ve misunderstood.

            Can you understand…i am NOT saying the reaction caused a disease that was probably determined at conception?

            1. Re-read my comment. Do it as many times as it takes for the words to become clear.

            2. Why did you feel the need to repeat what I’d said originally?

    2. Please join us at our next Logical Fallacy Fun Run. Participants start at a faulty premise and then run as far as they can. The racer who runs the farthest loses. All participants get a T-shirt.

  3. Thank you for opening this new discussion of new research on MS and immunity. I am sure the nut burgers will be all over it.

      1. Maybe if they actually read their own studies and realised the flaws in vaccine mythology they might stop wasting so much time.

            1. Both the short and long answer to that question is “Yes”.

              Philip Hills of the Hope Osteopathic Clinic.

          1. Whatever your qualifications once were pasta, they have left you disabled and unable to string more than one expletive together. Must be that years of annual flu vaccine accumulating mercury effect. Nice cohort. Try not to think too hard, it might fall off……………

            1. When you make up shit, you really need to provide evidence of your qualifications. Pasta dude knows his science, so no one cares if he’s a janitor or a Nobel Prize winning scholar.

              You on the other hand…meh.

            2. “Trust me, I am not a doctor”

              Nor any other kind of medical professional.

            3. One thing I can state unequivocally is that my abilities to string together multiple expletives have only improved over the years. I really need to give the credit for that to morons like you and the rest of your ignorant cult. You’re the inspiration I need to continue to combine colorful descriptions to describe your stupidity. Thank you.

            4. accumulating mercury effect.

              No, no, no. Mercury is in retrograde! Saturn is ascending in the fifth house. Venus rising.

              Pffft. Amateur.

            5. Are you the doctor Foster that went to Gloucester in a shower of rain or the Shipman of the Foster report – that mass murdering doctor that 2 weeks before he was arrested, passed all his medical board CPD as an ‘exemplary practitioner?’

            6. I’m a little busy here! I’m trying to decide what to have for dinner. Go talk to HyperZombie, he’s got more brains than a brain pie…hmmmm…brain pie… perfect!! Care to donate???

            7. I once dug a pit and filled it with clouds….or was it clowns…. well whichever it was it began to smell…Ahah! must have been clowns. Clouds don’t smell, they taste of butter. And tears.

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