How vaccines have reduced diseases in one easy graphic

Information graphic on the results of vaccine use in the United States from Leon Farrant, 2013.
Information graphic on the results of vaccine use in the United States from Leon Farrant, 2013.

If there was any doubt about the success of vaccines this graphic shows it clearly. We can eliminate confounding variables such as improved sanitation, since many of these diseases (if not most) are not dependent upon the quality of sanitation, and are merely transmitted from individual to individual. We can eliminate the improvement in health care (other than the obvious one of the accessibility of vaccines) because improved health care wouldn’t prevent most of these diseases.

As a result of vaccines, we have eliminated polio, smallpox and diphtheria in the United States. Many other diseases, measles, mumpsrubella, tetanus, and  Haemophilus influenzae type b, are nearly eliminated. Though some people in the antivaccination world would make you believe that these diseases are not serious (the pox party is a perfect example of this belief), most of these diseases have known serious consequences for a statistically significant portion of those who get the disease. These adverse consequences may be as minor as hospitalization to as serious as life long chronic health issues or death.

In approximately one generation, modern medical science has radically changed the risks that children face to these diseases. For that, we parents should be grateful

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Key citations:

 

Repeated contact with mumps may overwhelm immunization

A recent study, published in The New England Journal of Medicine, concluded that after an intense face-to-face educational technique, used among Orthodox Jews, apparently led to an outbreak of mumps in 2009 and 2010, despite high vaccination rates in the group. In a one-year period, from June 28, 2009, through June 27, 2010, 3,502 cases of mumps were reported in New Jersey, New York City and New York’s Orange and Rockland counties. The study examined 1,648 of those cases, 97% were Orthodox Jews, and found 89% had received two doses of the vaccine and 8% received one dose, a relatively high rate of vaccination.

Many of the individuals attended a religious school where they practiced an intense training technique called chavruta, which involves close contact with a partner across a narrow table. Partners change frequently, and he discussion is often loud and may involve shouting since a larger group may be close to each other, all trying to make an argument or point. This prolonged contact overwhelmed the immunity, from the mumps vaccination (part of the MMR vaccine), for individuals. The study did find high rates of two-dose coverage reduced the severity of the disease and the transmission to people in settings of less exposure. Also, the study found that mumps did not spread outside of the Orthodox Jewish community in the area, further supporting the overall effectiveness of the mumps vaccine in the broader community. Continue reading “Repeated contact with mumps may overwhelm immunization”

The importance of Cochrane Reviews to science based medicine (updated)

Cochrane Collaboration Copyrighted from the Cochrane Collaboration

The Cochrane Collaboration is a critically important source in evidence-based medicine, and a useful tool in providing analytical evidence that can debunk pseudoscientific beliefs. Cochrane’s goal is to organize research data and publications in an logical way that helps physicians and researchers make appropriate decisions about a proposed new therapy, medication or clinical idea. Cochrane Reviews are:

…are systematic reviews of primary research in human health care and health policy, and are internationally recognised as the highest standard in evidence-based health care. They investigate the effects of interventions for prevention, treatment and rehabilitation. They also assess the accuracy of a diagnostic test for a given condition in a specific patient group and setting.

Each systematic review addresses a clearly formulated question; for example: Can antibiotics help in alleviating the symptoms of a sore throat? All the existing primary research on a topic that meets certain criteria is searched for and collated, and then assessed using stringent guidelines, to establish whether or not there is conclusive evidence about a specific treatment. The reviews are updated regularly, ensuring that treatment decisions can be based on the most up-to-date and reliable evidence. Continue reading “The importance of Cochrane Reviews to science based medicine (updated)”

Debunking the “vaccines aren’t tested” myth

There are so many silly memes that have arisen from the anti-vaxxers, all of which have been thoroughly debunked. Everything from the well-worn (and worn-out) “vaccines cause autism” fable, quashed here, to the “these diseases aren’t dangerous”, which, of course, couldn’t be farther from the truth. One of the more annoying of the tales pushed by the vaccine denialists is that vaccines aren’t tested thoroughly before being used on unsuspecting infants. I do not know where this started, or why it started, but like much in the anti-vaccination world, it really doesn’t matter. It just passes from one person to another across google, and individuals with no research background hold this particular belief as if it were the Truth™. Continue reading “Debunking the “vaccines aren’t tested” myth”

Maryland proposes new vaccine requirements for students

The Baltimore Sun is reporting that Maryland is proposing revised vaccination regulations that would require incoming kindergartners to receive a chicken pox booster vaccination (varicella vaccine). It is also requiring seventh graders to get a booster against tetanus, diphtheria and pertussis, (DTaP vaccine). In addition, Maryland also wants to include a vaccine against Meningococcus, a bacterium that causes meningitismeningococcemiasepticemia, and rarely carditisseptic arthritis, or pneumonia. The state also wants to increase the requirement for the number of MMR vaccinations for measles, mumps and rubella.

If the proposed changes go into effect, Maryland would be aligned with standards recommended by the Centers for Disease Control and Prevention’s National Advisory Committee on Immunization Practices. To this date, 36 states have adopted such standards. The new guidelines, if adopted, would to into effect in 2014.

According to David Bundy, an assistant professor of pediatrics and childhood adolescence at the Johns Hopkins Children’s Center,

The recommendations for these immunizations are not new nationally, this is just updating the state’s requirement to reflect the existing recommendations. It just makes us all look like we’re in alignment with what we’re doing, and it tightens the safety net at schools for kids who may be missing vaccines.

I’m sure the anti-vaccine crowd will be complaining soon.

via Maryland proposes additional pertussis, chicken pox booster requirement | Vaccine News Daily.

Measles outbreak in United Kingdom–worst since introduction of MMR vaccine

The United Kingdom’s Health Protection Agency (HPA) has announced that a measles outbreak in the Merseyside area is the largest since the MMR vaccine (vaccination for measles, mumps and rubella) was introduced in 1988. There have been 113 confirmed cases, and another 43 probable cases–28 of these individuals needed hospital treatment.  

About one-quarter of the confirmed cases were teenagers (15-18 years old) and young adults who were never vaccinated as children. Another quarter of the cases were in children under the age of 13 months who are too young to be vaccinated. The majority of the remaining confirmed cases were unvaccinated children over 13 months and less than 15 years old.   Continue reading “Measles outbreak in United Kingdom–worst since introduction of MMR vaccine”

The importance of Cochrane Reviews to evidence based medicine

Cochrane Collaboration Copyrighted from the Cochrane Collaboration

The Cochrane Collaboration is a critically important source in evidence-based medicine, and a useful tool in providing analytical evidence that can debunk pseudoscientific beliefs. Cochrane’s goal is to organize research data and publications in an logical way that helps physicians and researchers make appropriate decisions about a proposed new therapy, medication or clinical idea. Cochrane Reviews are:

…are systematic reviews of primary research in human health care and health policy, and are internationally recognised as the highest standard in evidence-based health care. They investigate the effects of interventions for prevention, treatment and rehabilitation. They also assess the accuracy of a diagnostic test for a given condition in a specific patient group and setting.

Each systematic review addresses a clearly formulated question; for example: Can antibiotics help in alleviating the symptoms of a sore throat? All the existing primary research on a topic that meets certain criteria is searched for and collated, and then assessed using stringent guidelines, to establish whether or not there is conclusive evidence about a specific treatment. The reviews are updated regularly, ensuring that treatment decisions can be based on the most up-to-date and reliable evidence. Continue reading “The importance of Cochrane Reviews to evidence based medicine”